Entity Details

Primary name RORG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51449
EntryNameRORG_HUMAN
FullNameNuclear receptor ROR-gamma
TaxID9606
Evidenceevidence at protein level
Length518
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesRORC

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006805 xenobiotic metabolic process
GO:0008142 oxysterol binding
GO:0008270 zinc ion binding
GO:0010906 regulation of glucose metabolic process
GO:0016604 nuclear body
GO:0019218 regulation of steroid metabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0032922 circadian regulation of gene expression
GO:0036315 cellular response to sterol
GO:0042093 T-helper cell differentiation
GO:0042753 positive regulation of circadian rhythm
GO:0045598 regulation of fat cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048535 lymph node development
GO:0048541 Peyer's patch development
GO:0060612 adipose tissue development
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0072539 T-helper 17 cell differentiation
GO:0098531 ligand-activated transcription factor activity
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR003079 Nuclear receptor RORFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily
IPR044101 Retinoid-related orphan receptors, DNA-binding domainDomainDomain

Diseases

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Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
RORG_HUMANEVI2A_HUMANBioGRID, IntAct21988832 details
RORG_HUMANBHE40_HUMANIntAct23555304 details
RORG_HUMANNR1D2_HUMANBioGRID, IntAct23555304 details
RORG_HUMANNPAS2_HUMANBioGRID, IntAct23555304 details
RORG_HUMANPP1G_HUMANBioGRID, IntAct23555304 details
RORG_HUMANPP1A_HUMANBioGRID, IntAct23555304 details
RORG_HUMAN2A5E_HUMANBioGRID, IntAct23555304 details
RORG_HUMAN2A5D_HUMANBioGRID, IntAct23555304 details
RORG_HUMAN2AAB_HUMANBioGRID, IntAct23555304 details
RORG_HUMANRORB_HUMANIntAct23555304 details
RORG_HUMAN2AAA_HUMANBioGRID, IntAct23555304 details
RORG_HUMANBMAL2_HUMANBioGRID, IntAct23555304 details
RORG_HUMANFXL15_HUMANBioGRID, IntAct23555304 details
RORG_HUMANPP1B_HUMANBioGRID, IntAct23555304 details
RORG_HUMANPP2AA_HUMANBioGRID, IntAct23555304 details
RORG_HUMANNCOA1_HUMANIntAct20203100 details
RORG_HUMANPRGC1_HUMANIntAct20203100 details
RORG_HUMANCBP_HUMANIntAct20203100 details
RORG_HUMANPRS8_HUMANBioGRID, IntAct15604093 32296183 details
RORG_HUMANNCOA6_HUMANBioGRID, HPRD15604093 details
RORG_HUMANCIPC_HUMANBioGRID23555304 details
RORG_HUMANKC1E_HUMANBioGRID23555304 details
RORG_HUMANBHE41_HUMANBioGRID23555304 details
RORG_HUMANPER2_HUMANBioGRID23555304 details
RORG_HUMANBMAL1_HUMANBioGRID23555304 details
RORG_HUMANCLOCK_HUMANBioGRID23555304 details
RORG_HUMANCHD4_HUMANHPRD15144897 details
RORG_HUMANFOXP3_HUMANDIP18368049 details
RORG_HUMANUBP4_HUMANBioGRID25821221 details
RORG_HUMANTRAF5_HUMANBioGRID26453305 details
RORG_HUMANEP300_HUMANBioGRID26549310 details
RORG_HUMANHDAC1_HUMANBioGRID26549310 details
RORG_HUMANSRC_HUMANBioGRID27430721 details
RORG_HUMANUBP15_HUMANBioGRID27430721 details
RORG_HUMANCUL4B_HUMANBioGRID30992047 details
RORG_HUMAN4EBP1_HUMANHPRD10405182 details