Entity Details

Primary name IF2G_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41091
EntryNameIF2G_HUMAN
FullNameEukaryotic translation initiation factor 2 subunit 3
TaxID9606
Evidenceevidence at protein level
Length472
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesEIF2S3

GO terms

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GOName
GO:0000049 tRNA binding
GO:0001731 formation of translation preinitiation complex
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0006413 translational initiation
GO:0008135 translation factor activity, RNA binding
GO:0045296 cadherin binding
GO:0045903 positive regulation of translational fidelity
GO:0055085 transmembrane transport
GO:0070062 extracellular exosome

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000795 Translational (tr)-type GTP-binding domainDomainDomain
IPR004161 Translation elongation factor EFTu-like, domain 2DomainDomain
IPR009000 Translation protein, beta-barrel domain superfamilyFamilyHomologous superfamily
IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminalFamilyHomologous superfamily
IPR015256 Initiation factor eIF2 gamma, C-terminalDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR044127 Initiation factor eIF2 gamma, domain 2DomainDomain
IPR044128 Initiation factor eIF2 gamma, GTP-binding domainDomainDomain

Diseases

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Disease IDSourceNameDescription
300148 OMIMMEHMO syndrome (MEHMO)An X-linked recessive mental retardation syndrome characterized by intellectual disability, epileptic seizures, hypogonadism and hypogenitalism, microcephaly, and obesity. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB04315 Guanosine-5'-DiphosphateDrugbanksmall molecule

Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
IF2G_HUMANIF2B_HUMANBioGRID, IntAct16288713 26186194 26344197 28514442 details
IF2G_HUMANIF2A_HUMANBioGRID, IntAct16288713 22863883 22939629 26344197 30699057 details
IF2G_HUMANINCA1_HUMANIntAct32814053 details
IF2G_HUMANZN829_HUMANIntAct32814053 details
IF2G_HUMANSPT12_HUMANIntAct32814053 details
IF2G_HUMANPELI3_HUMANIntAct32814053 details
IF2G_HUMANSPAS1_HUMANIntAct32814053 details
IF2G_HUMANMET15_HUMANIntAct32814053 details
IF2G_HUMANADAL_HUMANIntAct32814053 details
IF2G_HUMANTAF8_HUMANIntAct32814053 details
IF2G_HUMANZKSC3_HUMANIntAct32814053 details
IF2G_HUMANFAKD1_HUMANIntAct32814053 details
IF2G_HUMANOTU7B_HUMANIntAct32814053 details
IF2G_HUMANASIC4_HUMANIntAct32814053 details
IF2G_HUMANWBP1L_HUMANIntAct32814053 details
IF2G_HUMANMOG1_HUMANIntAct32814053 details
IF2G_HUMANLAR4B_HUMANIntAct32814053 details
IF2G_HUMANBAHD1_HUMANIntAct32814053 details
IF2G_HUMANRASF1_HUMANIntAct32814053 details
IF2G_HUMANRPC6_HUMANIntAct32814053 details
IF2G_HUMANHNRPQ_HUMANIntAct32814053 details
IF2G_HUMANDPF1_HUMANIntAct32814053 details
IF2G_HUMANUBE2A_HUMANIntAct32814053 details
IF2G_HUMANPER1_HUMANIntAct32814053 details
IF2G_HUMANM3K5_HUMANIntAct32814053 details
IF2G_HUMANCDN1A_HUMANIntAct32814053 details
IF2G_HUMANGABP1_HUMANIntAct32814053 details
IF2G_HUMANHD_HUMANIntAct32814053 details
IF2G_HUMANIKKE_HUMANIntAct17353931 details
IF2G_HUMANSOMA_HUMANIntAct17353931 details
IF2G_HUMANHLAB_HUMANIntAct17353931 details
IF2G_HUMANAAKB1_HUMANIntAct17353931 details
IF2G_HUMANTRAF6_HUMANIntAct17353931 details
IF2G_HUMANCA131_HUMANBioGRID26472760 details
IF2G_HUMANANM7_HUMANBioGRID30699057 details
IF2G_HUMANMAP2_HUMANHPRD8098621 details