Entity Details

Primary name CXCR4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP61073
EntryNameCXCR4_HUMAN
FullNameC-X-C chemokine receptor type 4
TaxID9606
Evidenceevidence at protein level
Length352
SequenceStatuscomplete
DateCreated2004-04-26
DateModified2021-06-02

Ontological Relatives

GenesCXCR4

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001618 virus receptor activity
GO:0001666 response to hypoxia
GO:0001764 neuron migration
GO:0002064 epithelial cell development
GO:0002407 dendritic cell chemotaxis
GO:0003779 actin binding
GO:0004930 G protein-coupled receptor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007411 axon guidance
GO:0007420 brain development
GO:0008038 neuron recognition
GO:0009615 response to virus
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0014823 response to activity
GO:0015026 coreceptor activity
GO:0016021 integral component of membrane
GO:0016493 C-C chemokine receptor activity
GO:0016494 C-X-C chemokine receptor activity
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0019722 calcium-mediated signaling
GO:0019957 C-C chemokine binding
GO:0022008 neurogenesis
GO:0022029 telencephalon cell migration
GO:0030054 cell junction
GO:0030155 regulation of cell adhesion
GO:0031252 cell leading edge
GO:0031410 cytoplasmic vesicle
GO:0031625 ubiquitin protein ligase binding
GO:0032027 myosin light chain binding
GO:0032991 protein-containing complex
GO:0035470 positive regulation of vascular wound healing
GO:0035690 cellular response to drug
GO:0038147 C-X-C motif chemokine 12 receptor activity
GO:0038160 CXCL12-activated CXCR4 signaling pathway
GO:0043067 regulation of programmed cell death
GO:0043130 ubiquitin binding
GO:0043217 myelin maintenance
GO:0043278 response to morphine
GO:0044409 entry into host
GO:0045446 endothelial cell differentiation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0050792 regulation of viral process
GO:0050920 regulation of chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051924 regulation of calcium ion transport
GO:0060048 cardiac muscle contraction
GO:0060326 cell chemotaxis
GO:0061154 endothelial tube morphogenesis
GO:0070062 extracellular exosome
GO:0071345 cellular response to cytokine stimulus
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1903861 positive regulation of dendrite extension
GO:1905322 positive regulation of mesenchymal stem cell migration
GO:1990478 response to ultrasound
GO:2000448 positive regulation of macrophage migration inhibitory factor signaling pathway

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Early endosome
Late endosome
Lysosome

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000355 Chemokine receptor familyFamilyFamily
IPR001277 CXC chemokine receptor 4/atypical chemokine receptor 2FamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain
IPR022726 CXC chemokine receptor 4 N-terminal domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00452 FramycetinDrugbanksmall molecule
DB05501 AMD-070Drugbanksmall molecule
DB06809 PlerixaforDrugbanksmall molecule
DB12698 IbalizumabDrugbankbiotech

