Entity Details

Primary name MP2K1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02750
EntryNameMP2K1_HUMAN
FullNameDual specificity mitogen-activated protein kinase kinase 1
TaxID9606
Evidenceevidence at protein level
Length393
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesMAP2K1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005078 MAP-kinase scaffold activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007507 heart development
GO:0008022 protein C-terminus binding
GO:0008285 negative regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0018107 peptidyl-threonine phosphorylation
GO:0021697 cerebellar cortex formation
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030878 thyroid gland development
GO:0032872 regulation of stress-activated MAPK cascade
GO:0043539 protein serine/threonine kinase activator activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0047485 protein N-terminus binding
GO:0048538 thymus development
GO:0048679 regulation of axon regeneration
GO:0048870 cell motility
GO:0050772 positive regulation of axonogenesis
GO:0060020 Bergmann glial cell differentiation
GO:0060324 face development
GO:0060440 trachea formation
GO:0060502 epithelial cell proliferation involved in lung morphogenesis
GO:0060674 placenta blood vessel development
GO:0060711 labyrinthine layer development
GO:0070371 ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090170 regulation of Golgi inheritance
GO:0090398 cellular senescence
GO:0097110 scaffold protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:2000641 regulation of early endosome to late endosome transport

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Disease IDSourceNameDescription
155950 OMIMMelorheostosis, isolated (MEL)A sclerosing bone disorder characterized by hyperostosis of the cortex of tubular bones, frequently involving one limb. The lesions may be accompanied by abnormalities of adjacent soft tissue, joint contractures, sclerodermatous skin lesions, muscle atrophy, or hemangioma. The disease is caused by variants affecting the gene represented in this entry.
615279 OMIMCardiofaciocutaneous syndrome 3 (CFC3)A form of cardiofaciocutaneous syndrome, a multiple congenital anomaly disorder characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. Distinctive features of CFC3 include macrostomia and horizontal shape of palpebral fissures. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB02152 K-252aDrugbanksmall molecule
DB03115 5-Bromo-N-[(2S)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamideDrugbanksmall molecule
DB05239 CobimetinibDrugbanksmall molecule
DB06616 BosutinibDrugbanksmall molecule
DB06892 (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamideDrugbanksmall molecule
DB07046 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamideDrugbanksmall molecule
DB07101 PD-0325901Drugbanksmall molecule
DB08130 N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamineDrugbanksmall molecule
DB08208 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDEDrugbanksmall molecule
DB08911 TrametinibDrugbanksmall molecule
DB11689 SelumetinibDrugbanksmall molecule

