Entity Details

Primary name CERS1
Entity type gene
Source Source Link

Details

PrimaryID10715
RefseqGeneNG_012070
SymbolCERS1
Nameceramide synthase 1
Chromosome19
Location19p13.11
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-12-12
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsCERS1_HUMAN

GO terms

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GOName
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016410 N-acyltransferase activity
GO:0030148 sphingolipid biosynthetic process
GO:0035690 cellular response to drug
GO:0036146 cellular response to mycotoxin
GO:0043231 intracellular membrane-bounded organelle
GO:0046513 ceramide biosynthetic process
GO:0050291 sphingosine N-acyltransferase activity
GO:0051974 negative regulation of telomerase activity
GO:0071492 cellular response to UV-A
GO:0072721 cellular response to dithiothreitol

Diseases

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Disease IDSourceNameDescription
616230 OMIMEpilepsy, progressive myoclonic 8 (EPM8)A form of progressive myoclonic epilepsy, a clinically and genetically heterogeneous group of disorders defined by the combination of action and reflex myoclonus, other types of epileptic seizures, and progressive neurodegeneration and neurocognitive impairment. EPM8 is an autosomal recessive form characterized by myoclonus, generalized tonic-clonic seizures and moderate to severe cognitive impairment. The disease is caused by variants affecting the gene represented in this entry.