Entity Details

Primary name NRG1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02297
EntryNameNRG1_HUMAN
FullNamePro-neuregulin-1, membrane-bound isoform
TaxID9606
Evidenceevidence at protein level
Length640
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesNRG1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003712 transcription coregulator activity
GO:0005102 signaling receptor binding
GO:0005125 cytokine activity
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0007154 cell communication
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0007399 nervous system development
GO:0008083 growth factor activity
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0014032 neural crest cell development
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0030154 cell differentiation
GO:0030296 protein tyrosine kinase activator activity
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
GO:0030307 positive regulation of cell growth
GO:0030879 mammary gland development
GO:0030971 receptor tyrosine kinase binding
GO:0031334 positive regulation of protein-containing complex assembly
GO:0032148 activation of protein kinase B activity
GO:0035556 intracellular signal transduction
GO:0038127 ERBB signaling pathway
GO:0038128 ERBB2 signaling pathway
GO:0038129 ERBB3 signaling pathway
GO:0038130 ERBB4 signaling pathway
GO:0042060 wound healing
GO:0043125 ErbB-3 class receptor binding
GO:0043624 cellular protein complex disassembly
GO:0045499 chemorepellent activity
GO:0045785 positive regulation of cell adhesion
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048513 animal organ development
GO:0051048 negative regulation of secretion
GO:0051155 positive regulation of striated muscle cell differentiation
GO:0051897 positive regulation of protein kinase B signaling
GO:0055007 cardiac muscle cell differentiation
GO:0055012 ventricular cardiac muscle cell differentiation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060379 cardiac muscle cell myoblast differentiation
GO:0060956 endocardial cell differentiation
GO:0098978 glutamatergic synapse
GO:0099059 integral component of presynaptic active zone membrane
GO:0099061 integral component of postsynaptic density membrane
GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization
GO:0099560 synaptic membrane adhesion
GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation
GO:2000145 regulation of cell motility
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Cell membrane
Membrane
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR002154 Neuregulin, C-terminalDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR018250 Neuregulin-1FamilyFamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR040180 NeuregulinFamilyFamily

Diseases

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