Interactions

60 interactions

InteractorPartnerSourcesPublicationsLink
CXCR4_HUMANCCR5_HUMANBioGRID, DIP, HPRD, IntAct12429730 15660419 18632580 details
CXCR4_HUMANAT132_HUMANBioGRID, IntAct22645275 details
CXCR4_HUMANITCH_HUMANBioGRID19116316 22275353 24489825 28264927 details
CXCR4_HUMANB2MG_HUMANBioGRID18083706 details
CXCR4_HUMANCXCR3_HUMANIntAct23170857 details
CXCR4_HUMANTLR2_HUMANDIP, I2D18765807 20802527 details
CXCR4_HUMANR113A_HUMANBioGRID28978524 details
CXCR4_HUMANACKR3_HUMANIntAct19380869 21730065 25775528 27331810 28862946 29386406 details
CXCR4_HUMANMYBB_HUMANBioGRID, IntAct21988832 details
CXCR4_HUMANCXCR4_HUMANHPRD, IntAct10506573 12433920 19380869 23170857 details
CXCR4_HUMANUBP14_HUMANBioGRID19106094 details
CXCR4_HUMANGNAI1_HUMANHPRD, IntAct10506573 19380869 details
CXCR4_HUMANHMGB1_HUMANBioGRID25495026 details
CXCR4_HUMANHIF1A_HUMANBioGRID17083723 details
CXCR4_HUMANELNE_HUMANHPRD12531874 details
CXCR4_HUMANARBK2_HUMANBioGRID, HPRD11668182 details
CXCR4_HUMANF10A1_HUMANBioGRID11751889 details
CXCR4_HUMANPDIA1_HUMANBioGRID14592831 details
CXCR4_HUMANPTPRC_HUMANHPRD, MINT12519755 21912642 details
CXCR4_HUMANSTAM1_HUMANBioGRID20505072 22275353 details
CXCR4_HUMANSTAT2_HUMANHPRD10506573 details
CXCR4_HUMANMYH9_HUMANHPRD, IntAct12421915 details
CXCR4_HUMANADA1A_HUMANIntAct25775528 27331810 28862946 details
CXCR4_HUMANSTAT1_HUMANHPRD10506573 details
CXCR4_HUMANPECA1_HUMANIntAct24497640 details
CXCR4_HUMANSOCS3_HUMANBioGRID, HPRD12163560 details
CXCR4_HUMANVAV_HUMANHPRD15618472 details
CXCR4_HUMANADA1D_HUMANIntAct28862946 29426850 details
CXCR4_HUMANJAK2_HUMANBioGRID, HPRD10506573 details
CXCR4_HUMANUBC_HUMANBioGRID30195032 details
CXCR4_HUMANBIRC3_HUMANBioGRID30948266 details
CXCR4_HUMANCAV1_HUMANBioGRID22275353 details
CXCR4_HUMANSOCS1_HUMANBioGRID, HPRD12163560 29991678 details
CXCR4_HUMANIQGA1_HUMANBioGRID30948266 details
CXCR4_HUMANDREB_HUMANIntAct20215400 23926103 details
CXCR4_HUMANSDF1_HUMANBioGRID, HPRD10233851 21757744 25495026 8752281 details
CXCR4_HUMANARRB2_HUMANHPRD10644702 details
CXCR4_HUMANCXL14_HUMANMINT23669361 details
CXCR4_HUMANEAA3_HUMANBioGRID, IntAct27173435 unassigned1312 details
CXCR4_HUMANV1AR_HUMANIntAct29386406 details
CXCR4_HUMANHG2A_HUMANMINT19665027 details
CXCR4_HUMANADA1B_HUMANIntAct25775528 28862946 29426850 details
CXCR4_HUMANRALA_HUMANBioGRID30948266 details
CXCR4_HUMANCD4_HUMANBioGRID, HPRD, UniProt10816381 14592831 15660419 details
CXCR4_HUMANHLAB_HUMANBioGRID18083706 details
CXCR4_HUMANSTA5B_HUMANHPRD10506573 details
CXCR4_HUMANJAK3_HUMANBioGRID, HPRD10506573 details
CXCR4_HUMANJAK1_HUMANHPRD12163560 details
CXCR4_HUMANGNA13_HUMANBioGRID, HPRD, Molecular Connections11994484 23773523 details
CXCR4_HUMANCXCR5_HUMANBioGRID, Molecular Connections23773523 details
CXCR4_HUMANFAK1_HUMANBioGRID11668182 details
CXCR4_HUMANSDC4_HUMANHPRD15819887 details
CXCR4_HUMANDPP4_HUMANHPRD11278278 details
CXCR4_HUMANCATG_HUMANHPRD12531874 details
CXCR4_HUMANMUC24_HUMANMolecular Connections24094005 details
CXCR4_HUMANPTN11_HUMANBioGRID, HPRD11157475 details
CXCR4_HUMANMTSS1_HUMANBioGRID28264927 details
CXCR4_HUMANHSP7C_HUMANHPRD16365278 details
CXCR4_HUMANSTAT3_HUMANHPRD10506573 details
CXCR4_HUMANPTN6_HUMANBioGRID, HPRD10506573 details