Entity Details

Primary name STA5B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51692
EntryNameSTA5B_HUMAN
FullNameSignal transducer and activator of transcription 5B
TaxID9606
Evidenceevidence at protein level
Length787
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesSTAT5B

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001553 luteinization
GO:0001779 natural killer cell differentiation
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006952 defense response
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0007565 female pregnancy
GO:0007595 lactation
GO:0019218 regulation of steroid metabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0019530 taurine metabolic process
GO:0019915 lipid storage
GO:0030856 regulation of epithelial cell differentiation
GO:0032355 response to estradiol
GO:0032743 positive regulation of interleukin-2 production
GO:0032819 positive regulation of natural killer cell proliferation
GO:0032825 positive regulation of natural killer cell differentiation
GO:0032870 cellular response to hormone stimulus
GO:0033077 T cell differentiation in thymus
GO:0035259 glucocorticoid receptor binding
GO:0035723 interleukin-15-mediated signaling pathway
GO:0038110 interleukin-2-mediated signaling pathway
GO:0038111 interleukin-7-mediated signaling pathway
GO:0038113 interleukin-9-mediated signaling pathway
GO:0040014 regulation of multicellular organism growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042104 positive regulation of activated T cell proliferation
GO:0042127 regulation of cell population proliferation
GO:0042448 progesterone metabolic process
GO:0042802 identical protein binding
GO:0043029 T cell homeostasis
GO:0043066 negative regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0045579 positive regulation of B cell differentiation
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045647 negative regulation of erythrocyte differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0046543 development of secondary female sexual characteristics
GO:0046544 development of secondary male sexual characteristics
GO:0046983 protein dimerization activity
GO:0048541 Peyer's patch development
GO:0050729 positive regulation of inflammatory response
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0070670 response to interleukin-4
GO:0071363 cellular response to growth factor stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0097531 mast cell migration

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001217 Transcription factor STATFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR012345 STAT transcription factor, DNA-binding, N-terminalFamilyHomologous superfamily
IPR013799 STAT transcription factor, protein interactionDomainDomain
IPR013800 STAT transcription factor, all-alpha domainDomainDomain
IPR013801 STAT transcription factor, DNA-bindingDomainDomain
IPR015988 STAT transcription factor, coiled coilFamilyHomologous superfamily
IPR035858 STAT5a/5bFamilyFamily
IPR035886 STAT5b, SH2 domainDomainDomain
IPR036535 STAT transcription factor, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule

