Entity Details

Primary name SHPS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78324
EntryNameSHPS1_HUMAN
FullNameTyrosine-protein phosphatase non-receptor type substrate 1
TaxID9606
Evidenceevidence at protein level
Length504
SequenceStatuscomplete
DateCreated2003-03-28
DateModified2021-06-02

Ontological Relatives

GenesSIRPA

GO terms

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GOName
GO:0001933 negative regulation of protein phosphorylation
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007155 cell adhesion
GO:0009986 cell surface
GO:0010468 regulation of gene expression
GO:0016020 membrane
GO:0016477 cell migration
GO:0017124 SH3 domain binding
GO:0019903 protein phosphatase binding
GO:0030695 GTPase regulator activity
GO:0032649 regulation of interferon-gamma production
GO:0032651 regulation of interleukin-1 beta production
GO:0032675 regulation of interleukin-6 production
GO:0032680 regulation of tumor necrosis factor production
GO:0032688 negative regulation of interferon-beta production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0035696 monocyte extravasation
GO:0043312 neutrophil degranulation
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045428 regulation of nitric oxide biosynthetic process
GO:0046329 negative regulation of JNK cascade
GO:0050728 negative regulation of inflammatory response
GO:0050765 negative regulation of phagocytosis
GO:0050766 positive regulation of phagocytosis
GO:0050870 positive regulation of T cell activation
GO:0050900 leukocyte migration
GO:0070062 extracellular exosome
GO:0070301 cellular response to hydrogen peroxide
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070821 tertiary granule membrane
GO:0071222 cellular response to lipopolysaccharide
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071349 cellular response to interleukin-12
GO:0071641 negative regulation of macrophage inflammatory protein 1 alpha production
GO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production
GO:0086080 protein binding involved in heterotypic cell-cell adhesion
GO:0098632 cell-cell adhesion mediator activity
GO:0101003 ficolin-1-rich granule membrane
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:1903720 negative regulation of I-kappaB phosphorylation
GO:1990405 protein antigen binding
GO:1990782 protein tyrosine kinase binding

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR003597 Immunoglobulin C1-setDomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

