Entity Details

Primary name RBL2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ08999
EntryNameRBL2_HUMAN
FullNameRetinoblastoma-like protein 2
TaxID9606
Evidenceevidence at protein level
Length1139
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesRBL2

GO terms

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GOName
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0006325 chromatin organization
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010629 negative regulation of gene expression
GO:0030154 cell differentiation
GO:0043550 regulation of lipid kinase activity
GO:0051302 regulation of cell division
GO:0070062 extracellular exosome
GO:1990841 promoter-specific chromatin binding
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR002719 Retinoblastoma-associated protein, B-boxDomainDomain
IPR002720 Retinoblastoma-associated protein, A-boxDomainDomain
IPR013763 Cyclin-likeDomainDomain
IPR015030 Retinoblastoma-associated protein, C-terminalDomainDomain
IPR024599 Retinoblastoma-associated protein, N-terminalDomainDomain
IPR028308 Retinoblastoma-like protein 2FamilyFamily
IPR028309 Retinoblastoma protein familyFamilyFamily
IPR036915 Cyclin-like superfamilyFamilyHomologous superfamily

Diseases

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Interactions

54 interactions

InteractorPartnerSourcesPublicationsLink
RBL2_HUMANCTIP_HUMANBioGRID, HPRD, IntAct, MINT10449734 16600870 27107012 32296183 9721205 details
RBL2_HUMANLIN52_HUMANBioGRID, IntAct17531812 25917549 details
RBL2_HUMANE2F4_HUMANBioGRID, DIP, HPRD, IntAct, MINT11573202 12006580 12401786 16600870 17159899 17531812 17671431 20133863 22002537 23108140 9343408 9858615 details
RBL2_HUMANE2F5_HUMANBioGRID, HPRD, IntAct11756542 16600870 17531812 7760804 details
RBL2_HUMANCCNA2_HUMANBioGRID, HPRD, IntAct12006580 17531812 26186194 28514442 8253383 details
RBL2_HUMANCDK2_HUMANBioGRID, HPRD, IntAct10825149 17531812 23455922 23602568 25852190 26186194 28514442 9188854 9472014 9891079 details
RBL2_HUMANPP2AA_HUMANBioGRID, MINT12915404 15467457 details
RBL2_HUMANCDK6_HUMANBioGRID, IntAct22094256 details
RBL2_HUMANCDK4_HUMANBioGRID, IntAct22094256 details
RBL2_HUMANCCND3_HUMANBioGRID, HPRD, IntAct10572252 16600870 26186194 28514442 details
RBL2_HUMANPHS_HUMANBioGRID, IntAct20211142 details
RBL2_HUMANXBP1_HUMANBioGRID, IntAct20211142 details
RBL2_HUMANHBP1_HUMANBioGRID, HPRD9178770 details
RBL2_HUMANBRCA1_HUMANBioGRID11521194 details
RBL2_HUMANSNW1_HUMANBioGRID, HPRD12466551 details
RBL2_HUMANMCM7_HUMANBioGRID, HPRD9566894 details
RBL2_HUMANRAF1_HUMANBioGRID, HPRD9819434 details
RBL2_HUMANCCNA1_HUMANBioGRID, HPRD10022926 details
RBL2_HUMANTF3B_HUMANBioGRID, HPRD10330166 details
RBL2_HUMANPHB_HUMANBioGRID, HPRD10376528 details
RBL2_HUMANUBP4_HUMANBioGRID11571651 details
RBL2_HUMANSKP2_HUMANBioGRID12435635 12717421 details
RBL2_HUMANEZH2_HUMANBioGRID15077161 details
RBL2_HUMANSMCA4_HUMANBioGRID12434308 details
RBL2_HUMANTOP1_HUMANBioGRID12549820 details
RBL2_HUMANCCND1_HUMANBioGRID, HPRD16600870 details
RBL2_HUMANRINT1_HUMANBioGRID, HPRD16600870 details
RBL2_HUMANGRAM4_HUMANBioGRID16600870 details
RBL2_HUMANLBX1_HUMANBioGRID16600870 details
RBL2_HUMANDCTN1_HUMANBioGRID16600870 details
RBL2_HUMANLDHC_HUMANBioGRID16600870 details
RBL2_HUMANTP53B_HUMANBioGRID9233764 details
RBL2_HUMANDGKZ_HUMANBioGRID, HPRD, IntAct16286473 details
RBL2_HUMANLIN54_HUMANBioGRID, IntAct, MINT17531812 17671431 19725879 details
RBL2_HUMANLIN9_HUMANBioGRID, IntAct17159899 17531812 17671431 details
RBL2_HUMANLIN37_HUMANBioGRID, IntAct17531812 17671431 30206359 details
RBL2_HUMANRBL1_HUMANBioGRID, MINT15467457 17531812 details
RBL2_HUMANSUV91_HUMANBioGRID, HPRD12588981 details
RBL2_HUMANHDAC1_HUMANBioGRID, HPRD10969803 9724731 9858615 details
RBL2_HUMANCCNE1_HUMANBioGRID, HPRD8253383 9891079 details
RBL2_HUMANAATF_HUMANBioGRID12450794 details
RBL2_HUMANRBBP9_HUMANBioGRID, HPRD9697699 details
RBL2_HUMANTAF1_HUMANBioGRID, HPRD9242374 details
RBL2_HUMANID2_HUMANBioGRID, HPRD11034201 16776654 details
RBL2_HUMANPAI2_HUMANBioGRID16397580 details
RBL2_HUMANSKP1_HUMANBioGRID12717421 details
RBL2_HUMANCUL1_HUMANBioGRID12717421 details
RBL2_HUMANRAD50_HUMANBioGRID16600870 details
RBL2_HUMANE2F1_HUMANBioGRID12096339 12401786 details
RBL2_HUMANUBF1_HUMANHPRD11042686 details
RBL2_HUMANBRF2_HUMANHPRD10330166 details
RBL2_HUMANCREG1_HUMANHPRD9710587 details
RBL2_HUMANMNDA_HUMANHPRD16458891 details
RBL2_HUMANKMT5C_HUMANHPRD15750587 details