Entity Details

Primary name CNOT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionA5YKK6
EntryNameCNOT1_HUMAN
FullNameCCR4-NOT transcription complex subunit 1
TaxID9606
Evidenceevidence at protein level
Length2376
SequenceStatuscomplete
DateCreated2008-01-15
DateModified2021-06-02

Ontological Relatives

GenesCNOT1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000932 P-body
GO:0001829 trophectodermal cell differentiation
GO:0003723 RNA binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005778 peroxisomal membrane
GO:0005829 cytosol
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly
GO:0016020 membrane
GO:0017148 negative regulation of translation
GO:0019904 protein domain specific binding
GO:0030014 CCR4-NOT complex
GO:0030015 CCR4-NOT core complex
GO:0030331 estrogen receptor binding
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0035195 gene silencing by miRNA
GO:0042974 retinoic acid receptor binding
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0060090 molecular adaptor activity
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0061014 positive regulation of mRNA catabolic process
GO:0070016 armadillo repeat domain binding
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2000036 regulation of stem cell population maintenance

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR007196 CCR4-Not complex component, Not1, C-terminalDomainDomain
IPR016021 MIF4G-like domain superfamilyFamilyHomologous superfamily
IPR024557 CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819DomainDomain
IPR032191 CCR4-NOT transcription complex subunit 1, CAF1-binding domainDomainDomain
IPR032193 CCR4-NOT transcription complex subunit 1, TTP binding domainDomainDomain
IPR032194 CCR4-NOT transcription complex subunit 1, HEAT repeatDomainDomain
IPR038535 CCR4-NOT subunit 1, TTP binding domain superfamilyFamilyHomologous superfamily
IPR040398 CCR4-NOT transcription complex subunit 1FamilyFamily

Diseases

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Disease IDSourceNameDescription
619033 OMIMVissers-Bodmer syndrome (VIBOS)An autosomal dominant disorder characterized by global developmental delay, intellectual disability of varying degree, speech delay, motor delay, and hypotonia. Abnormal growth, and cerebral, skeletal, muscle and soft tissue abnormalities are frequently observed. Many patients have behavioral problems, including anxiety, obsessive compulsive disorder, autism spectrum disorder and attention-deficit hyperactivity disorder. The disease may be caused by variants affecting the gene represented in this entry.
618500 OMIMHoloprosencephaly 12 with or without pancreatic agenesis (HPE12)An autosomal dominant form of holoprosencephaly, a structural anomaly of the brain in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. HPE12 clinical features include abnormal forebrain development, dysmorphic features, global developmental delay, learning difficulties, and congenital absence of the pancreas in most patients, resulting in early-onset insulin-dependent diabetes mellitus. Other features may include hearing loss and absence of the gallbladder. The disease may be caused by variants affecting the gene represented in this entry.

