Entity Details

Primary name SFTPD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35247
EntryNameSFTPD_HUMAN
FullNamePulmonary surfactant-associated protein D
TaxID9606
Evidenceevidence at protein level
Length375
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesSFTPD

GO terms

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GOName
GO:0001817 regulation of cytokine production
GO:0002224 toll-like receptor signaling pathway
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005771 multivesicular body
GO:0005789 endoplasmic reticulum membrane
GO:0005791 rough endoplasmic reticulum
GO:0006898 receptor-mediated endocytosis
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0030139 endocytic vesicle
GO:0030246 carbohydrate binding
GO:0032703 negative regulation of interleukin-2 production
GO:0042130 negative regulation of T cell proliferation
GO:0042742 defense response to bacterium
GO:0043129 surfactant homeostasis
GO:0043152 induction of bacterial agglutination
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response
GO:0045334 clathrin-coated endocytic vesicle
GO:0048246 macrophage chemotaxis
GO:0048286 lung alveolus development
GO:0050766 positive regulation of phagocytosis
GO:0050776 regulation of immune response
GO:0052405 negative regulation by host of symbiont molecular function
GO:0072593 reactive oxygen species metabolic process
GO:1905226 regulation of adhesion of symbiont to host epithelial cell

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001304 C-type lectin-likeDomainDomain
IPR008160 Collagen triple helix repeatRepeatRepeat
IPR015097 Lung surfactant protein D coiled-coil trimerisationDomainDomain
IPR016186 C-type lectin-like/link domain superfamilyFamilyHomologous superfamily
IPR016187 C-type lectin foldFamilyHomologous superfamily
IPR018378 C-type lectin, conserved siteSiteConserved site
IPR033990 Collectin, C-type lectin-like domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB02379 Beta-D-GlucoseDrugbanksmall molecule