Entity Details

Primary name CDK5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ00535
EntryNameCDK5_HUMAN
FullNameCyclin-dependent-like kinase 5
TaxID9606
Evidenceevidence at protein level
Length292
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesCDK5

GO terms

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GOName
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000226 microtubule cytoskeleton organization
GO:0001764 neuron migration
GO:0001963 synaptic transmission, dopaminergic
GO:0002039 p53 binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005176 ErbB-2 class receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007005 mitochondrion organization
GO:0007160 cell-matrix adhesion
GO:0007268 chemical synaptic transmission
GO:0007409 axonogenesis
GO:0007416 synapse assembly
GO:0007519 skeletal muscle tissue development
GO:0008045 motor neuron axon guidance
GO:0008542 visual learning
GO:0009611 response to wounding
GO:0014044 Schwann cell development
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016079 synaptic vesicle exocytosis
GO:0016241 regulation of macroautophagy
GO:0016301 kinase activity
GO:0016310 phosphorylation
GO:0016533 protein kinase 5 complex
GO:0016572 histone phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019233 sensory perception of pain
GO:0019901 protein kinase binding
GO:0021697 cerebellar cortex formation
GO:0021766 hippocampus development
GO:0021819 layer formation in cerebral cortex
GO:0021954 central nervous system neuron development
GO:0022038 corpus callosum development
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030175 filopodium
GO:0030182 neuron differentiation
GO:0030334 regulation of cell migration
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030517 negative regulation of axon extension
GO:0030549 acetylcholine receptor activator activity
GO:0030866 cortical actin cytoskeleton organization
GO:0031175 neuron projection development
GO:0031397 negative regulation of protein ubiquitination
GO:0031594 neuromuscular junction
GO:0031914 negative regulation of synaptic plasticity
GO:0032092 positive regulation of protein binding
GO:0032801 receptor catabolic process
GO:0034352 positive regulation of glial cell apoptotic process
GO:0035249 synaptic transmission, glutamatergic
GO:0035418 protein localization to synapse
GO:0042501 serine phosphorylation of STAT protein
GO:0042981 regulation of apoptotic process
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043113 receptor clustering
GO:0043125 ErbB-3 class receptor binding
GO:0043204 perikaryon
GO:0043525 positive regulation of neuron apoptotic process
GO:0045786 negative regulation of cell cycle
GO:0045860 positive regulation of protein kinase activity
GO:0045861 negative regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045956 positive regulation of calcium ion-dependent exocytosis
GO:0046777 protein autophosphorylation
GO:0046826 negative regulation of protein export from nucleus
GO:0046875 ephrin receptor binding
GO:0048148 behavioral response to cocaine
GO:0048156 tau protein binding
GO:0048167 regulation of synaptic plasticity
GO:0048488 synaptic vesicle endocytosis
GO:0048489 synaptic vesicle transport
GO:0048511 rhythmic process
GO:0048675 axon extension
GO:0048709 oligodendrocyte differentiation
GO:0048813 dendrite morphogenesis
GO:0050321 tau-protein kinase activity
GO:0051301 cell division
GO:0051402 neuron apoptotic process
GO:0051879 Hsp90 protein binding
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060079 excitatory postsynaptic potential
GO:0061001 regulation of dendritic spine morphogenesis
GO:0070509 calcium ion import
GO:0090314 positive regulation of protein targeting to membrane
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098793 presynapse
GO:0098883 synapse pruning
GO:0098978 glutamatergic synapse
GO:0099635 voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901215 negative regulation of neuron death
GO:1901387 positive regulation of voltage-gated calcium channel activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1903076 regulation of protein localization to plasma membrane
GO:1903421 regulation of synaptic vesicle recycling
GO:1904646 cellular response to amyloid-beta
GO:2000251 positive regulation of actin cytoskeleton reorganization

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm
Nucleus
Perikaryon

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB02052 Indirubin-3'-monoximeDrugbanksmall molecule
DB02116 OlomoucineDrugbanksmall molecule
DB02950 HymenialdisineDrugbanksmall molecule
DB03428 SU9516Drugbanksmall molecule
DB03496 AlvocidibDrugbanksmall molecule
DB04014 AlsterpaulloneDrugbanksmall molecule
DB07364 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINEDrugbanksmall molecule

