Entity Details

Primary name TPO_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP40225
EntryNameTPO_HUMAN
FullNameThrombopoietin
TaxID9606
Evidenceevidence at protein level
Length353
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesTHPO

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0005102 signaling receptor binding
GO:0005125 cytokine activity
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0007275 multicellular organism development
GO:0008083 growth factor activity
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0035855 megakaryocyte development
GO:0038163 thrombopoietin-mediated signaling pathway
GO:0043410 positive regulation of MAPK cascade
GO:0045654 positive regulation of megakaryocyte differentiation
GO:0051897 positive regulation of protein kinase B signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0097696 receptor signaling pathway via STAT
GO:1902035 positive regulation of hematopoietic stem cell proliferation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001323 Erythropoietin/thrombopoietinFamilyFamily
IPR003978 ThrombopoietinFamilyFamily
IPR009079 Four-helical cytokine-like, coreFamilyHomologous superfamily
IPR019767 Erythropoietin/thrombopoeitin, conserved siteSiteConserved site

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
TPO_HUMANEP300_HUMANBioGRID, IntAct21988832 details
TPO_HUMANNUMBL_HUMANBioGRID, IntAct21988832 details
TPO_HUMANAPH1A_HUMANBioGRID, IntAct21988832 details
TPO_HUMANTPOR_HUMANHPRD9766811 details