Entity Details

Primary name IL12A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29459
EntryNameIL12A_HUMAN
FullNameInterleukin-12 subunit alpha
TaxID9606
Evidenceevidence at protein level
Length219
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesIL12A

GO terms

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GOName
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0005125 cytokine activity
GO:0005143 interleukin-12 receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0006955 immune response
GO:0008083 growth factor activity
GO:0009615 response to virus
GO:0010224 response to UV-B
GO:0016032 viral process
GO:0016477 cell migration
GO:0019221 cytokine-mediated signaling pathway
GO:0031906 late endosome lumen
GO:0032496 response to lipopolysaccharide
GO:0032700 negative regulation of interleukin-17 production
GO:0032729 positive regulation of interferon-gamma production
GO:0032816 positive regulation of natural killer cell activation
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0034393 positive regulation of smooth muscle cell apoptotic process
GO:0035722 interleukin-12-mediated signaling pathway
GO:0042163 interleukin-12 beta subunit binding
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043514 interleukin-12 complex
GO:0045513 interleukin-27 binding
GO:0045785 positive regulation of cell adhesion
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0046982 protein heterodimerization activity
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050709 negative regulation of protein secretion
GO:0050830 defense response to Gram-positive bacterium
GO:0051135 positive regulation of NK T cell activation
GO:0070757 interleukin-35-mediated signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0098586 cellular response to virus
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:2000510 positive regulation of dendritic cell chemotaxis

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR004281 Interleukin-12 alphaFamilyFamily
IPR009079 Four-helical cytokine-like, coreFamilyHomologous superfamily

Diseases

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