Entity Details

Primary name MCM2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49736
EntryNameMCM2_HUMAN
FullNameDNA replication licensing factor MCM2
TaxID9606
Evidenceevidence at protein level
Length904
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesMCM2

GO terms

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GOName
GO:0000727 double-strand break repair via break-induced replication
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005664 nuclear origin of replication recognition complex
GO:0005737 cytoplasm
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006334 nucleosome assembly
GO:0006915 apoptotic process
GO:0016787 hydrolase activity
GO:0019899 enzyme binding
GO:0036388 pre-replicative complex assembly
GO:0042393 histone binding
GO:0042555 MCM complex
GO:0046872 metal ion binding
GO:0071162 CMG complex
GO:0071353 cellular response to interleukin-4
GO:0090102 cochlea development
GO:1902975 mitotic DNA replication initiation
GO:1905775 negative regulation of DNA helicase activity

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR001208 MCM domainDomainDomain
IPR008045 DNA replication licensing factor Mcm2FamilyFamily
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR018525 Mini-chromosome maintenance, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR027925 MCM N-terminal domainDomainDomain
IPR031327 Mini-chromosome maintenance proteinFamilyFamily
IPR033762 MCM OB domainDomainDomain
IPR041562 MCM, AAA-lid domainDomainDomain

Diseases

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Interactions

118 interactions

InteractorPartnerSourcesPublicationsLink
MCM2_HUMANORC2_HUMANBioGRID, HPRD, IntAct12614612 15232106 details
MCM2_HUMANMCM7_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10567526 10748114 12207017 12614612 12694531 15232106 16899510 17296731 22540012 22863883 22939629 23764002 25963833 26186194 26344197 27173435 30100344 8798650 9099751 unassigned1312 details
MCM2_HUMANORC5_HUMANBioGRID, HPRD, IntAct12614612 15232106 details
MCM2_HUMANCDK4_HUMANBioGRID, HPRD, IntAct15232106 details
MCM2_HUMANMCM6_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt10567526 12207017 12614612 12694531 16189514 16899510 17296731 20211142 22540012 22863883 22939629 25416956 25963833 26167883 26344197 26496610 27173435 30100344 unassigned1312 details
MCM2_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
MCM2_HUMANASF1A_HUMANBioGRID, DIP, IntAct, MINT22407294 23602572 24981860 25963833 26167883 28514442 32296183 details
MCM2_HUMANATM_HUMANBioGRID15210935 details
MCM2_HUMANMCPH1_HUMANBioGRID19525936 details
MCM2_HUMANCDT1_HUMANBioGRID21930785 details
MCM2_HUMANSLD5_HUMANBioGRID22374673 27592030 30392930 details
MCM2_HUMANMCM3_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt12614612 15232106 16899510 17296731 22540012 23993743 25963833 26167883 26344197 27621311 28514442 30108253 31467278 details
MCM2_HUMANMCM5_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11248027 12614612 15232106 16899510 17296731 22540012 22939629 23993743 24207054 25963833 26344197 details
MCM2_HUMANPHC2_HUMANBioGRID, HPRD, IntAct16169070 details
MCM2_HUMANEP300_HUMANBioGRID, MINT20808282 30110629 details
MCM2_HUMANMCM4_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10567526 12614612 12694531 16899510 16902406 17296731 22540012 22863883 22939629 23764002 25963833 26344197 27173435 8798650 unassigned1312 details
MCM2_HUMANRFA3_HUMANBioGRID, HPRD12614612 details
MCM2_HUMANCDN2A_HUMANBioGRID, IntAct15232106 details
MCM2_HUMANMPP3_HUMANBioGRID, HPRD, IntAct16169070 details
MCM2_HUMANCDC7_HUMANBioGRID, HPRD, UniProt10523313 10846177 11568184 12614612 16446360 16826239 16899510 17927916 18286467 22540012 23066029 30392930 details
MCM2_HUMANP2RX4_HUMANBioGRID, IntAct21988832 details
MCM2_HUMANARF_HUMANBioGRID, HPRD15232106 details
MCM2_HUMANCSK21_HUMANBioGRID, IntAct22113938 details
MCM2_HUMANCDC45_HUMANBioGRID, DIP19805216 22374673 26167883 30392930 details
MCM2_HUMANGNB5_HUMANBioGRID, HPRD, IntAct16169070 details
MCM2_HUMANRS4X_HUMANBioGRID, HPRD, IntAct16169070 25963833 details
MCM2_HUMANCDK2_HUMANBioGRID16446360 21319273 details
MCM2_HUMANPTEN_HUMANBioGRID31685992 details
MCM2_HUMANSNF8_HUMANBioGRID, MINT19819239 details
MCM2_HUMANMCM10_HUMANBioGRID, HPRD, IntAct11095689 15232106 details
MCM2_HUMANCDK6_HUMANBioGRID, HPRD, IntAct15232106 details
MCM2_HUMANCCNB2_HUMANBioGRID, HPRD, IntAct15232106 details
MCM2_HUMANAKAP8_HUMANBioGRID, HPRD, UniProt12740381 details
MCM2_HUMANCCNC_HUMANBioGRID12392551 details
MCM2_HUMANFBX7_HUMANBioGRID27503909 details
