Entity Details

Primary name PLK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP53350
EntryNamePLK1_HUMAN
FullNameSerine/threonine-protein kinase PLK1
TaxID9606
Evidenceevidence at protein level
Length603
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesPLK1

GO terms

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GOName
GO:0000070 mitotic sister chromatid segregation
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000132 establishment of mitotic spindle orientation
GO:0000278 mitotic cell cycle
GO:0000281 mitotic cytokinesis
GO:0000287 magnesium ion binding
GO:0000776 kinetochore
GO:0000785 chromatin
GO:0000795 synaptonemal complex
GO:0000922 spindle pole
GO:0001578 microtubule bundle formation
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005819 spindle
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007052 mitotic spindle organization
GO:0007062 sister chromatid cohesion
GO:0007076 mitotic chromosome condensation
GO:0007077 mitotic nuclear membrane disassembly
GO:0007094 mitotic spindle assembly checkpoint signaling
GO:0007098 centrosome cycle
GO:0007346 regulation of mitotic cell cycle
GO:0008017 microtubule binding
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010997 anaphase-promoting complex binding
GO:0015630 microtubule cytoskeleton
GO:0016321 female meiosis chromosome segregation
GO:0016567 protein ubiquitination
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0030071 regulation of mitotic metaphase/anaphase transition
GO:0030496 midbody
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031648 protein destabilization
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032465 regulation of cytokinesis
GO:0034451 centriolar satellite
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043393 regulation of protein binding
GO:0045143 homologous chromosome segregation
GO:0045184 establishment of protein localization
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045862 positive regulation of proteolysis
GO:0051081 nuclear membrane disassembly
GO:0051233 spindle midzone
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0051726 regulation of cell cycle
GO:0070194 synaptonemal complex disassembly
GO:0071168 protein localization to chromatin
GO:0090435 protein localization to nuclear envelope
GO:0097431 mitotic spindle pole
GO:0097711 ciliary basal body-plasma membrane docking
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900182 positive regulation of protein localization to nucleus
GO:1901673 regulation of mitotic spindle assembly
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902749 regulation of cell cycle G2/M phase transition
GO:1904668 positive regulation of ubiquitin protein ligase activity
GO:1904776 regulation of protein localization to cell cortex

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Midbody
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000959 POLO box domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR033695 Second polo-box domainDomainDomain
IPR033701 First polo-box domainDomainDomain
IPR033702 Polo-like kinase 1, catalytic domainDomainDomain
