Entity Details

Primary name CALCR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30988
EntryNameCALCR_HUMAN
FullNameCalcitonin receptor
TaxID9606
Evidenceevidence at protein level
Length474
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesCALCR

GO terms

Show/Hide Table
GOName
GO:0001540 amyloid-beta binding
GO:0001635 calcitonin gene-related peptide receptor activity
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004948 calcitonin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008528 G protein-coupled peptide receptor activity
GO:0010628 positive regulation of gene expression
GO:0010739 positive regulation of protein kinase A signaling
GO:0010942 positive regulation of cell death
GO:0030424 axon
GO:0032841 calcitonin binding
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0038041 cross-receptor inhibition within G protein-coupled receptor heterodimer
GO:0045762 positive regulation of adenylate cyclase activity
GO:0051384 response to glucocorticoid
GO:0051897 positive regulation of protein kinase B signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0097643 amylin receptor activity
GO:0097647 amylin receptor signaling pathway
GO:0150056 amylin receptor complex 1
GO:0150057 amylin receptor complex 2
GO:0150058 amylin receptor complex 3
GO:1904645 response to amyloid-beta
GO:1905665 positive regulation of calcium ion import across plasma membrane

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000832 GPCR, family 2, secretin-likeFamilyFamily
IPR001688 GPCR, family 2, calcitonin receptorFamilyFamily
IPR001879 GPCR, family 2, extracellular hormone receptor domainDomainDomain
IPR003287 GPCR, family 2, calcitonin receptor familyFamilyFamily
IPR017981 GPCR, family 2-likeDomainDomain
IPR017983 GPCR, family 2, secretin-like, conserved siteSiteConserved site
IPR036445 GPCR family 2, extracellular hormone receptor domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00017 Salmon calcitoninDrugbankbiotech
DB01278 PramlintideDrugbanksmall molecule