Entity Details

Primary name SYSC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49591
EntryNameSYSC_HUMAN
FullNameSerine--tRNA ligase, cytoplasmic
TaxID9606
Evidenceevidence at protein level
Length514
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesSARS1

GO terms

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GOName
GO:0000049 tRNA binding
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003723 RNA binding
GO:0004828 serine-tRNA ligase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006434 seryl-tRNA aminoacylation
GO:0008033 tRNA processing
GO:0016259 selenocysteine metabolic process
GO:0016525 negative regulation of angiogenesis
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0070062 extracellular exosome
GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process
GO:1904046 negative regulation of vascular endothelial growth factor production

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)DomainDomain
IPR002317 Serine-tRNA ligase, type1FamilyFamily
IPR006195 Aminoacyl-tRNA synthetase, class IIDomainDomain
IPR010978 Class I and II aminoacyl-tRNA synthetase, tRNA-binding armFamilyHomologous superfamily
IPR015866 Serine-tRNA synthetase, type1, N-terminalDomainDomain
IPR033729 Serine-tRNA ligase catalytic core domainDomainDomain
IPR042103 Serine-tRNA synthetase, type1, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00133 SerineDrugbanksmall molecule