Entity Details

Primary name TSC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49815
EntryNameTSC2_HUMAN
FullNameTuberin
TaxID9606
Evidenceevidence at protein level
Length1807
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesTSC2

GO terms

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GOName
GO:0001843 neural tube closure
GO:0005096 GTPase activator activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006469 negative regulation of protein kinase activity
GO:0006606 protein import into nucleus
GO:0006897 endocytosis
GO:0007507 heart development
GO:0008104 protein localization
GO:0008285 negative regulation of cell population proliferation
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0016239 positive regulation of macroautophagy
GO:0019902 phosphatase binding
GO:0030100 regulation of endocytosis
GO:0030178 negative regulation of Wnt signaling pathway
GO:0031267 small GTPase binding
GO:0032007 negative regulation of TOR signaling
GO:0033596 TSC1-TSC2 complex
GO:0042803 protein homodimerization activity
GO:0043276 anoikis
GO:0043491 protein kinase B signaling
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0050918 positive chemotaxis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051726 regulation of cell cycle
GO:0051879 Hsp90 protein binding
GO:0051898 negative regulation of protein kinase B signaling
GO:1901525 negative regulation of mitophagy

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR000331 Rap/Ran-GAP domainDomainDomain
IPR003913 TuberinFamilyFamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018515 Tuberin-type domainDomainDomain
IPR024584 Tuberin, N-terminalDomainDomain
IPR027107 Tuberin/Ral GTPase-activating protein subunit alphaFamilyFamily
IPR035974 Rap/Ran-GAP superfamilyFamilyHomologous superfamily