IPR036947 POLO box domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB06897 3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-olDrugbanksmall molecule
DB06963 3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamideDrugbanksmall molecule
DB07186 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDEDrugbanksmall molecule
DB07789 1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]ureaDrugbanksmall molecule
DB08059 WortmanninDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

222 interactions

InteractorPartnerSourcesPublicationsLink
PLK1_HUMANMPIP3_HUMANBioGRID, DIP, HPRD, MINT11202906 11897663 12595692 14532005 16753148 17307877 19503101 19597481 details
PLK1_HUMANPLK1_HUMANDIP, MINT14532005 21041660 23354166 26192437 details
PLK1_HUMANMCM7_HUMANBioGRID, HPRD, IntAct15654075 details
PLK1_HUMANDNJB9_HUMANBioGRID, HPRD, IntAct16169070 details
PLK1_HUMANGET4_HUMANBioGRID, HPRD, IntAct16169070 details
PLK1_HUMANMAGD1_HUMANBioGRID, HPRD, IntAct16169070 details
PLK1_HUMANRECQ5_HUMANBioGRID, HPRD, IntAct16169070 details
PLK1_HUMANFBX5_HUMANBioGRID, IntAct15469984 16439210 details
PLK1_HUMANWEE1_HUMANBioGRID, HPRD, IntAct15070733 25659891 details
PLK1_HUMANP53_HUMANBioGRID, HPRD, MINT15024021 16753148 19833129 22653443 details
PLK1_HUMANCHK2_HUMANBioGRID, DIP, HPRD, IntAct10973490 11901158 12024051 12242661 12493754 20126263 details
PLK1_HUMANMYC_HUMANBioGRID, IntAct17314511 27773673 29467282 30415952 details
PLK1_HUMANSLX4_HUMANBioGRID, IntAct19596235 22902628 25659891 25852190 31495888 details
PLK1_HUMANMDM2_HUMANBioGRID, MINT19833129 details
PLK1_HUMANGTSE1_HUMANMINT20577264 details
PLK1_HUMANSTK3_HUMANBioGRID, IntAct20562859 24255178 27566175 details
PLK1_HUMANFADD_HUMANI2D20890306 details
PLK1_HUMANTANK_HUMANBioGRID, IntAct20484576 21988832 details
PLK1_HUMANEP300_HUMANIntAct21988832 details
PLK1_HUMANPHC2_HUMANBioGRID, IntAct21988832 details
PLK1_HUMANOFD1_HUMANBioGRID, IntAct21988832 26638075 details
PLK1_HUMANPRAF1_HUMANBioGRID, IntAct21988832 details
PLK1_HUMANKRBA1_HUMANBioGRID, IntAct21988832 details
PLK1_HUMANNEK9_HUMANMINT21642957 details
PLK1_HUMANMK06_HUMANBioGRID, IntAct, MINT21900206 26972000 29426014 details
PLK1_HUMANACL6B_HUMANBioGRID, MINT21900206 details
PLK1_HUMANCREL2_HUMANMINT21900206 details
PLK1_HUMANSIMC1_HUMANBioGRID, MINT21900206 details
PLK1_HUMANCF136_HUMANBioGRID, MINT21900206 details
PLK1_HUMANCI114_HUMANBioGRID, MINT21900206 details
PLK1_HUMANCC115_HUMANBioGRID, MINT21900206 details
PLK1_HUMANCIC_HUMANBioGRID, MINT21900206 29844126 details
PLK1_HUMANINT11_HUMANBioGRID, MINT21900206 details
PLK1_HUMANIF6_HUMANBioGRID, MINT21900206 details
PLK1_HUMANFBXL5_HUMANBioGRID, MINT21900206 details
PLK1_HUMANBGAL_HUMANBioGRID, MINT21900206 details
PLK1_HUMANITSN1_HUMANBioGRID, MINT21900206 details
PLK1_HUMANLMO4_HUMANBioGRID, MINT21900206 details
PLK1_HUMANLRP5L_HUMANBioGRID, MINT21900206 details
PLK1_HUMANMPP2_HUMANBioGRID, MINT21900206 details
PLK1_HUMANPPID_HUMANBioGRID, MINT21900206 details
PLK1_HUMANRN126_HUMANBioGRID, MINT21900206 details
PLK1_HUMANRXRA_HUMANBioGRID, MINT21900206 details
PLK1_HUMANASPP2_HUMANBioGRID, MINT21900206 details
