Entity Details

Primary name LEP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41159
EntryNameLEP_HUMAN
FullNameLeptin
TaxID9606
Evidenceevidence at protein level
Length167
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesLEP

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001525 angiogenesis
GO:0001542 ovulation from ovarian follicle
GO:0001666 response to hypoxia
GO:0001890 placenta development
GO:0001934 positive regulation of protein phosphorylation
GO:0001936 regulation of endothelial cell proliferation
GO:0002021 response to dietary excess
GO:0003300 cardiac muscle hypertrophy
GO:0003677 DNA binding
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0006006 glucose metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006112 energy reserve metabolic process
GO:0006114 glycerol biosynthetic process
GO:0006629 lipid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0006909 phagocytosis
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0007565 female pregnancy
GO:0007623 circadian rhythm
GO:0008203 cholesterol metabolic process
GO:0008206 bile acid metabolic process
GO:0008217 regulation of blood pressure
GO:0008340 determination of adult lifespan
GO:0008343 adult feeding behavior
GO:0010507 negative regulation of autophagy
GO:0010888 negative regulation of lipid storage
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014823 response to activity
GO:0019953 sexual reproduction
GO:0021954 central nervous system neuron development
GO:0030073 insulin secretion
GO:0030217 T cell differentiation
GO:0030300 regulation of intestinal cholesterol absorption
GO:0032008 positive regulation of TOR signaling
GO:0032099 negative regulation of appetite
GO:0032310 prostaglandin secretion
GO:0032355 response to estradiol
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032814 regulation of natural killer cell activation
GO:0032817 regulation of natural killer cell proliferation
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0033197 response to vitamin E
GO:0033210 leptin-mediated signaling pathway
GO:0033686 positive regulation of luteinizing hormone secretion
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035556 intracellular signal transduction
GO:0035630 bone mineralization involved in bone maturation
GO:0035904 aorta development
GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0042269 regulation of natural killer cell mediated cytotoxicity
GO:0042307 positive regulation of protein import into nucleus
GO:0042445 hormone metabolic process
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042593 glucose homeostasis
GO:0042755 eating behavior
GO:0043066 negative regulation of apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0044320 cellular response to leptin stimulus
GO:0045471 response to ethanol
GO:0045765 regulation of angiogenesis
GO:0045906 negative regulation of vasoconstriction
GO:0046325 negative regulation of glucose import
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046850 regulation of bone remodeling
GO:0046881 positive regulation of follicle-stimulating hormone secretion
GO:0048639 positive regulation of developmental growth
GO:0050796 regulation of insulin secretion
GO:0050810 regulation of steroid biosynthetic process
GO:0050892 intestinal absorption
GO:0050901 leukocyte tethering or rolling
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051428 peptide hormone receptor binding
GO:0051541 elastin metabolic process
GO:0051726 regulation of cell cycle
GO:0051897 positive regulation of protein kinase B signaling
GO:0060587 regulation of lipoprotein lipid oxidation
GO:0060612 adipose tissue development
GO:0061037 negative regulation of cartilage development
GO:0070093 negative regulation of glucagon secretion
GO:0071298 cellular response to L-ascorbic acid
GO:0071300 cellular response to retinoic acid
GO:0090335 regulation of brown fat cell differentiation
GO:0098868 bone growth
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1900015 regulation of cytokine production involved in inflammatory response
GO:1900745 positive regulation of p38MAPK cascade
GO:1904651 positive regulation of fat cell apoptotic process
GO:1990051 activation of protein kinase C activity
GO:1990460 leptin receptor binding
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000486 negative regulation of glutamine transport
GO:2000491 positive regulation of hepatic stellate cell activation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000065 LeptinFamilyFamily
IPR009079 Four-helical cytokine-like, coreFamilyHomologous superfamily

Diseases

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