Entity Details

Primary name PAR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP55085
EntryNamePAR2_HUMAN
FullNameProteinase-activated receptor 2
TaxID9606
Evidenceevidence at protein level
Length397
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesF2RL1

GO terms

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GOName
GO:0001965 G-protein alpha-subunit binding
GO:0002286 T cell activation involved in immune response
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0003104 positive regulation of glomerular filtration
GO:0004930 G protein-coupled receptor activity
GO:0005102 signaling receptor binding
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007596 blood coagulation
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015057 thrombin-activated receptor activity
GO:0030193 regulation of blood coagulation
GO:0030335 positive regulation of cell migration
GO:0030836 positive regulation of actin filament depolymerization
GO:0031143 pseudopodium
GO:0031274 positive regulation of pseudopodium assembly
GO:0031681 G-protein beta-subunit binding
GO:0032682 negative regulation of chemokine production
GO:0032722 positive regulation of chemokine production
GO:0032729 positive regulation of interferon-gamma production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032733 positive regulation of interleukin-10 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032930 positive regulation of superoxide anion generation
GO:0034137 positive regulation of toll-like receptor 2 signaling pathway
GO:0034140 negative regulation of toll-like receptor 3 signaling pathway
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0035025 positive regulation of Rho protein signal transduction
GO:0038023 signaling receptor activity
GO:0042119 neutrophil activation
GO:0042311 vasodilation
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043311 positive regulation of eosinophil degranulation
GO:0043547 positive regulation of GTPase activity
GO:0045087 innate immune response
GO:0045217 cell-cell junction maintenance
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046328 regulation of JNK cascade
GO:0046329 negative regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0050900 leukocyte migration
GO:0050921 positive regulation of chemotaxis
GO:0050927 positive regulation of positive chemotaxis
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
GO:0051607 defense response to virus
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0061028 establishment of endothelial barrier
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070661 leukocyte proliferation
GO:0070963 positive regulation of neutrophil mediated killing of gram-negative bacterium
GO:0097029 mature conventional dendritic cell differentiation
GO:1900135 positive regulation of renin secretion into blood stream
GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR002281 Protease-activated receptor 2FamilyFamily
IPR003912 Protease-activated receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Interactions