PLK1_HUMANVRK3_HUMANBioGRID, MINT21900206 details
PLK1_HUMANZNF71_HUMANBioGRID, MINT21900206 details
PLK1_HUMANTNF11_HUMANBioGRID, MINT21900206 details
PLK1_HUMANRD23B_HUMANIntAct21887822 details
PLK1_HUMANIF4B_HUMANIntAct21887822 details
PLK1_HUMANHS71A_HUMANIntAct21887822 details
PLK1_HUMANHS71B_HUMANIntAct21887822 details
PLK1_HUMANCASL_HUMANMINT22609948 details
PLK1_HUMANLRRK2_HUMANBioGRID, IntAct24510904 details
PLK1_HUMANNINL_HUMANBioGRID, HPRD, IntAct12852856 26638075 28718761 details
PLK1_HUMANHSF1_HUMANBioGRID, IntAct18794143 27173435 unassigned1312 details
PLK1_HUMANNHSL2_HUMANBioGRID, IntAct32296183 details
PLK1_HUMANMAVS_HUMANBioGRID, IntAct28514442 30267576 32877691 details
PLK1_HUMANCENPU_HUMANBioGRID, DIP, IntAct19597481 21454580 28514442 details
PLK1_HUMANPTPRD_HUMANBioGRID, MINT22305495 details
PLK1_HUMANKAT7_HUMANDIP18250300 details
PLK1_HUMANAURKA_HUMANBioGRID, DIP18615013 18773538 22939629 details
PLK1_HUMANRGAP1_HUMANBioGRID, DIP19468300 19468302 25486482 details
PLK1_HUMANPLK2_HUMANDIP19706541 details
PLK1_HUMANTP53B_HUMANBioGRID, DIP20126263 25607646 25659891 details
PLK1_HUMANCDC6_HUMANDIP21041660 details
PLK1_HUMANCEP68_HUMANDIP25503564 details
PLK1_HUMANLRRK1_HUMANBioGRID, DIP26192437 29513927 details
PLK1_HUMANMEIKN_HUMANDIP25533956 details
PLK1_HUMANCASP8_HUMANIntAct32814053 details
PLK1_HUMANPSN1_HUMANIntAct32814053 details
PLK1_HUMANTGIF1_HUMANIntAct32814053 details
PLK1_HUMANA4_HUMANBioGRID, IntAct21244100 21832049 32814053 details
PLK1_HUMANBRCA2_HUMANBioGRID, HPRD12815053 14647413 24448238 24835992 28985013 details
PLK1_HUMANNUDC_HUMANBioGRID, HPRD12852857 details
PLK1_HUMANPIN1_HUMANBioGRID, HPRD10037602 16118204 9499405 details
PLK1_HUMANPSA3_HUMANBioGRID, HPRD11205743 details
PLK1_HUMANPSA4_HUMANBioGRID, HPRD11205743 details
PLK1_HUMANCHFR_HUMANBioGRID11807090 19182791 details
PLK1_HUMANTOPRS_HUMANBioGRID19473992 19821153 22972498 details
PLK1_HUMANTF65_HUMANBioGRID21610149 details
PLK1_HUMANBAG6_HUMANBioGRID21900206 details
PLK1_HUMANTBB3_HUMANBioGRID10191277 details
PLK1_HUMANNEDD4_HUMANBioGRID19953087 25047839 details
PLK1_HUMANDNHD1_HUMANBioGRID21507953 details
PLK1_HUMANCENPQ_HUMANBioGRID21454580 details
PLK1_HUMANCASB_HUMANBioGRID21454580 7790358 details
PLK1_HUMANIKKB_HUMANBioGRID18957422 details
PLK1_HUMANTARA_HUMANBioGRID22820163 details
PLK1_HUMANBUB1B_HUMANBioGRID17376779 19503101 23455478 24067371 26323689 28410192 details
PLK1_HUMANCASA1_HUMANBioGRID7790358 details
PLK1_HUMANBUB1_HUMANBioGRID, HPRD16760428 details
PLK1_HUMANSTAG2_HUMANBioGRID15737063 details
PLK1_HUMANSYUA_HUMANBioGRID19889641 details
PLK1_HUMANSYUB_HUMANBioGRID19889641 details
PLK1_HUMANCDC20_HUMANBioGRID23160376 23643811 25659891 26912231 details
PLK1_HUMANKLH22_HUMANBioGRID23455478 24067371 details
PLK1_HUMANSGT1_HUMANBioGRID22869522 details
PLK1_HUMANFZR1_HUMANBioGRID21700221 23160376 23972993 26387737 details
PLK1_HUMANRPGP1_HUMANBioGRID25329897 details
PLK1_HUMANCC14A_HUMANBioGRID19390576 details
PLK1_HUMANKIF2C_HUMANBioGRID24931513 details
PLK1_HUMANREST_HUMANBioGRID25453754 details
PLK1_HUMANFOXO3_HUMANBioGRID25659891 26280018 details
PLK1_HUMANUBP16_HUMANBioGRID26323689 details