Interactions

116 interactions

InteractorPartnerSourcesPublicationsLink
CDK5_HUMANCD5R1_HUMANBioGRID, DIP, HPRD, IntAct10604467 11389014 11583627 12223541 14521924 15689152 17036052 17591690 17762160 20133653 21220307 22654103 23602568 25331900 26186194 26264872 28514442 28637746 31319193 details
CDK5_HUMANTAU_HUMANBioGRID, HPRD, MINT11181841 1181841 11943163 12387894 16262633 16519508 17045592 17078951 19527721 26268594 7566346 9199504 9353289 9565682 9614189 9735171 9771888 9832145 details
CDK5_HUMANCDN1B_HUMANBioGRID, HPRD, IntAct15890360 23455922 23543736 23602568 25852190 26186194 28514442 details
CDK5_HUMANCDN1A_HUMANBioGRID, IntAct15890360 23443559 23455922 23602568 30833792 details
CDK5_HUMANLMTK1_HUMANBioGRID, IntAct14521924 details
CDK5_HUMANCABL1_HUMANBioGRID, HPRD, IntAct, MINT10896159 11733001 11955625 20559324 23455922 23602568 25852190 26186194 28514442 details
CDK5_HUMANCDC37_HUMANBioGRID, HPRD, IntAct21163940 9150368 details
CDK5_HUMANMAST1_HUMANBioGRID, IntAct21163940 details
CDK5_HUMANPSN1_HUMANBioGRID, HPRD, IntAct12056836 21163940 details
CDK5_HUMANRNF32_HUMANBioGRID, IntAct21163940 details
CDK5_HUMANHEM1_HUMANBioGRID, MINT21900206 details
CDK5_HUMANCREL2_HUMANMINT21900206 details
CDK5_HUMANPP1A_HUMANMINT11320080 details
CDK5_HUMANPPARG_HUMANBioGRID, IntAct22078880 22584573 23178929 31319193 details
CDK5_HUMANCCND2_HUMANBioGRID, HPRD, IntAct23455922 23602568 25416956 26186194 26871637 27107012 28514442 32296183 9422379 details
CDK5_HUMANCCND3_HUMANBioGRID, IntAct23455922 23602568 26186194 28514442 32296183 details
CDK5_HUMANAP2A_HUMANIntAct24835590 details
CDK5_HUMANCCNI_HUMANBioGRID, IntAct25852190 32296183 details
CDK5_HUMANSPDE4_HUMANBioGRID, IntAct32296183 details
CDK5_HUMANSPDYA_HUMANBioGRID, IntAct32296183 details
CDK5_HUMANHOOK1_HUMANIntAct32814053 details
CDK5_HUMANARP3_HUMANIntAct32814053 details
CDK5_HUMANNUMBL_HUMANIntAct32814053 details
CDK5_HUMANTBP_HUMANIntAct32814053 details
CDK5_HUMANPPIA_HUMANIntAct32814053 details
CDK5_HUMANBDNF_HUMANIntAct32814053 details
CDK5_HUMANPRKN_HUMANBioGRID, IntAct17327227 32814053 details
CDK5_HUMANA4_HUMANBioGRID, HPRD, IntAct10936190 15178331 21832049 32814053 8764598 details
CDK5_HUMANLMTK2_HUMANBioGRID12832520 details
CDK5_HUMANNEST_HUMANBioGRID, HPRD11278541 12832492 17036052 details
CDK5_HUMANNDEL1_HUMANBioGRID, HPRD11163260 12796778 details
CDK5_HUMANPAK1_HUMANBioGRID, HPRD11604394 details
CDK5_HUMANCDK16_HUMANBioGRID, HPRD12084709 details
CDK5_HUMANCK5P2_HUMANBioGRID10915792 details
CDK5_HUMANSTX1A_HUMANBioGRID, HPRD9478941 details
CDK5_HUMANP53_HUMANBioGRID, HPRD10884347 11483158 12064478 17591690 details
CDK5_HUMANNEDD4_HUMANBioGRID19953087 details
CDK5_HUMANTLN1_HUMANBioGRID19363486 details
CDK5_HUMANBAG6_HUMANBioGRID21900206 details
CDK5_HUMANNED4L_HUMANBioGRID19953087 details
CDK5_HUMANH10_HUMANBioGRID12970441 details
CDK5_HUMANFZR1_HUMANBioGRID18818692 22654103 23589330 details
CDK5_HUMANRL34_HUMANBioGRID10049762 details
CDK5_HUMANRB_HUMANBioGRID10049762 details
CDK5_HUMANDAB1_HUMANBioGRID, HPRD12077184 18076569 details
CDK5_HUMANDYN1_HUMANBioGRID, HPRD12855954 15834155 details
CDK5_HUMANKI26B_HUMANBioGRID22768111 details
CDK5_HUMANAMPH_HUMANBioGRID, HPRD11113134 17419807 details
CDK5_HUMANMBP_HUMANBioGRID17906618 details
CDK5_HUMANHTRA2_HUMANBioGRID17906618 details
