Entity Details

Primary name MAP1B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP46821
EntryNameMAP1B_HUMAN
FullNameMicrotubule-associated protein 1B
TaxID9606
Evidenceevidence at protein level
Length2468
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesMAP1B

GO terms

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GOName
GO:0000226 microtubule cytoskeleton organization
GO:0001578 microtubule bundle formation
GO:0001750 photoreceptor outer segment
GO:0001764 neuron migration
GO:0003779 actin binding
GO:0005198 structural molecule activity
GO:0005543 phospholipid binding
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0005886 plasma membrane
GO:0007026 negative regulation of microtubule depolymerization
GO:0007409 axonogenesis
GO:0007416 synapse assembly
GO:0008017 microtubule binding
GO:0009612 response to mechanical stimulus
GO:0009743 response to carbohydrate
GO:0009987 cellular process
GO:0010035 response to inorganic substance
GO:0014012 peripheral nervous system axon regeneration
GO:0014069 postsynaptic density
GO:0016358 dendrite development
GO:0017085 response to insecticide
GO:0021700 developmental maturation
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0031114 regulation of microtubule depolymerization
GO:0031116 positive regulation of microtubule polymerization
GO:0032355 response to estradiol
GO:0032387 negative regulation of intracellular transport
GO:0033189 response to vitamin A
GO:0036477 somatodendritic compartment
GO:0042493 response to drug
GO:0043025 neuronal cell body
GO:0043196 varicosity
GO:0043197 dendritic spine
GO:0043204 perikaryon
GO:0044877 protein-containing complex binding
GO:0045202 synapse
GO:0045666 positive regulation of neuron differentiation
GO:0045773 positive regulation of axon extension
GO:0047497 mitochondrion transport along microtubule
GO:0048471 perinuclear region of cytoplasm
GO:0048675 axon extension
GO:0051915 induction of synaptic plasticity by chemical substance
GO:0061162 establishment of monopolar cell polarity
GO:0071363 cellular response to growth factor stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:0097440 apical dendrite
GO:0097441 basal dendrite
GO:0097457 hippocampal mossy fiber

Subcellular Location

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Subcellular Location
Cell junction
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR000102 Neuraxin/MAP1B repeatRepeatRepeat
IPR026074 Microtubule associated protein 1FamilyFamily
IPR027321 Microtubule-associated protein 1BFamilyFamily

Diseases

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Disease IDSourceNameDescription
618918 OMIMPeriventricular nodular heterotopia 9 (PVNH9)A form of periventricular nodular heterotopia, a disorder resulting from a defect in the pattern of neuronal migration in which ectopic collections of neurons lie along the lateral ventricles of the brain or just beneath, contiguously or in isolated patches. PVNH9 is an autosomal dominant disorder with incomplete penetrance, characterized by impaired intellectual development, cognitive defects, learning disabilities, and behavior abnormalities. Some patients develop seizures. The disease is caused by variants affecting the gene represented in this entry.

Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
MAP1B_HUMANGAN_HUMANBioGRID, HPRD, MINT12147674 details
MAP1B_HUMANFOS_HUMANBioGRID, IntAct20195357 details
MAP1B_HUMANEF1D_HUMANBioGRID, IntAct20195357 28514442 details
MAP1B_HUMANPP1A_HUMANUniProt19389623 details
MAP1B_HUMANRASF1_HUMANBioGRID, HPRD, IntAct15205320 24366813 26186194 28514442 details
MAP1B_HUMAN5HT6R_HUMANBioGRID, IntAct24614691 details
MAP1B_HUMANERBB3_HUMANBioGRID, IntAct31980649 details
MAP1B_HUMANHMGB1_HUMANUniProt31694235 details
MAP1B_HUMANAN32A_HUMANBioGRID, HPRD12807913 details
MAP1B_HUMANSYUA_HUMANBioGRID, HPRD10764738 details
MAP1B_HUMANOSTP_HUMANBioGRID22779921 details
MAP1B_HUMANMARH5_HUMANBioGRID22308378 details
MAP1B_HUMANLRRK2_HUMANBioGRID21159966 details
MAP1B_HUMANPARK7_HUMANBioGRID21645326 details
MAP1B_HUMANCBP_HUMANBioGRID32238831 details
MAP1B_HUMANARHGB_HUMANHPRD16478718 details
MAP1B_HUMANNXF1_HUMANHPRD16014633 details
MAP1B_HUMANMINK1_HUMANHPRD15032605 details
MAP1B_HUMANP53_HUMANMINT18656471 details
MAP1B_HUMANSCHI1_HUMANIntAct20195357 details
MAP1B_HUMANPHB_HUMANBioGRID, IntAct20195357 27025967 details
MAP1B_HUMANPHS_HUMANIntAct20195357 details
MAP1B_HUMANMTEF1_HUMANIntAct20195357 details
MAP1B_HUMANMAG_HUMANBioGRID, HPRD11733546 details
MAP1B_HUMANHDAC5_HUMANBioGRID21081666 details
MAP1B_HUMANMGN_HUMANBioGRID, HPRD16014633 23084401 details
MAP1B_HUMANABCE1_HUMANBioGRID25659154 details
MAP1B_HUMANNSD2_HUMANBioGRID24923560 details
MAP1B_HUMANCAC1B_HUMANBioGRID25483588 details
MAP1B_HUMANCAC1A_HUMANBioGRID25483588 details
MAP1B_HUMANATOH1_HUMANBioGRID27542412 details
MAP1B_HUMANARRD3_HUMANBioGRID29416926 details
MAP1B_HUMANSOX2_HUMANBioGRID21280222 details
MAP1B_HUMANLIS1_HUMANHPRD15762842 details
MAP1B_HUMANGSK3B_HUMANHPRD9570753 details
MAP1B_HUMANSTAU1_HUMANHPRD16014633 details
MAP1B_HUMANSTRAP_HUMANHPRD16014633 details
MAP1B_HUMANU2AF5_HUMANHPRD16014633 details
MAP1B_HUMANU2AF1_HUMANHPRD16014633 details
MAP1B_HUMANU2AF2_HUMANHPRD16014633 details
MAP1B_HUMANACTB_HUMANHPRD9813091 details
MAP1B_HUMANMAP1A_HUMANHPRD11002287 2470876 details
MAP1B_HUMANMK08_HUMANHPRD12689591 details
MAP1B_HUMANDYL1_HUMANHPRD14760703 details
MAP1B_HUMANGBRR1_HUMANHPRD11102469 9892354 details
MAP1B_HUMANGBRR2_HUMANHPRD11102469 details