PLK1_HUMANPRKN_HUMANBioGRID26387737 details
PLK1_HUMANRICTR_HUMANBioGRID25714006 details
PLK1_HUMANMAPK2_HUMANBioGRID18695677 details
PLK1_HUMANTOP2A_HUMANBioGRID18695677 details
PLK1_HUMANFBXW7_HUMANBioGRID27773673 details
PLK1_HUMANPTEN_HUMANBioGRID25047839 details
PLK1_HUMANRGCC_HUMANBioGRID17146433 details
PLK1_HUMANSRBP1_HUMANBioGRID27579997 details
PLK1_HUMANB2CL1_HUMANBioGRID22617334 details
PLK1_HUMANCHIP_HUMANBioGRID27390342 details
PLK1_HUMANPLK3_HUMANBioGRID12548019 details
PLK1_HUMANRING2_HUMANBioGRID29565459 details
PLK1_HUMANP73_HUMANBioGRID18174154 details
PLK1_HUMANRAD51_HUMANBioGRID22325354 24835992 details
PLK1_HUMANMD2BP_HUMANBioGRID31118282 details
PLK1_HUMANTPT1L_HUMANBioGRID32296183 details
PLK1_HUMANKLF4_HUMANBioGRID31281496 details
PLK1_HUMANUBP7_HUMANBioGRID31730000 details
PLK1_HUMANPAR10_HUMANBioGRID32060423 details
PLK1_HUMANGORS1_HUMANHPRD11447294 details
PLK1_HUMANMCM2_HUMANBioGRID, HPRD, IntAct15654075 27173435 unassigned1312 details
PLK1_HUMANMCM3_HUMANBioGRID, HPRD, IntAct15654075 details
PLK1_HUMANEVI5_HUMANBioGRID, IntAct16439210 26496610 details
PLK1_HUMANRGRF1_HUMANMINT16753148 details
PLK1_HUMANBIRC6_HUMANBioGRID, HPRD, IntAct18329369 26496610 details
PLK1_HUMANJIP4_HUMANBioGRID, IntAct19596235 25659891 27173435 28514442 unassigned1312 details
PLK1_HUMANBORA_HUMANBioGRID, DIP, IntAct18378770 18615013 19596235 24067368 25659891 26186194 28514442 details
PLK1_HUMANXPF_HUMANBioGRID, IntAct19596235 25659891 28514442 details
PLK1_HUMANERC6L_HUMANBioGRID, IntAct19596235 20360068 25659891 26496610 28514442 details
PLK1_HUMANPAK1_HUMANMINT20869364 details
PLK1_HUMANPAK3_HUMANMINT20869364 details
PLK1_HUMANCLIP1_HUMANMINT20664522 details
PLK1_HUMANDVL2_HUMANBioGRID, MINT22609948 25659891 31340145 details
PLK1_HUMANPMYT1_HUMANHPRD, IntAct12738781 23397142 details
PLK1_HUMANCCNB1_HUMANHPRD, IntAct11242082 23397142 details
PLK1_HUMANINCE_HUMANIntAct21051298 details
PLK1_HUMANADIP_HUMANMINT24397932 details
PLK1_HUMANEP15R_HUMANBioGRID, IntAct26496610 27173435 unassigned1312 details
PLK1_HUMANFOXJ1_HUMANBioGRID, IntAct27173435 unassigned1312 details
PLK1_HUMANIFT43_HUMANBioGRID, IntAct27173435 unassigned1312 details
PLK1_HUMANUBP15_HUMANBioGRID, IntAct27173435 unassigned1312 details
PLK1_HUMANDCAF7_HUMANBioGRID, IntAct27173435 unassigned1312 details
PLK1_HUMANCFA20_HUMANBioGRID, IntAct27173435 unassigned1312 details
PLK1_HUMANNS1BP_HUMANBioGRID, IntAct27173435 unassigned1312 details
PLK1_HUMANSMC1A_HUMANBioGRID, IntAct26344197 27173435 unassigned1312 details
PLK1_HUMANMED1_HUMANBioGRID, IntAct27173435 unassigned1312 details
PLK1_HUMANTF3C5_HUMANBioGRID, IntAct25659891 27173435 unassigned1312 details
PLK1_HUMANTF3C4_HUMANBioGRID, IntAct27173435 unassigned1312 details
PLK1_HUMANSF3B3_HUMANBioGRID, IntAct27173435 unassigned1312 details
PLK1_HUMANHDAC2_HUMANBioGRID, IntAct27173435 unassigned1312 details
PLK1_HUMANMCM6_HUMANBioGRID, IntAct15654075 27173435 31730000 unassigned1312 details
PLK1_HUMANMCM4_HUMANBioGRID, IntAct15654075 27173435 31730000 unassigned1312 details
PLK1_HUMANSPAG5_HUMANBioGRID, IntAct25659891 27173435 unassigned1312 details
