Entity Details

Primary name VMAT2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ05940
EntryNameVMAT2_HUMAN
FullNameSynaptic vesicular amine transporter
TaxID9606
Evidenceevidence at protein level
Length514
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesSLC18A2

GO terms

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GOName
GO:0001975 response to amphetamine
GO:0005335 serotonin:sodium symporter activity
GO:0005813 centrosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006836 neurotransmitter transport
GO:0007268 chemical synaptic transmission
GO:0007626 locomotory behavior
GO:0008021 synaptic vesicle
GO:0008504 monoamine transmembrane transporter activity
GO:0009636 response to toxic substance
GO:0009791 post-embryonic development
GO:0015842 aminergic neurotransmitter loading into synaptic vesicle
GO:0015844 monoamine transport
GO:0015872 dopamine transport
GO:0016020 membrane
GO:0022857 transmembrane transporter activity
GO:0030672 synaptic vesicle membrane
GO:0042137 sequestering of neurotransmitter
GO:0043195 terminal bouton
GO:0043231 intracellular membrane-bounded organelle
GO:0070083 clathrin-sculpted monoamine transport vesicle membrane
GO:0098691 dopaminergic synapse
GO:0098700 neurotransmitter loading into synaptic vesicle
GO:1903427 negative regulation of reactive oxygen species biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle membrane

Domains

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DomainNameCategoryType
IPR011701 Major facilitator superfamilyFamilyFamily
IPR020846 Major facilitator superfamily domainDomainDomain
IPR036259 MFS transporter superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00182 AmphetamineDrugbanksmall molecule
DB00206 ReserpineDrugbanksmall molecule
DB00368 NorepinephrineDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00579 MazindolDrugbanksmall molecule
DB00714 ApomorphineDrugbanksmall molecule
DB00865 BenzphetamineDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule
DB01089 DeserpidineDrugbanksmall molecule
DB01363 Ephedra sinica rootDrugbankbiotech
DB01364 EphedrineDrugbanksmall molecule
DB01442 MMDADrugbanksmall molecule
DB01454 MidomafetamineDrugbanksmall molecule
DB01472 4-MethoxyamphetamineDrugbanksmall molecule
DB01576 DextroamphetamineDrugbanksmall molecule
DB01577 MetamfetamineDrugbanksmall molecule
DB04821 NomifensineDrugbanksmall molecule
DB04844 TetrabenazineDrugbanksmall molecule
DB05381 HistamineDrugbanksmall molecule
DB06706 IsomethepteneDrugbanksmall molecule
DB06714 PropylhexedrineDrugbanksmall molecule
DB08839 SerotoninDrugbanksmall molecule
DB09363 Rauwolfia serpentina rootDrugbanksmall molecule
DB12161 DeutetrabenazineDrugbanksmall molecule