MCM2_HUMANMCM2_HUMANBioGRID, HPRD12614612 15232106 25963833 details
MCM2_HUMANA4_HUMANBioGRID21832049 details
MCM2_HUMANCDC6_HUMANBioGRID, HPRD, IntAct15232106 23405012 details
MCM2_HUMANPHOCN_HUMANBioGRID, HPRD, IntAct16169070 details
MCM2_HUMANORC1_HUMANBioGRID, HPRD12614612 details
MCM2_HUMANRFA1_HUMANBioGRID, HPRD12614612 25963833 details
MCM2_HUMANELL_HUMANBioGRID, MINT19819239 details
MCM2_HUMANDBF4A_HUMANBioGRID, HPRD10846177 12614612 18286467 22540012 details
MCM2_HUMANKAT7_HUMANBioGRID, HPRD11278932 16428461 details
MCM2_HUMANPSF3_HUMANBioGRID, DIP19805216 26186194 details
MCM2_HUMANTE2IP_HUMANbhf-ucl, BioGRID21044950 details
MCM2_HUMANORC4_HUMANBioGRID, HPRD12614612 details
MCM2_HUMANRFA2_HUMANBioGRID, HPRD12614612 details
MCM2_HUMANSIK1_HUMANBioGRID27592030 details
MCM2_HUMANORC6_HUMANBioGRID, HPRD, IntAct15232106 details
MCM2_HUMANATR_HUMANBioGRID15210935 details
MCM2_HUMANTCEA2_HUMANBioGRID12392551 details
MCM2_HUMANTBP_HUMANBioGRID, HPRD12392551 details
MCM2_HUMANESCO2_HUMANBioGRID30100344 details
MCM2_HUMANPHB_HUMANBioGRID19377303 details
MCM2_HUMANCHK1_HUMANBioGRID25049228 details
MCM2_HUMANH4_HUMANBioGRID, DIP, IntAct19862764 25963833 26167883 27248496 28514442 details
MCM2_HUMANGAPD1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANASF1B_HUMANBioGRID, DIP, IntAct, MINT20227376 24981860 25963833 26167883 26527279 28514442 details
MCM2_HUMANH31_HUMANBioGRID, DIP, IntAct25963833 26167883 26527279 28514442 details
MCM2_HUMANFACD2_HUMANBioGRID23993743 24658369 31180492 details
MCM2_HUMANTF2H1_HUMANHPRD12392551 details
MCM2_HUMANPLK1_HUMANBioGRID, HPRD, IntAct15654075 27173435 unassigned1312 details
MCM2_HUMANTF3C4_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANCENPA_HUMANDIP26167883 details
MCM2_HUMANRECQ4_HUMANBioGRID19696745 29229926 details
MCM2_HUMANSSRP1_HUMANBioGRID, IntAct, MINT16902406 21055985 24981860 28514442 details
MCM2_HUMANIKKE_HUMANIntAct17353931 details
MCM2_HUMANMCMBP_HUMANBioGRID, IntAct, MINT22540012 24299456 25036637 25963833 details
MCM2_HUMANSBNO1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANPP4R2_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANSOX4_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANANK3_HUMANBioGRID, IntAct25963833 27173435 unassigned1312 details
MCM2_HUMANPGK1_HUMANBioGRID25963833 30392930 details
MCM2_HUMANRAD52_HUMANBioGRID, HPRD15766559 details
MCM2_HUMANTONSL_HUMANBioGRID, MINT21055984 21055985 21113133 details
MCM2_HUMANCPSF1_HUMANHPRD12392551 details
MCM2_HUMANEP15R_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANH2A1B_HUMANBioGRID25963833 27248496 30104407 details
MCM2_HUMANAIRE_HUMANBioGRID20085707 details
MCM2_HUMANH2B1B_HUMANBioGRID25963833 27248496 30104407 details
MCM2_HUMANFANCI_HUMANBioGRID25843623 details
MCM2_HUMANPCNA_HUMANBioGRID32900933 details
MCM2_HUMANTF3C2_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANKEAP1_HUMANBioGRID27621311 details
MCM2_HUMANSMC3_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANUBP15_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANP4R3A_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANLMBL1_HUMANBioGRID, DIP, IntAct21149733 28514442 details
MCM2_HUMANCCL2_HUMANBioGRID21383955 details
MCM2_HUMANH31T_HUMANBioGRID, HPRD25963833 8798650 details
MCM2_HUMANCCNA1_HUMANIntAct17353931 details
MCM2_HUMANWEE1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANATG2B_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANSF3A1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANNS1BP_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANCD11A_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANSPRTN_HUMANBioGRID27871366 details
MCM2_HUMANJIP4_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANING5_HUMANBioGRID16387653 details
MCM2_HUMANMMS22_HUMANBioGRID21055985 details
MCM2_HUMANATRIP_HUMANBioGRID21775519 details
MCM2_HUMANRPB1_HUMANBioGRID10454562 details
MCM2_HUMANTCEA1_HUMANBioGRID10454562 details
MCM2_HUMANDPOLA_HUMANBioGRID11259605 details
MCM2_HUMANDONS_HUMANBioGRID28191891 details
MCM2_HUMANEMD_HUMANBioGRID17620012 details
MCM2_HUMANCCND1_HUMANBioGRID12519773 details
MCM2_HUMANRELCH_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANMGMT_HUMANBioGRID16226712 details
MCM2_HUMANSMC1A_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANTF2B_HUMANHPRD12392551 details
MCM2_HUMANBCR_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANHJURP_HUMANDIP26167883 details
MCM2_HUMANHSF1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM2_HUMANRN126_HUMANBioGRID26508657 details
MCM2_HUMANUBR5_HUMANBioGRID31586398 details
MCM2_HUMANHDAC5_HUMANBioGRID21081666 details