72 interactions

InteractorPartnerSourcesPublicationsLink
SHPS1_HUMANNOL3_HUMANBioGRID, HPRD, IntAct16189514 32296183 details
SHPS1_HUMANTRIM2_HUMANBioGRID, HPRD, IntAct16189514 25416956 32296183 details
SHPS1_HUMANPTN6_HUMANBioGRID, HPRD, UniProt10660565 10660620 14662855 8943344 9632768 details
SHPS1_HUMANSHIP1_HUMANUniProt24642916 details
SHPS1_HUMANCD47_HUMANHPRD, IntAct16291597 17070842 9872987 details
SHPS1_HUMANPTN11_HUMANBioGRID, HPRD, IntAct10962556 15888547 19299420 20473329 8943344 details
SHPS1_HUMANK1C15_HUMANBioGRID25416956 details
SHPS1_HUMANK1H1_HUMANBioGRID25416956 32296183 details
SHPS1_HUMANTRI27_HUMANBioGRID25416956 details
SHPS1_HUMANK1C40_HUMANBioGRID25416956 details
SHPS1_HUMANCCD57_HUMANBioGRID25416956 32296183 details
SHPS1_HUMANMATK_HUMANBioGRID17999719 19299420 21799000 details
SHPS1_HUMANIGF1R_HUMANBioGRID21799000 details
SHPS1_HUMANHSP7C_HUMANBioGRID19299420 details
SHPS1_HUMANBIP_HUMANBioGRID19299420 details
SHPS1_HUMANTCPZ_HUMANBioGRID19299420 details
SHPS1_HUMANHS90B_HUMANBioGRID19299420 details
SHPS1_HUMANCALR_HUMANBioGRID19299420 details
SHPS1_HUMANHS71A_HUMANBioGRID19299420 details
SHPS1_HUMANHS71B_HUMANBioGRID19299420 details
SHPS1_HUMANENPL_HUMANBioGRID19299420 details
SHPS1_HUMANGRP75_HUMANBioGRID19299420 details
SHPS1_HUMANIF2P_HUMANBioGRID19299420 details
SHPS1_HUMANRS8_HUMANBioGRID19299420 details
SHPS1_HUMANELOA1_HUMANBioGRID19299420 details
SHPS1_HUMANFUBP1_HUMANBioGRID19299420 details
SHPS1_HUMANSAFB2_HUMANBioGRID19299420 details
SHPS1_HUMANSPT6H_HUMANBioGRID19299420 details
SHPS1_HUMANDDX10_HUMANBioGRID19299420 details
SHPS1_HUMANDDX6_HUMANBioGRID19299420 details
SHPS1_HUMANSTAT1_HUMANBioGRID19299420 details
SHPS1_HUMANTBX3_HUMANBioGRID19299420 details
SHPS1_HUMANILK_HUMANBioGRID19299420 details
SHPS1_HUMANNEK1_HUMANBioGRID19299420 details
SHPS1_HUMANCDK16_HUMANBioGRID19299420 details
SHPS1_HUMANPTN7_HUMANBioGRID19299420 details
SHPS1_HUMANPTPRA_HUMANBioGRID19299420 details
SHPS1_HUMANPPM1B_HUMANBioGRID19299420 details
SHPS1_HUMANAKT1_HUMANBioGRID19299420 details
SHPS1_HUMANKTN1_HUMANBioGRID19299420 details
SHPS1_HUMANARF4_HUMANBioGRID19299420 details
SHPS1_HUMANGNL1_HUMANBioGRID19299420 details
SHPS1_HUMANMX1_HUMANBioGRID19299420 details
SHPS1_HUMANACTN1_HUMANBioGRID19299420 details
SHPS1_HUMANVIME_HUMANBioGRID19299420 details
SHPS1_HUMANFLNA_HUMANBioGRID19299420 details
SHPS1_HUMANPROF1_HUMANBioGRID19299420 details
SHPS1_HUMANK22E_HUMANBioGRID19299420 details
SHPS1_HUMANK1C10_HUMANBioGRID19299420 details
SHPS1_HUMANCAPZB_HUMANBioGRID19299420 details
SHPS1_HUMANNEXN_HUMANBioGRID19299420 details
SHPS1_HUMANNU1M_HUMANBioGRID19299420 details
SHPS1_HUMANPAHX_HUMANBioGRID19299420 details
SHPS1_HUMANNOX4_HUMANBioGRID19299420 details
SHPS1_HUMANTCTP_HUMANBioGRID19299420 details
SHPS1_HUMANNUCB1_HUMANBioGRID19299420 details
SHPS1_HUMANFRIH_HUMANBioGRID19299420 details
SHPS1_HUMANCO6A2_HUMANBioGRID19299420 details
SHPS1_HUMANCD81_HUMANBioGRID19299420 details
SHPS1_HUMANARHG6_HUMANBioGRID19299420 details
SHPS1_HUMANPSA6_HUMANBioGRID19299420 details
SHPS1_HUMANPRS8_HUMANBioGRID19299420 details
SHPS1_HUMANSOS1_HUMANBioGRID19299420 details
SHPS1_HUMANSMG7_HUMANBioGRID19299420 details
SHPS1_HUMANHSP74_HUMANBioGRID19299420 details
SHPS1_HUMANTRI23_HUMANBioGRID32296183 details
SHPS1_HUMANKRT34_HUMANBioGRID32296183 details
SHPS1_HUMANDYLT1_HUMANBioGRID32296183 details
SHPS1_HUMANHSF2B_HUMANBioGRID32296183 details
SHPS1_HUMANJAK2_HUMANBioGRID, HPRD10842184 details
SHPS1_HUMANSHC1_HUMANBioGRID15888547 details
SHPS1_HUMANIL1AP_HUMANHPRD12483539 details