Interactions

90 interactions

InteractorPartnerSourcesPublicationsLink
MP2K1_HUMANMK01_HUMANBioGRID, HPRD, MINT10757792 11134045 11266467 11279118 11352917 11741894 11823456 12594221 12697810 12788955 17255949 19058874 21336309 21675959 23241949 24623782 27884160 8157000 details
MP2K1_HUMANBRAF_HUMANBioGRID, DIP, HPRD, IntAct16810323 16888650 17979178 18332145 19371126 20212043 23934108 24746704 25155755 25437913 25600339 26496610 27034005 27684187 28514442 31015455 31980649 7731720 8157000 8394352 8621729 9733801 details
MP2K1_HUMANRAF1_HUMANBioGRID, DIP, HPRD, IntAct, MINT10757792 10958680 11604401 15485920 15866172 16093354 17724343 17979178 18556463 19058874 19197339 20212043 21336309 23934108 24746704 25155755 26496610 27703006 31980649 7527398 7731720 8157000 8394352 8621729 9311917 9733801 details
MP2K1_HUMANARAF_HUMANBioGRID, HPRD, IntAct17979178 24114843 24746704 26496610 31980649 7731720 8157000 8394352 8621729 details
MP2K1_HUMANAPC_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANAURKA_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANBMR1A_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANMK03_HUMANBioGRID, HPRD, MINT10748187 19058874 19197339 8226933 8626767 9006895 9733512 details
MP2K1_HUMANERBB2_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANPEBP4_HUMANBioGRID, HPRD, MINT15302887 19197339 details
MP2K1_HUMANFBXW7_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANPGFRL_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANPK3CA_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANWNK1_HUMANBioGRID, IntAct20936779 details
MP2K1_HUMANSMAD2_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANBAX_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANBUB1_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANSTK11_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANCADH1_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANTGFR2_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANARF_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANM3K8_HUMANBioGRID, IntAct12832462 16291755 8631303 details
MP2K1_HUMANCTNA1_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANBANP_HUMANBioGRID, IntAct25416956 32296183 details
MP2K1_HUMANDCOR_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANMLH3_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANPKHF2_HUMANBioGRID, IntAct32296183 details
MP2K1_HUMANMSH6_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANPTPRJ_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANPEBP1_HUMANBioGRID, HPRD10757792 details
MP2K1_HUMANLTOR3_HUMANBioGRID, HPRD11266467 9733512 details
MP2K1_HUMANMP2K1_HUMANBioGRID, HPRD12697810 17979178 31980649 8226933 9733512 details
MP2K1_HUMANSRC_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANTCP11_HUMANBioGRID, IntAct32296183 details
MP2K1_HUMANTLR2_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANPIN1_HUMANUniProt20179161 details
MP2K1_HUMANM3K4_HUMANBioGRID, HPRD9841871 details
MP2K1_HUMANJIP3_HUMANBioGRID, HPRD10523642 11044439 details
MP2K1_HUMANHNRPD_HUMANBioGRID15231747 details
MP2K1_HUMANUBC9_HUMANBioGRID21336309 details
MP2K1_HUMANGRB10_HUMANBioGRID, HPRD9553107 details
MP2K1_HUMANITCH_HUMANBioGRID31015455 details
MP2K1_HUMANBMI1_HUMANBioGRID27878292 details
MP2K1_HUMANCDN2A_HUMANBioGRID24412244 details
MP2K1_HUMANMBP_HUMANBioGRID8617731 details
MP2K1_HUMANMK08_HUMANBioGRID16533805 details
MP2K1_HUMANPPARG_HUMANBioGRID17101779 21690289 details
MP2K1_HUMANKAT7_HUMANBioGRID23319590 details
MP2K1_HUMANTRIB3_HUMANIntAct15299019 details
MP2K1_HUMANM3K1_HUMANBioGRID, MINT10969079 14500727 17110930 details
MP2K1_HUMANTRIB1_HUMANHPRD, IntAct15299019 details
MP2K1_HUMANHLAB_HUMANIntAct17353931 details
MP2K1_HUMANKSR1_HUMANBioGRID, HPRD, IntAct11741534 11940661 15090600 15520859 17979178 18332145 26496610 27086506 31980649 details
MP2K1_HUMANCFLAR_HUMANMINT17110930 details
MP2K1_HUMAN1433B_HUMANBioGRID, IntAct10409742 17979178 24255178 31980649 details
MP2K1_HUMANBIRC6_HUMANHPRD, IntAct18329369 details
MP2K1_HUMANVRK2_HUMANIntAct20679487 22752157 details
MP2K1_HUMANYAP1_HUMANBioGRID, MINT24211253 27684187 details
MP2K1_HUMANKSR2_HUMANBioGRID, HPRD, IntAct12975377 27086506 details
MP2K1_HUMANFBW1A_HUMANBioGRID, MINT24211253 details
MP2K1_HUMANMP2K2_HUMANBioGRID, IntAct10409742 28514442 details
MP2K1_HUMANLTOR2_HUMANBioGRID11266467 details
MP2K1_HUMANMYC_HUMANBioGRID, HPRD, IntAct26496610 7957875 details
MP2K1_HUMANBRAP_HUMANBioGRID18332145 details
MP2K1_HUMANCALR_HUMANIntAct22752157 details
MP2K1_HUMANIQGA1_HUMANBioGRID24639526 27684187 details
MP2K1_HUMANVAV_HUMANBioGRID8900182 details
MP2K1_HUMANTRAF3_HUMANHPRD8626767 details
MP2K1_HUMANWDR83_HUMANBioGRID15118098 details
MP2K1_HUMANPAK1_HUMANHPRD9351825 details
MP2K1_HUMANZ3H7A_HUMANBioGRID29395067 details
MP2K1_HUMANKPCI_HUMANHPRD10848576 details
MP2K1_HUMANARRB2_HUMANBioGRID11226259 details
MP2K1_HUMANKS6A2_HUMANHPRD8939914 details
MP2K1_HUMANCDK5_HUMANHPRD11684694 details
MP2K1_HUMANRASH_HUMANBioGRID, HPRD7969158 details
MP2K1_HUMANCPNE1_HUMANHPRD12522145 details
MP2K1_HUMANNF2L2_HUMANBioGRID24704364 details
MP2K1_HUMANLSP1_HUMANBioGRID15090600 details
MP2K1_HUMANMK14_HUMANHPRD12697810 details
MP2K1_HUMANKS6A4_HUMANHPRD10806207 details
MP2K1_HUMANCASP9_HUMANHPRD12792650 details
MP2K1_HUMANPLK3_HUMANHPRD15021912 details
MP2K1_HUMANEP300_HUMANHPRD11278389 details
MP2K1_HUMANEGFR_HUMANHPRD12556561 details
MP2K1_HUMANCPNE4_HUMANHPRD12522145 details
MP2K1_HUMANKPCZ_HUMANHPRD11535599 details
MP2K1_HUMANPARVA_HUMANHPRD15353548 details
MP2K1_HUMANTRAF6_HUMANHPRD16313339 details
MP2K1_HUMANELK1_HUMANHPRD10716983 10997882 details