Diseases

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Interactions

83 interactions

InteractorPartnerSourcesPublicationsLink
TSC2_HUMAN1433Z_HUMANBioGRID, HPRD, MINT12176984 12364343 12438239 12468542 15161933 16636147 20618440 22001647 details
TSC2_HUMAN1433G_HUMANBioGRID, HPRD, IntAct, MINT12364343 12438239 28514442 28561026 details
TSC2_HUMAN1433S_HUMANHPRD, MINT12364343 12438239 details
TSC2_HUMAN1433E_HUMANBioGRID, HPRD, MINT12438239 17979178 19608861 details
TSC2_HUMAN1433B_HUMANBioGRID, HPRD, IntAct, MINT12176984 12364343 12438239 12468542 12582162 15324660 16636147 17353931 20169078 24255178 28514442 details
TSC2_HUMAN1433F_HUMANHPRD, IntAct, MINT12438239 17979178 28514442 details
TSC2_HUMAN1433T_HUMANBioGRID, HPRD, IntAct, MINT12438239 15161933 17353931 20618440 28514442 details
TSC2_HUMANNEK1_HUMANBioGRID, HPRD, IntAct14690447 details
TSC2_HUMANTSC1_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10585443 10807585 10915759 11175345 11290735 11741832 11741833 12176984 12511557 12869586 14551205 14651849 15340059 15342917 15851026 15851513 15963462 16339216 16424383 16464865 16636147 17077083 17658474 17693255 20166753 20169078 20412061 21134130 25263562 28561026 30514904 9580671 9809973 details
TSC2_HUMANGRB2_HUMANBioGRID, IntAct18624398 details
TSC2_HUMANPIN1_HUMANBioGRID, MINT21900206 details
TSC2_HUMANKITH_HUMANBioGRID, MINT21900206 details
TSC2_HUMANPP1A_HUMANUniProt19389623 details
TSC2_HUMANSGK1_HUMANIntAct27451907 details
TSC2_HUMANTBCD7_HUMANBioGRID, IntAct17658474 26186194 28514442 28561026 details
TSC2_HUMANTRI63_HUMANBioGRID, IntAct31391242 details
TSC2_HUMANTRI55_HUMANBioGRID, IntAct31391242 details
TSC2_HUMANHTRA1_HUMANIntAct21622153 details
TSC2_HUMANRHEB_HUMANBioGRID, HPRD12771962 12820960 12842888 12869586 15854902 17077083 30514904 details
TSC2_HUMANFOXO1_HUMANBioGRID17077083 details
TSC2_HUMANGSK3B_HUMANBioGRID, HPRD12511557 16959574 details
TSC2_HUMANAMD_HUMANBioGRID, HPRD14559897 details
TSC2_HUMANAAPK1_HUMANBioGRID14651849 15261145 28059666 details
TSC2_HUMANFAK1_HUMANBioGRID17043358 details
TSC2_HUMANKS6A1_HUMANBioGRID, HPRD15342917 15757502 details
TSC2_HUMANMK01_HUMANBioGRID, HPRD15342917 15851026 details
TSC2_HUMANUBE3A_HUMANBioGRID15175323 18298802 details
TSC2_HUMANFBXW5_HUMANBioGRID, HPRD18381890 24372178 details
TSC2_HUMANLNX1_HUMANBioGRID22889411 details
TSC2_HUMANCALM1_HUMANBioGRID11811958 15851513 details
TSC2_HUMANCALM2_HUMANBioGRID11811958 15851513 details
TSC2_HUMANCALM3_HUMANBioGRID11811958 15851513 details
TSC2_HUMANESR1_HUMANBioGRID, HPRD15039427 15851513 details
TSC2_HUMANSMAD3_HUMANBioGRID, HPRD15066998 details
TSC2_HUMANMDFI_HUMANBioGRID24722188 details
TSC2_HUMANCBY2_HUMANBioGRID24722188 details
TSC2_HUMANPLK2_HUMANBioGRID20054236 details
TSC2_HUMANPTN11_HUMANBioGRID19299420 details
TSC2_HUMANSPT6H_HUMANBioGRID19299420 details
TSC2_HUMANRABE1_HUMANHPRD9045618 details
TSC2_HUMANFBXL6_HUMANHPRD18381890 details
TSC2_HUMANDAPK1_HUMANBioGRID, MINT21134130 details
TSC2_HUMANSIR1_HUMANBioGRID, UniProt20169165 details
TSC2_HUMANCCND1_HUMANBioGRID, HPRD, IntAct16357142 26977878 details
TSC2_HUMANCDK4_HUMANIntAct26977878 details
TSC2_HUMANCBY1_HUMANBioGRID, IntAct27173435 unassigned1312 details
TSC2_HUMANPICK1_HUMANMINT21653829 details
TSC2_HUMANUSPL1_HUMANMINT21653829 details
TSC2_HUMANSRB4D_HUMANMINT21653829 details
TSC2_HUMANS13A3_HUMANMINT21653829 details
TSC2_HUMANNEUS_HUMANMINT21653829 details
TSC2_HUMANRSSA_HUMANMINT21653829 details
TSC2_HUMANRL4_HUMANMINT21653829 details
TSC2_HUMANPHLB1_HUMANMINT21653829 details
TSC2_HUMANRM21_HUMANMINT21653829 details
TSC2_HUMANMKRN1_HUMANMINT21653829 details
TSC2_HUMANG3P_HUMANMINT21653829 details
TSC2_HUMANANR35_HUMANMINT21653829 details
TSC2_HUMANACTN2_HUMANMINT21653829 details
TSC2_HUMANSEPT4_HUMANMINT21653829 details
TSC2_HUMANRAP1A_HUMANBioGRID12147258 12842888 details
TSC2_HUMANRALA_HUMANBioGRID12842888 details
TSC2_HUMANAKT1_HUMANBioGRID, HPRD12150915 12438239 15342917 details
TSC2_HUMANCAV1_HUMANBioGRID12147258 details
TSC2_HUMANRAB5A_HUMANBioGRID, HPRD12147258 9045618 details
TSC2_HUMANCCND2_HUMANBioGRID16357142 details
TSC2_HUMANCCND3_HUMANBioGRID16357142 details
TSC2_HUMANPLK1_HUMANBioGRID16339216 details
TSC2_HUMANAXIN1_HUMANBioGRID12511557 details
TSC2_HUMANHERC1_HUMANBioGRID16464865 details
TSC2_HUMANCDN1B_HUMANBioGRID, HPRD15355997 17470459 details
TSC2_HUMANSMAD2_HUMANBioGRID, HPRD15066998 details
TSC2_HUMANRRAGA_HUMANBioGRID24529380 25936802 details
TSC2_HUMANRRAGB_HUMANBioGRID24529380 details
TSC2_HUMANRRAGC_HUMANBioGRID24529380 details
TSC2_HUMANRRAGD_HUMANBioGRID24529380 details
TSC2_HUMANCBL_HUMANBioGRID20622121 details
TSC2_HUMANTBK1_HUMANBioGRID28716898 details
TSC2_HUMANMAPK2_HUMANHPRD12582162 details
TSC2_HUMANAKT2_HUMANHPRD12167664 details
TSC2_HUMANAKT3_HUMANHPRD12167664 details
TSC2_HUMANPP2AA_HUMANHPRD17163575 details
TSC2_HUMANMK03_HUMANHPRD15342917 details