Entity Details

Primary name COMP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49747
EntryNameCOMP_HUMAN
FullNameCartilage oligomeric matrix protein
TaxID9606
Evidenceevidence at protein level
Length757
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesCOMP

GO terms

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GOName
GO:0001501 skeletal system development
GO:0002020 protease binding
GO:0002063 chondrocyte development
GO:0003417 growth plate cartilage development
GO:0005178 integrin binding
GO:0005201 extracellular matrix structural constituent
GO:0005509 calcium ion binding
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006915 apoptotic process
GO:0006986 response to unfolded protein
GO:0008201 heparin binding
GO:0009306 protein secretion
GO:0009887 animal organ morphogenesis
GO:0010259 multicellular organism aging
GO:0010260 animal organ senescence
GO:0010468 regulation of gene expression
GO:0014829 vascular associated smooth muscle contraction
GO:0016485 protein processing
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0030282 bone mineralization
GO:0030500 regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0031012 extracellular matrix
GO:0032991 protein-containing complex
GO:0035264 multicellular organism growth
GO:0035988 chondrocyte proliferation
GO:0035989 tendon development
GO:0036122 BMP binding
GO:0043066 negative regulation of apoptotic process
GO:0043394 proteoglycan binding
GO:0043395 heparan sulfate proteoglycan binding
GO:0043588 skin development
GO:0048844 artery morphogenesis
GO:0050881 musculoskeletal movement
GO:0050905 neuromuscular process
GO:0060173 limb development
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070527 platelet aggregation
GO:0097084 vascular associated smooth muscle cell development
GO:1900047 negative regulation of hemostasis
GO:1902732 positive regulation of chondrocyte proliferation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR003367 Thrombospondin, type 3-like repeatRepeatRepeat
IPR008859 Thrombospondin, C-terminalDomainDomain
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR017897 Thrombospondin, type 3 repeatRepeatRepeat
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR024665 Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domainDomainDomain
IPR028492 Thrombospondin-5FamilyFamily
IPR028974 TSP type-3 repeatFamilyHomologous superfamily
IPR039081 Thrombospondin-5, coiled coil regionDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01373 CalciumDrugbanksmall molecule