Entity Details

Primary name CAV3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP56539
EntryNameCAV3_HUMAN
FullNameCaveolin-3
TaxID9606
Evidenceevidence at protein level
Length151
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesCAV3

GO terms

Show/Hide Table
GOName
GO:0000139 Golgi membrane
GO:0001778 plasma membrane repair
GO:0002027 regulation of heart rate
GO:0005246 calcium channel regulator activity
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0006469 negative regulation of protein kinase activity
GO:0006641 triglyceride metabolic process
GO:0006897 endocytosis
GO:0006936 muscle contraction
GO:0007009 plasma membrane organization
GO:0007015 actin filament organization
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007517 muscle organ development
GO:0007520 myoblast fusion
GO:0008016 regulation of heart contraction
GO:0008022 protein C-terminus binding
GO:0008104 protein localization
GO:0008284 positive regulation of cell population proliferation
GO:0009986 cell surface
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0010831 positive regulation of myotube differentiation
GO:0014704 intercalated disc
GO:0014819 regulation of skeletal muscle contraction
GO:0016010 dystrophin-associated glycoprotein complex
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0017080 sodium channel regulator activity
GO:0019870 potassium channel inhibitor activity
GO:0030018 Z disc
GO:0030154 cell differentiation
GO:0030315 T-tubule
GO:0031116 positive regulation of microtubule polymerization
GO:0031122 cytoplasmic microtubule organization
GO:0031579 membrane raft organization
GO:0031594 neuromuscular junction
GO:0031982 vesicle
GO:0033292 T-tubule organization
GO:0035995 detection of muscle stretch
GO:0038009 regulation of signal transduction by receptor internalization
GO:0042383 sarcolemma
GO:0042391 regulation of membrane potential
GO:0042593 glucose homeostasis
GO:0042632 cholesterol homeostasis
GO:0043014 alpha-tubulin binding
GO:0043231 intracellular membrane-bounded organelle
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0044325 transmembrane transporter binding
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045792 negative regulation of cell size
GO:0046716 muscle cell cellular homeostasis
GO:0050998 nitric-oxide synthase binding
GO:0051001 negative regulation of nitric-oxide synthase activity
GO:0051394 regulation of nerve growth factor receptor activity
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051647 nucleus localization
GO:0051896 regulation of protein kinase B signaling
GO:0051926 negative regulation of calcium ion transport
GO:0055013 cardiac muscle cell development
GO:0055117 regulation of cardiac muscle contraction
GO:0060090 molecular adaptor activity
GO:0060299 negative regulation of sarcomere organization
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060347 heart trabecula formation
GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization
GO:0060762 regulation of branching involved in mammary gland duct morphogenesis
GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
GO:0070836 caveola assembly
GO:0071253 connexin binding
GO:0071417 cellular response to organonitrogen compound
GO:0072659 protein localization to plasma membrane
GO:0086005 ventricular cardiac muscle cell action potential
GO:0090279 regulation of calcium ion import
GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction
GO:1900744 regulation of p38MAPK cascade
GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential
GO:1900826 negative regulation of membrane depolarization during cardiac muscle cell action potential
GO:1901017 negative regulation of potassium ion transmembrane transporter activity
GO:1901019 regulation of calcium ion transmembrane transporter activity
GO:1901380 negative regulation of potassium ion transmembrane transport
GO:2000009 negative regulation of protein localization to cell surface
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2000649 regulation of sodium ion transmembrane transporter activity
GO:2001288 positive regulation of caveolin-mediated endocytosis

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Golgi apparatus membrane
Membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR001612 CaveolinFamilyFamily
IPR018361 Caveolin, conserved siteSiteConserved site
IPR031091 Caveolin-3FamilyFamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
123320 OMIMHyperCKmia (HYPCK)Characterized by persistent elevated levels of serum creatine kinase without muscle weakness. The disease is caused by variants affecting the gene represented in this entry.
192600 OMIMCardiomyopathy, familial hypertrophic 1 (CMH1)A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. The disease is caused by variants affecting the gene represented in this entry.
611818 OMIMLong QT syndrome 9 (LQT9)A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. The disease is caused by variants affecting the gene represented in this entry.
606072 OMIMRippling muscle disease 2 (RMD2)A disorder characterized by mechanically triggered contractions of skeletal muscle. Mechanical stimulation leads to electrically silent muscle contractions that spread to neighboring fibers and cause visible ripples to move over the muscle. RMD2 inheritance is autosomal dominant or autosomal recessive. The disease is caused by variants affecting the gene represented in this entry.
614321 OMIMMyopathy, distal, Tateyama type (MPDT)A disorder characterized by progressive muscular atrophy and muscle weakness beginning in the hands, the legs, or the feet. Muscle atrophy may be restricted to the small muscles of the hands and feet. The disease is caused by variants affecting the gene represented in this entry.
272120 OMIMSudden infant death syndrome (SIDS)SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
CAV3_HUMANPCBP1_HUMANBioGRID, IntAct21988832 details
CAV3_HUMANTEBP_HUMANBioGRID, IntAct21988832 details
CAV3_HUMANRBFA_HUMANBioGRID, IntAct32296183 details
CAV3_HUMANADRB2_HUMANBioGRID, MINT21362625 28298427 details
CAV3_HUMANDAG1_HUMANBioGRID, HPRD10988290 details
CAV3_HUMANPGFRB_HUMANBioGRID10066366 details
CAV3_HUMANPGFRA_HUMANBioGRID10066366 details
CAV3_HUMANEGFR_HUMANBioGRID, HPRD9374534 details
CAV3_HUMANSENP1_HUMANBioGRID21362625 details
CAV3_HUMANRYR1_HUMANBioGRID23071107 details
CAV3_HUMANPBX3_HUMANBioGRID32296183 details
CAV3_HUMANKCJ12_HUMANBioGRID29326130 details
CAV3_HUMANCAVN3_HUMANMINT19262564 details
CAV3_HUMANCAVN1_HUMANBioGRID, IntAct19726876 28514442 details
CAV3_HUMANJPH2_HUMANBioGRID, HPRD15541368 details
CAV3_HUMANNAC1_HUMANBioGRID, HPRD11821059 details
CAV3_HUMANPFKAM_HUMANBioGRID, HPRD9252390 details
CAV3_HUMANDYSF_HUMANBioGRID, HPRD11532985 details
CAV3_HUMANKCNH2_HUMANBioGRID22879586 details
CAV3_HUMANNED4L_HUMANBioGRID22879586 details
CAV3_HUMANSCN5A_HUMANBioGRID17060380 details
CAV3_HUMANKCMA1_HUMANBioGRID15703204 details
CAV3_HUMANTRI72_HUMANBioGRID27810898 details
CAV3_HUMANKCNJ4_HUMANBioGRID29326130 details
CAV3_HUMANKCNJ2_HUMANBioGRID29326130 details
CAV3_HUMANINSR_HUMANHPRD9756945 details
CAV3_HUMANS22AB_HUMANHPRD18985008 details
CAV3_HUMANSVIL_HUMANHPRD12711699 details
CAV3_HUMANGNAS2_HUMANHPRD7797570 details
CAV3_HUMANGNAS1_HUMANHPRD7797570 details
CAV3_HUMANNOS1_HUMANHPRD9353265 details