Entity Details

Primary name GLYM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP34897
EntryNameGLYM_HUMAN
FullNameSerine hydroxymethyltransferase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length504
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesSHMT2

GO terms

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GOName
GO:0000900 translation repressor activity, mRNA regulatory element binding
GO:0002082 regulation of oxidative phosphorylation
GO:0003682 chromatin binding
GO:0004372 glycine hydroxymethyltransferase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006544 glycine metabolic process
GO:0006563 L-serine metabolic process
GO:0006564 L-serine biosynthetic process
GO:0006565 L-serine catabolic process
GO:0006730 one-carbon metabolic process
GO:0008270 zinc ion binding
GO:0008284 positive regulation of cell population proliferation
GO:0008732 L-allo-threonine aldolase activity
GO:0009113 purine nucleobase biosynthetic process
GO:0015630 microtubule cytoskeleton
GO:0019264 glycine biosynthetic process from serine
GO:0030170 pyridoxal phosphate binding
GO:0034340 response to type I interferon
GO:0035999 tetrahydrofolate interconversion
GO:0042645 mitochondrial nucleoid
GO:0042803 protein homodimerization activity
GO:0046653 tetrahydrofolate metabolic process
GO:0046655 folic acid metabolic process
GO:0048027 mRNA 5'-UTR binding
GO:0050897 cobalt ion binding
GO:0051262 protein tetramerization
GO:0051289 protein homotetramerization
GO:0070062 extracellular exosome
GO:0070129 regulation of mitochondrial translation
GO:0070536 protein K63-linked deubiquitination
GO:0070552 BRISC complex
GO:0070905 serine binding
GO:1903715 regulation of aerobic respiration

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Mitochondrion inner membrane
Mitochondrion matrix
Nucleus

Domains

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DomainNameCategoryType
IPR001085 Serine hydroxymethyltransferaseFamilyFamily
IPR015421 Pyridoxal phosphate-dependent transferase, major domainFamilyHomologous superfamily
IPR015422 Pyridoxal phosphate-dependent transferase, small domainFamilyHomologous superfamily
IPR015424 Pyridoxal phosphate-dependent transferaseFamilyHomologous superfamily
IPR019798 Serine hydroxymethyltransferase, pyridoxal phosphate binding siteSiteBinding site
IPR039429 Serine hydroxymethyltransferase-like domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule
DB00116 Tetrahydrofolic acidDrugbanksmall molecule
DB00145 GlycineDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
GLYM_HUMANA4_HUMANBioGRID21832049 details
GLYM_HUMANCKLF5_HUMANBioGRID, IntAct25416956 26871637 29892012 details
GLYM_HUMANAR6P1_HUMANBioGRID, IntAct25416956 26871637 details
GLYM_HUMANGLYM_HUMANBioGRID, HPRD11063567 31142841 details
GLYM_HUMANESR1_HUMANBioGRID20348541 details
GLYM_HUMANOGT1_HUMANBioGRID32994395 details
GLYM_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
GLYM_HUMANBABA2_HUMANBioGRID, IntAct19615732 28514442 31253574 details
GLYM_HUMANBRCC3_HUMANBioGRID, IntAct19615732 28514442 31253574 details
GLYM_HUMANABRX2_HUMANBioGRID, IntAct24075985 28514442 31142841 31253574 details
GLYM_HUMANCLC2D_HUMANBioGRID, IntAct27107012 details
GLYM_HUMANFBX7_HUMANBioGRID27503909 details
GLYM_HUMANMAL2_HUMANBioGRID, IntAct26871637 details
GLYM_HUMANBABA1_HUMANBioGRID, IntAct19615732 26186194 28514442 31253574 details
GLYM_HUMANCREB3_HUMANBioGRID, MINT21516116 22658674 details
GLYM_HUMANKASH5_HUMANBioGRID, IntAct27107012 details
GLYM_HUMANCAB39_HUMANBioGRID, IntAct32296183 details
GLYM_HUMANKIRR3_HUMANIntAct25902260 details
GLYM_HUMANPPARD_HUMANBioGRID15604093 details
GLYM_HUMANIF6_HUMANIntAct17353931 details
GLYM_HUMANDYL2_HUMANBioGRID, IntAct27173435 unassigned1312 details
GLYM_HUMANU2AF2_HUMANBioGRID24981860 26641092 details
GLYM_HUMANDYL1_HUMANBioGRID, IntAct27173435 unassigned1312 details
GLYM_HUMANDEGS1_HUMANIntAct17353931 details
GLYM_HUMANIKKE_HUMANIntAct17353931 details
GLYM_HUMANINAR1_HUMANBioGRID24075985 details
GLYM_HUMANCSK2B_HUMANHPRD10549165 details
GLYM_HUMANHLAB_HUMANIntAct17353931 details
GLYM_HUMANHDAC5_HUMANBioGRID21081666 details
GLYM_HUMANTR10D_HUMANIntAct17353931 details
GLYM_HUMANAAKB1_HUMANIntAct17353931 details