CDK5_HUMANH15_HUMANBioGRID11516829 details
CDK5_HUMANMPIP2_HUMANBioGRID11516829 22899714 details
CDK5_HUMANMPIP1_HUMANBioGRID22899714 details
CDK5_HUMANMPIP3_HUMANBioGRID22899714 details
CDK5_HUMANYBOX3_HUMANBioGRID10100871 details
CDK5_HUMANFYV1_HUMANBioGRID28637746 details
CDK5_HUMANH11_HUMANBioGRID10604467 details
CDK5_HUMANMEOX2_HUMANBioGRID32296183 details
CDK5_HUMANTRI59_HUMANBioGRID31488827 details
CDK5_HUMANCHIN_HUMANHPRD15013773 details
CDK5_HUMANCABL2_HUMANBioGRID, HPRD, IntAct11955625 23455922 23602568 25852190 details
CDK5_HUMANCCNC_HUMANIntAct25852190 details
CDK5_HUMANCOPZ1_HUMANBioGRID, IntAct27173435 unassigned1312 details
CDK5_HUMANTCP4_HUMANBioGRID, IntAct27173435 unassigned1312 details
CDK5_HUMANSARNP_HUMANBioGRID, IntAct27173435 unassigned1312 details
CDK5_HUMANRRP44_HUMANBioGRID, IntAct27173435 unassigned1312 details
CDK5_HUMANSCYL2_HUMANBioGRID, IntAct27173435 unassigned1312 details
CDK5_HUMANSEPT7_HUMANBioGRID, IntAct27173435 unassigned1312 details
CDK5_HUMANPRCC_HUMANBioGRID, IntAct27173435 unassigned1312 details
CDK5_HUMANGORS2_HUMANBioGRID, IntAct27173435 unassigned1312 details
CDK5_HUMANSEP11_HUMANBioGRID, IntAct27173435 unassigned1312 details
CDK5_HUMANCHRD1_HUMANBioGRID, IntAct27173435 unassigned1312 details
CDK5_HUMANDRG1_HUMANBioGRID, IntAct27173435 unassigned1312 details
CDK5_HUMANSHLB1_HUMANBioGRID, IntAct27173435 unassigned1312 details
CDK5_HUMANLRRK2_HUMANBioGRID, IntAct26268594 31046837 details
CDK5_HUMANSTXB1_HUMANBioGRID, HPRD12963086 details
CDK5_HUMANGAK_HUMANBioGRID, HPRD9013862 details
CDK5_HUMANHDAC4_HUMANBioGRID16356933 details
CDK5_HUMANPCNA_HUMANBioGRID, HPRD11254741 7949095 9545286 details
CDK5_HUMANODFP1_HUMANBioGRID17762160 details
CDK5_HUMANUCHL1_HUMANBioGRID23543736 details
CDK5_HUMANCDK5_HUMANBioGRID, HPRD11583627 23602568 details
CDK5_HUMANCHIP_HUMANBioGRID26206088 details
CDK5_HUMANUBE2A_HUMANBioGRID28031328 details
CDK5_HUMANGSK3B_HUMANBioGRID, HPRD15652488 16519508 details
CDK5_HUMANFKBP5_HUMANBioGRID26602018 details
CDK5_HUMANFKBP4_HUMANBioGRID26602018 details
CDK5_HUMANDNMT1_HUMANBioGRID26602018 details
CDK5_HUMANBRCC3_HUMANBioGRID31787240 details
CDK5_HUMANTULP3_HUMANBioGRID33187986 details
CDK5_HUMANACTN1_HUMANHPRD12223541 details
CDK5_HUMANIPP2_HUMANHPRD11320080 details
CDK5_HUMANSET_HUMANHPRD11741927 details
CDK5_HUMANEZRI_HUMANHPRD12769842 details
CDK5_HUMANFYN_HUMANHPRD12372285 details
CDK5_HUMANNMDE1_HUMANHPRD11675505 details
CDK5_HUMANMP2K1_HUMANHPRD11684694 details
CDK5_HUMANABL1_HUMANHPRD10896159 details
CDK5_HUMANSRC_HUMANHPRD10544291 details
CDK5_HUMANERBB3_HUMANHPRD12824184 details
CDK5_HUMANDCX_HUMANHPRD14741103 15345747 details
CDK5_HUMANSYN1_HUMANHPRD8702879 details
CDK5_HUMANPURA_HUMANHPRD12972605 details
CDK5_HUMANMEF2A_HUMANHPRD12691662 details
CDK5_HUMANKC1D_HUMANHPRD10500146 details
CDK5_HUMANCCNG1_HUMANHPRD9013862 details
CDK5_HUMANMK10_HUMANHPRD11823425 details
CDK5_HUMANCD5R2_HUMANHPRD10683146 details
CDK5_HUMANPPR1B_HUMANHPRD10604473 details
CDK5_HUMANPTN2_HUMANHPRD15030318 details
CDK5_HUMANSYNJ1_HUMANHPRD14704270 details
CDK5_HUMANCK5P1_HUMANHPRD11882646 details
CDK5_HUMANFSD1_HUMANHPRD12154070 details
CDK5_HUMANCROC4_HUMANHPRD10995546 details
CDK5_HUMANPI51C_HUMANHPRD17290217 details
CDK5_HUMANWASF1_HUMANHPRD16862120 details