PLK1_HUMANRFX3_HUMANBioGRID, IntAct27173435 unassigned1312 details
PLK1_HUMANNEK7_HUMANBioGRID, IntAct27173435 unassigned1312 details
PLK1_HUMANTOPB1_HUMANBioGRID, IntAct26186194 26811421 28514442 details
PLK1_HUMANAXIN2_HUMANDIP16815967 details
PLK1_HUMANBLM_HUMANDIP16864798 details
PLK1_HUMANPRC1_HUMANBioGRID, DIP, HPRD17351640 19468300 31586073 details
PLK1_HUMANFBW1A_HUMANDIP25503564 details
PLK1_HUMANBRCA1_HUMANBioGRID, UniProt24067368 25483079 29656893 31730000 details
PLK1_HUMANDCTN1_HUMANBioGRID12852857 34079125 details
PLK1_HUMANTSC1_HUMANBioGRID, HPRD16339216 details
PLK1_HUMANTSC2_HUMANBioGRID16339216 details
PLK1_HUMANPSA7_HUMANBioGRID, HPRD11205743 details
PLK1_HUMANPSA5_HUMANBioGRID, HPRD11205743 details
PLK1_HUMANPSA2_HUMANBioGRID11205743 details
PLK1_HUMANPSA6_HUMANBioGRID, HPRD11205743 details
PLK1_HUMANPSB1_HUMANBioGRID, HPRD11205743 details
PLK1_HUMANPSB3_HUMANBioGRID, HPRD11205743 details
PLK1_HUMANPSA1_HUMANBioGRID, HPRD11205743 details
PLK1_HUMANPSB5_HUMANBioGRID, HPRD11205743 details
PLK1_HUMANPSB6_HUMANBioGRID, HPRD11205743 details
PLK1_HUMANPSB7_HUMANBioGRID, HPRD11205743 details
PLK1_HUMANSGO1_HUMANBioGRID18331714 details
PLK1_HUMANCYLD_HUMANBioGRID17495026 details
PLK1_HUMANCLSPN_HUMANBioGRID16885021 16885022 25659891 details
PLK1_HUMANCTBP1_HUMANBioGRID16481748 details
PLK1_HUMANNEMO_HUMANBioGRID20484576 details
PLK1_HUMANCTNB1_HUMANBioGRID, HPRD19001871 21610149 details
PLK1_HUMANTBA1A_HUMANBioGRID10191277 details
PLK1_HUMANTBG1_HUMANBioGRID, HPRD10191277 details
PLK1_HUMANCALL5_HUMANBioGRID16934469 details
PLK1_HUMANPTN14_HUMANBioGRID22948661 27432908 details
PLK1_HUMANUBP37_HUMANBioGRID23027877 details
PLK1_HUMANTERA_HUMANBioGRID23383273 32728610 details
PLK1_HUMANHSP74_HUMANBioGRID21887822 details
PLK1_HUMANKLH21_HUMANBioGRID23455478 details
PLK1_HUMANKLHL9_HUMANBioGRID23455478 details
PLK1_HUMANCUL2_HUMANBioGRID23455478 details
PLK1_HUMANLATS1_HUMANBioGRID22641346 details
PLK1_HUMANCDCA5_HUMANBioGRID21987589 details
PLK1_HUMANMUS81_HUMANBioGRID21962513 details
PLK1_HUMANNUAK1_HUMANBioGRID24785407 details
PLK1_HUMANMTMR3_HUMANBioGRID25659891 27432908 27880917 details
PLK1_HUMANJADE1_HUMANBioGRID26919559 details
PLK1_HUMANFOXM1_HUMANBioGRID27542221 details
PLK1_HUMANRAE1L_HUMANBioGRID29293652 details
PLK1_HUMANUBP11_HUMANBioGRID29293652 details
PLK1_HUMANSORCN_HUMANBioGRID24427308 details
PLK1_HUMANMCM5_HUMANBioGRID15654075 details
PLK1_HUMANMTMR4_HUMANBioGRID25659891 28675297 details
PLK1_HUMANKIF23_HUMANBioGRID, HPRD31730000 8524282 details
PLK1_HUMANBIN1_HUMANBioGRID31815296 details
PLK1_HUMANCUL3_HUMANBioGRID31815296 details
PLK1_HUMANTRIM8_HUMANBioGRID31904480 details
PLK1_HUMANCRBN_HUMANBioGRID32728610 details
PLK1_HUMANCEP55_HUMANHPRD16198290 details
PLK1_HUMANTBA4A_HUMANHPRD10191277 details
PLK1_HUMANTBB2A_HUMANHPRD10191277 details
PLK1_HUMANMYT1_HUMANHPRD12738781 details
PLK1_HUMANPSB2_HUMANHPRD11205743 details
PLK1_HUMANPSB4_HUMANHPRD11205743 details
PLK1_HUMANASPM_HUMANHPRD11283617 details
PLK1_HUMANTCTP_HUMANHPRD12167714 details
PLK1_HUMANPITM1_HUMANHPRD15125835 details
PLK1_HUMANECT2_HUMANHPRD16247472 details
PLK1_HUMANNPM_HUMANHPRD15190079 details