83 interactions

InteractorPartnerSourcesPublicationsLink
PAR2_HUMANCSN5_HUMANBioGRID, HPRD, UniProt16410250 details
PAR2_HUMANTMED2_HUMANUniProt17693410 21219331 details
PAR2_HUMANHS71B_HUMANBioGRID, MINT28298427 details
PAR2_HUMANAT2A2_HUMANBioGRID, MINT28298427 details
PAR2_HUMANPRIO_HUMANBioGRID, MINT28298427 details
PAR2_HUMANABHEA_HUMANBioGRID, MINT28298427 details
PAR2_HUMANADCY2_HUMANBioGRID, MINT28298427 details
PAR2_HUMANAR6P1_HUMANBioGRID, MINT28298427 details
PAR2_HUMANABCC8_HUMANBioGRID, MINT28298427 details
PAR2_HUMANAT2B1_HUMANBioGRID, MINT28298427 details
PAR2_HUMANAT2C1_HUMANBioGRID, MINT28298427 details
PAR2_HUMANBASI_HUMANBioGRID, MINT28298427 details
PAR2_HUMANCALX_HUMANBioGRID, MINT28298427 details
PAR2_HUMANCNN3_HUMANBioGRID, MINT28298427 details
PAR2_HUMANCRLS1_HUMANBioGRID, MINT28298427 details
PAR2_HUMANCTNA1_HUMANBioGRID, MINT28298427 details
PAR2_HUMANCD63_HUMANBioGRID, MINT28298427 details
PAR2_HUMANCD81_HUMANBioGRID, MINT28298427 details
PAR2_HUMANMORN4_HUMANBioGRID, MINT28298427 details
PAR2_HUMANS18B1_HUMANBioGRID, MINT28298427 details
PAR2_HUMANCPNS1_HUMANBioGRID, MINT28298427 details
PAR2_HUMANNAT14_HUMANBioGRID, MINT28298427 details
PAR2_HUMANHLAE_HUMANBioGRID, MINT28298427 details
PAR2_HUMANKLC1_HUMANBioGRID, MINT28298427 details
PAR2_HUMANERD21_HUMANBioGRID, MINT28298427 details
PAR2_HUMANICAM2_HUMANBioGRID, MINT28298427 details
PAR2_HUMANP4HTM_HUMANBioGRID, MINT28298427 details
PAR2_HUMANHERP1_HUMANBioGRID, MINT28298427 details
PAR2_HUMANHMOX2_HUMANBioGRID, MINT28298427 details
PAR2_HUMANQSER1_HUMANBioGRID, MINT28298427 details
PAR2_HUMANCXG2_HUMANBioGRID, MINT28298427 details
PAR2_HUMANCXB6_HUMANBioGRID, MINT28298427 details
PAR2_HUMANERGI3_HUMANBioGRID, MINT28298427 details
PAR2_HUMANOSTC_HUMANBioGRID, MINT28298427 details
PAR2_HUMANCLPT1_HUMANBioGRID, MINT28298427 details
PAR2_HUMANVIAAT_HUMANBioGRID, MINT28298427 details
PAR2_HUMANNBPFF_HUMANBioGRID, MINT28298427 details
PAR2_HUMANS12A5_HUMANBioGRID, MINT28298427 details
PAR2_HUMANSATT_HUMANBioGRID, MINT28298427 details
PAR2_HUMANSCN1B_HUMANBioGRID, MINT28298427 details
PAR2_HUMANRGR_HUMANBioGRID, MINT28298427 details
PAR2_HUMANRTN4_HUMANBioGRID, MINT28298427 details
PAR2_HUMANRTN1_HUMANBioGRID, MINT28298427 details
PAR2_HUMANR3HD1_HUMANBioGRID, MINT28298427 details
PAR2_HUMANPRS6A_HUMANBioGRID, MINT28298427 details
PAR2_HUMANPRRT2_HUMANBioGRID, MINT28298427 details
PAR2_HUMANPHLA1_HUMANBioGRID, MINT28298427 details
PAR2_HUMANPTSS2_HUMANBioGRID, MINT28298427 details
PAR2_HUMANPIGU_HUMANBioGRID, MINT28298427 details
PAR2_HUMANCOPT2_HUMANBioGRID, MINT28298427 details
PAR2_HUMANS39AD_HUMANBioGRID, MINT28298427 details
PAR2_HUMANLAT4_HUMANBioGRID, MINT28298427 details
PAR2_HUMANDHSD_HUMANBioGRID, MINT28298427 details
PAR2_HUMANSNG2_HUMANBioGRID, MINT28298427 details
PAR2_HUMANMFS10_HUMANBioGRID, MINT28298427 details
PAR2_HUMANS35A1_HUMANBioGRID, MINT28298427 details
PAR2_HUMANLFG3_HUMANBioGRID, MINT28298427 details
PAR2_HUMANTMED1_HUMANBioGRID, MINT28298427 details
PAR2_HUMANT161A_HUMANBioGRID, MINT28298427 details
PAR2_HUMANTMM62_HUMANBioGRID, MINT28298427 details
PAR2_HUMANWFS1_HUMANBioGRID, MINT28298427 details
PAR2_HUMANTMX2_HUMANBioGRID, MINT28298427 details
PAR2_HUMANPPM1J_HUMANBioGRID, MINT28298427 details
PAR2_HUMANYIPF6_HUMANBioGRID, MINT28298427 details
PAR2_HUMANYIPF1_HUMANBioGRID, MINT28298427 details
PAR2_HUMANDNM3L_HUMANBioGRID24952347 details
PAR2_HUMANLMNA_HUMANBioGRID24623722 details
PAR2_HUMANHS71A_HUMANBioGRID28298427 details
PAR2_HUMANAPRIO_HUMANBioGRID28298427 details
PAR2_HUMANCBL_HUMANHPRD, UniProt15708858 details
PAR2_HUMANTLR4_HUMANUniProt18622013 details
PAR2_HUMANTMEDA_HUMANUniProt21219331 details
PAR2_HUMANTF_HUMANDIP16959886 details
PAR2_HUMANBIRC5_HUMANBioGRID20826780 details
PAR2_HUMANPLMN_HUMANHPRD10978167 12604689 9020112 details
PAR2_HUMANPRTN3_HUMANHPRD10978167 details
PAR2_HUMANST14_HUMANHPRD10831593 details
PAR2_HUMANCATG_HUMANHPRD10978167 details
PAR2_HUMANTHRB_HUMANHPRD10978167 details
PAR2_HUMANELNE_HUMANHPRD10978167 details
PAR2_HUMANCAN1_HUMANHPRD10978167 details
PAR2_HUMANCAN2_HUMANHPRD10978167 details
PAR2_HUMANGASP1_HUMANHPRD15452121 details