Entity Details

Primary name CP27A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02318
EntryNameCP27A_HUMAN
FullNameSterol 26-hydroxylase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length531
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesCYP27A1

GO terms

Show/Hide Table
GOName
GO:0005506 iron ion binding
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0006699 bile acid biosynthetic process
GO:0006707 cholesterol catabolic process
GO:0008203 cholesterol metabolic process
GO:0008395 steroid hydroxylase activity
GO:0016125 sterol metabolic process
GO:0020037 heme binding
GO:0030343 vitamin D3 25-hydroxylase activity
GO:0031073 cholesterol 26-hydroxylase activity
GO:0036378 calcitriol biosynthetic process from calciol
GO:0047748 cholestanetetraol 26-dehydrogenase activity
GO:0047749 cholestanetriol 26-monooxygenase activity

Subcellular Location

Show/Hide Table
Subcellular Location
Mitochondrion inner membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002401 Cytochrome P450, E-class, group IFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
213700 OMIMCerebrotendinous xanthomatosis (CTX)Rare sterol storage disorder characterized clinically by progressive neurologic dysfunction, premature atherosclerosis, and cataracts. The disease is caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB00082 PegvisomantDrugbankbiotech
DB00153 ErgocalciferolDrugbanksmall molecule
DB00169 CholecalciferolDrugbanksmall molecule
DB06410 DoxercalciferolDrugbanksmall molecule
DB06777 Chenodeoxycholic acidDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
CP27A_HUMANPRDX4_HUMANBioGRID, IntAct21988832 details