Entity Details

Primary name RFX3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48380
EntryNameRFX3_HUMAN
FullNameTranscription factor RFX3
TaxID9606
Evidenceevidence at protein level
Length749
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesRFX3

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0031018 endocrine pancreas development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048469 cell maturation
GO:0050796 regulation of insulin secretion
GO:0060271 cilium assembly
GO:0060285 cilium-dependent cell motility
GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry
GO:0072560 type B pancreatic cell maturation
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000078 positive regulation of type B pancreatic cell development

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR003150 DNA-binding RFX-type winged-helix domainDomainDomain
IPR007668 RFX1 transcription activation regionDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR039779 RFX-like DNA-binding proteinFamilyFamily

Diseases

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Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
RFX3_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct16189514 29892012 32296183 details
RFX3_HUMANRFX6_HUMANBioGRID, HPRD, IntAct16189514 details
RFX3_HUMANFHL2_HUMANBioGRID, IntAct, MINT21516116 25416956 29892012 31515488 32296183 details
RFX3_HUMANFHL3_HUMANBioGRID, IntAct25416956 31515488 details
RFX3_HUMANTRIP6_HUMANBioGRID, IntAct25416956 details
RFX3_HUMANEWS_HUMANBioGRID, IntAct20211142 details
RFX3_HUMANCREB1_HUMANBioGRID, IntAct20211142 details
RFX3_HUMANPKNX1_HUMANBioGRID, IntAct20211142 details
RFX3_HUMANIRF6_HUMANBioGRID, IntAct20211142 details
RFX3_HUMANBIN1_HUMANBioGRID, IntAct20211142 details
RFX3_HUMANMEOX2_HUMANBioGRID32296183 details
RFX3_HUMANFOXJ1_HUMANBioGRID, IntAct, MINT25609649 27173435 28514442 unassigned1312 details
RFX3_HUMANTMED4_HUMANBioGRID, IntAct27173435 unassigned1312 details
RFX3_HUMANRFX1_HUMANBioGRID, HPRD, IntAct10330134 27173435 unassigned1312 details
RFX3_HUMANVPS45_HUMANBioGRID, IntAct27173435 unassigned1312 details
RFX3_HUMANMTA2_HUMANBioGRID, IntAct27173435 unassigned1312 details
RFX3_HUMANPLK1_HUMANBioGRID, IntAct27173435 unassigned1312 details
RFX3_HUMANHDAC1_HUMANBioGRID, IntAct27173435 unassigned1312 details
RFX3_HUMANPTOV1_HUMANBioGRID, IntAct27173435 unassigned1312 details
RFX3_HUMANCDK20_HUMANBioGRID, IntAct27173435 unassigned1312 details
RFX3_HUMANDDX1_HUMANBioGRID, IntAct27173435 unassigned1312 details
RFX3_HUMANHDAC2_HUMANBioGRID, IntAct27173435 unassigned1312 details
RFX3_HUMANBROMI_HUMANBioGRID, IntAct27173435 unassigned1312 details
RFX3_HUMANXYLT2_HUMANBioGRID, IntAct27173435 unassigned1312 details
RFX3_HUMANACAD9_HUMANBioGRID, IntAct27173435 unassigned1312 details
RFX3_HUMANMBD2_HUMANBioGRID, IntAct27173435 unassigned1312 details
RFX3_HUMANRTCB_HUMANBioGRID, IntAct27173435 unassigned1312 details
RFX3_HUMANTAF6L_HUMANBioGRID, IntAct27173435 unassigned1312 details
RFX3_HUMANCFA20_HUMANBioGRID, IntAct27173435 unassigned1312 details
RFX3_HUMANRFX4_HUMANBioGRID, HPRD11682486 details
RFX3_HUMANSOX2_HUMANBioGRID21532573 details
RFX3_HUMANRFX3_HUMANHPRD10330134 details