Interactions

72 interactions

InteractorPartnerSourcesPublicationsLink
STA5B_HUMANNMI_HUMANBioGRID, HPRD, IntAct9989503 details
STA5B_HUMANPTN1_HUMANBioGRID, HPRD, MINT12237455 details
STA5B_HUMANIL2RB_HUMANBioGRID, HPRD, MINT10602027 details
STA5B_HUMANINSR_HUMANBioGRID, HPRD, MINT10830280 12456798 9122188 9428692 details
STA5B_HUMANIL15_HUMANBioGRID, IntAct21988832 details
STA5B_HUMANTFG_HUMANBioGRID, IntAct21988832 details
STA5B_HUMANHAX1_HUMANBioGRID, IntAct21988832 details
STA5B_HUMANSRTD1_HUMANBioGRID, IntAct21988832 details
STA5B_HUMANAFTIN_HUMANBioGRID, IntAct21988832 details
STA5B_HUMANDMRTA_HUMANBioGRID, IntAct21988832 details
STA5B_HUMANGHR_HUMANBioGRID, HPRD, IntAct25241761 8923468 details
STA5B_HUMANCTLA4_HUMANBioGRID, HPRD, IntAct16476059 25241761 details
STA5B_HUMANZN410_HUMANIntAct32296183 details
STA5B_HUMANPPL13_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANUBP2_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANCAF1A_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANMED25_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANSTAC_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANP55G_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANTSSK3_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANCDN1A_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANRT06_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANLMO4_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANRBBP4_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANSUOX_HUMANBioGRID, IntAct32296183 details
STA5B_HUMANSTA5B_HUMANBioGRID, HPRD, IntAct12089361 14704793 20962278 22729867 31175292 details
STA5B_HUMANABL1_HUMANIntAct31175292 details
STA5B_HUMANJAK2_HUMANBioGRID, HPRD12538627 24354892 9047382 9575217 details
STA5B_HUMANPTN11_HUMANBioGRID, HPRD10617656 details
STA5B_HUMANJAK1_HUMANBioGRID9047382 details
STA5B_HUMANJAK3_HUMANBioGRID9047382 details
STA5B_HUMANELP2_HUMANBioGRID, HPRD10954736 details
STA5B_HUMANA4_HUMANBioGRID21832049 details
STA5B_HUMANKIT_HUMANBioGRID, HPRD10358045 17554063 details
STA5B_HUMANROA2_HUMANBioGRID32296183 details
STA5B_HUMANNCOR2_HUMANHPRD11726519 details
STA5B_HUMANCENPJ_HUMANHPRD12198240 details
STA5B_HUMANEPOR_HUMANHPRD15644415 8977232 details
STA5B_HUMANSTAP2_HUMANHPRD, MINT15611091 details
STA5B_HUMANEGFR_HUMANBioGRID, HPRD, MINT10558875 11751923 16729043 22729867 details
STA5B_HUMANERBB4_HUMANHPRD, MINT16729043 details
STA5B_HUMANDNJA3_HUMANIntAct21106534 details
STA5B_HUMANSTAT3_HUMANBioGRID, HPRD, IntAct25241761 9398404 details
STA5B_HUMANIL2RA_HUMANHPRD, IntAct10602027 11485747 details
STA5B_HUMANSTA5A_HUMANBioGRID, HPRD, IntAct28514442 9528750 details
STA5B_HUMANEPHA4_HUMANIntAct31413325 details
STA5B_HUMANGCR_HUMANBioGRID, HPRD11158330 8878484 9528750 details
STA5B_HUMANSHC1_HUMANBioGRID, HPRD10996427 details
STA5B_HUMANCD3Z_HUMANBioGRID, HPRD9880255 details
STA5B_HUMANCCR5_HUMANBioGRID11350939 details
STA5B_HUMANPTN6_HUMANBioGRID, HPRD9211920 details
STA5B_HUMANPO2F1_HUMANBioGRID, HPRD14645506 16025120 details
STA5B_HUMANFGFR2_HUMANBioGRID21464042 details
STA5B_HUMANPRGR_HUMANBioGRID21464042 details
STA5B_HUMANPRLR_HUMANBioGRID20962278 details
STA5B_HUMANMK01_HUMANHPRD10996427 details
STA5B_HUMANSRC_HUMANHPRD12621061 details
STA5B_HUMANPTN2_HUMANHPRD11773439 15588985 details
STA5B_HUMANRARA_HUMANHPRD11929748 details
STA5B_HUMANEP300_HUMANHPRD14726487 9989503 details
STA5B_HUMANTIE2_HUMANHPRD14726409 details
STA5B_HUMANCXCR4_HUMANHPRD10506573 details
STA5B_HUMANIL7RA_HUMANHPRD7719938 details
STA5B_HUMANCRK_HUMANHPRD10720694 11097834 9845531 details
STA5B_HUMANCBL_HUMANHPRD12193575 details
STA5B_HUMANPGFRB_HUMANHPRD9484840 details
STA5B_HUMANPGFRA_HUMANHPRD9484840 details
STA5B_HUMANSTAT1_HUMANHPRD10358045 details
STA5B_HUMANCRKL_HUMANHPRD10720694 11097834 9845531 details
STA5B_HUMANPP2AA_HUMANHPRD11440634 details
STA5B_HUMANETS1_HUMANHPRD10815800 details
STA5B_HUMANETS2_HUMANHPRD10815800 details