Interactions

64 interactions

InteractorPartnerSourcesPublicationsLink
CNOT1_HUMANCNOT2_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10637334 16778766 26496610 27173435 29395067 unassigned1312 details
CNOT1_HUMANCNOT8_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10637334 16778766 17353931 22977175 26496610 details
CNOT1_HUMANRXRA_HUMANBioGRID, HPRD, MINT16778766 details
CNOT1_HUMANTHB_HUMANHPRD, MINT16778766 details
CNOT1_HUMANCNO11_HUMANBioGRID, IntAct, UniProt23232451 26496610 28514442 29395067 details
CNOT1_HUMANCNOT4_HUMANBioGRID, HPRD, UniProt10637334 11823428 29802328 30692204 details
CNOT1_HUMANCNOT7_HUMANBioGRID, IntAct, UniProt21278420 22977175 26186194 26344197 26496610 28514442 29395067 details
CNOT1_HUMANTNR6A_HUMANBioGRID, UniProt21981923 21984185 23172285 24768540 28813667 29395067 details
CNOT1_HUMANTNR6C_HUMANBioGRID, DIP, MINT, UniProt21981923 21984184 21984185 23463101 29395067 details
CNOT1_HUMANTNR6B_HUMANBioGRID, UniProt21981923 29395067 details
CNOT1_HUMANCNOT1_HUMANUniProt22977175 details
CNOT1_HUMANCNOT9_HUMANBioGRID, IntAct22939629 24768540 26344197 26496610 29395067 details
CNOT1_HUMANNANO2_HUMANBioGRID, IntAct24736845 28514442 details
CNOT1_HUMANTTP_HUMANBioGRID, DIP23644599 29395067 details
CNOT1_HUMANNANO1_HUMANBioGRID24736845 details
CNOT1_HUMANNANO3_HUMANBioGRID24736845 details
CNOT1_HUMANDDX6_HUMANBioGRID24768540 29395067 details
CNOT1_HUMANCDC42_HUMANBioGRID31478661 details
CNOT1_HUMANRARA_HUMANHPRD16778766 details
CNOT1_HUMANPPARG_HUMANHPRD16778766 details
CNOT1_HUMANCNOT3_HUMANBioGRID, HPRD, IntAct, MINT16778766 22939629 26344197 26496610 29395067 details
CNOT1_HUMANTOB1_HUMANBioGRID, IntAct, UniProt18377426 26496610 28514442 details
CNOT1_HUMANCNO6L_HUMANBioGRID, DIP, IntAct, UniProt17452450 21984185 22977175 26496610 29395067 details
CNOT1_HUMANCNOT6_HUMANIntAct, UniProt17452450 22977175 26496610 unassigned1312 details
CNOT1_HUMANAGO2_HUMANBioGRID, UniProt21981923 28813667 29395067 details
CNOT1_HUMANOBI1_HUMANBioGRID, IntAct24778252 26496610 29395067 details
CNOT1_HUMANMEX3C_HUMANBioGRID26471122 details
CNOT1_HUMANRC3H1_HUMANBioGRID26170170 29395067 30209976 32460013 details
CNOT1_HUMANRPB1_HUMANBioGRID29802328 details
CNOT1_HUMANMED14_HUMANBioGRID28813667 details
CNOT1_HUMANZ3H7A_HUMANBioGRID29395067 30995489 details
CNOT1_HUMANLG3BP_HUMANBioGRID30833792 details
CNOT1_HUMANSTAU1_HUMANBioGRID29395067 30948266 details
CNOT1_HUMANMARF1_HUMANBioGRID29395067 details
CNOT1_HUMANMEX3B_HUMANBioGRID29395067 details
CNOT1_HUMANMKRN2_HUMANBioGRID29395067 details
CNOT1_HUMANMOV10_HUMANBioGRID29395067 details
CNOT1_HUMANNUFP2_HUMANBioGRID29395067 details
CNOT1_HUMANPABP1_HUMANBioGRID29395067 details
CNOT1_HUMANPAIP1_HUMANBioGRID29395067 details
CNOT1_HUMANPAIP2_HUMANBioGRID29395067 details
CNOT1_HUMANPATL1_HUMANBioGRID29395067 details
CNOT1_HUMANPRC2A_HUMANBioGRID29395067 details
CNOT1_HUMANPUM1_HUMANBioGRID29395067 details
CNOT1_HUMANR3HD2_HUMANBioGRID29395067 details
CNOT1_HUMANRBMS1_HUMANBioGRID29395067 details
CNOT1_HUMANRN214_HUMANBioGRID29395067 details
CNOT1_HUMANSMAG2_HUMANBioGRID29395067 details
CNOT1_HUMANENTR1_HUMANBioGRID29395067 details
CNOT1_HUMANSMAP2_HUMANBioGRID29395067 details
CNOT1_HUMANSMG7_HUMANBioGRID29395067 details
CNOT1_HUMANTDRD3_HUMANBioGRID29395067 details
CNOT1_HUMANUBP2L_HUMANBioGRID29395067 details
CNOT1_HUMANUNK_HUMANBioGRID29395067 details
CNOT1_HUMANXRN1_HUMANBioGRID29395067 details
CNOT1_HUMANYTHD1_HUMANBioGRID29395067 details
CNOT1_HUMANYTHD2_HUMANBioGRID29395067 details
CNOT1_HUMANYTHD3_HUMANBioGRID29395067 details
CNOT1_HUMANZCCHV_HUMANBioGRID29395067 details
CNOT1_HUMANTBB3_HUMANBioGRID29395067 details
CNOT1_HUMANTXNL1_HUMANBioGRID29395067 details
CNOT1_HUMANDCP1A_HUMANBioGRID29395067 details
CNOT1_HUMANPRC2B_HUMANBioGRID29395067 details
CNOT1_HUMANEST1A_HUMANBioGRID29395067 details