Entity Details

Primary name TADBP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13148
EntryNameTADBP_HUMAN
FullNameTAR DNA-binding protein 43
TaxID9606
Evidenceevidence at protein level
Length414
SequenceStatuscomplete
DateCreated2002-03-27
DateModified2021-06-02

Ontological Relatives

GenesTARDBP

GO terms

Show/Hide Table
GOName
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001933 negative regulation of protein phosphorylation
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005726 perichromatin fibrils
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010468 regulation of gene expression
GO:0010494 cytoplasmic stress granule
GO:0010629 negative regulation of gene expression
GO:0016607 nuclear speck
GO:0031647 regulation of protein stability
GO:0032024 positive regulation of insulin secretion
GO:0034976 response to endoplasmic reticulum stress
GO:0035061 interchromatin granule
GO:0042307 positive regulation of protein import into nucleus
GO:0042752 regulation of circadian rhythm
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043922 negative regulation by host of viral transcription
GO:0048511 rhythmic process
GO:0051726 regulation of cell cycle
GO:0061158 3'-UTR-mediated mRNA destabilization
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:0071765 nuclear inner membrane organization
GO:0097157 pre-mRNA intronic binding

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000504 RNA recognition motif domainDomainDomain
IPR012677 Nucleotide-binding alpha-beta plait domain superfamilyFamilyHomologous superfamily
IPR035979 RNA-binding domain superfamilyFamilyHomologous superfamily
IPR041105 TAR DNA-binding protein 43, N-terminalDomainDomain

Diseases

Show/Hide Table
Disease IDSourceNameDescription
612069 OMIMAmyotrophic lateral sclerosis 10 (ALS10)A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. The disease is caused by variants affecting the gene represented in this entry.

Interactions

239 interactions

InteractorPartnerSourcesPublicationsLink
TADBP_HUMANEXOSX_HUMANBioGRID, HPRD, IntAct15231747 details
TADBP_HUMANXRN2_HUMANBioGRID, HPRD, IntAct15231747 20020773 32814053 details
TADBP_HUMANNSF1C_HUMANBioGRID, HPRD, IntAct16169070 32814053 details
TADBP_HUMANMED19_HUMANIntAct15175163 32814053 details
TADBP_HUMANIRAK2_HUMANBioGRID, IntAct21903422 details
TADBP_HUMANSETB1_HUMANBioGRID, HPRD, IntAct16169070 details
TADBP_HUMANZHX1_HUMANBioGRID, HPRD, IntAct16169070 details
TADBP_HUMANTADBP_HUMANBioGRID, DIP, MINT19383787 19465477 20020773 21666678 22193716 23384725 26099433 26735904 29531287 29715546 31235914 details
TADBP_HUMANGBB2_HUMANBioGRID, IntAct28514442 32814053 details
TADBP_HUMANFUS_HUMANBioGRID, IntAct20720006 26334913 27615052 32814053 details
TADBP_HUMANTNR14_HUMANIntAct17353931 32814053 details
TADBP_HUMANTOB1_HUMANIntAct, UniProt18377426 32814053 details
TADBP_HUMANVSX2_HUMANIntAct32814053 details
TADBP_HUMANMATR3_HUMANBioGRID, IntAct20020773 29511296 29884807 32814053 details
TADBP_HUMANPTBP1_HUMANBioGRID, IntAct20020773 32814053 details
TADBP_HUMANOTUB1_HUMANBioGRID, IntAct26752685 32814053 details
TADBP_HUMANWWP2_HUMANIntAct32814053 details
TADBP_HUMANATF3_HUMANIntAct32814053 details
TADBP_HUMANDDX5_HUMANBioGRID, IntAct20020773 32814053 details
TADBP_HUMANMAT1_HUMANIntAct32814053 details
TADBP_HUMANVATB1_HUMANIntAct32814053 details
TADBP_HUMANVHL_HUMANBioGRID, IntAct26751167 32814053 details
TADBP_HUMANMYC_HUMANBioGRID, IntAct29467282 32814053 details
TADBP_HUMANTRI23_HUMANIntAct32814053 details
TADBP_HUMANATG7_HUMANIntAct32814053 details
TADBP_HUMANEIF3F_HUMANIntAct32814053 details
TADBP_HUMANOTX1_HUMANIntAct32814053 details
TADBP_HUMANRBMX_HUMANBioGRID, IntAct20020773 32814053 details
TADBP_HUMANRNF37_HUMANIntAct32814053 details
TADBP_HUMANIF2B3_HUMANIntAct32814053 details
TADBP_HUMANHNRH1_HUMANBioGRID, IntAct, MINT20020773 26760575 29725819 32814053 details
TADBP_HUMANANXA8_HUMANIntAct32814053 details
TADBP_HUMANEED_HUMANBioGRID, IntAct24457600 32814053 details
TADBP_HUMANKC1D_HUMANIntAct32814053 details
TADBP_HUMANHNRPC_HUMANBioGRID, IntAct20020773 32814053 details
TADBP_HUMANHNRPQ_HUMANBioGRID, IntAct20020773 22939629 32814053 details
TADBP_HUMANBAG6_HUMANIntAct32814053 details
TADBP_HUMANA4_HUMANBioGRID, IntAct21832049 32814053 details
TADBP_HUMANPRKN_HUMANBioGRID, IntAct24298989 28430587 32814053 32929329 details
TADBP_HUMANUBA7_HUMANIntAct32814053 details
TADBP_HUMANPSB8_HUMANIntAct32814053 details
TADBP_HUMANHNRDL_HUMANBioGRID, IntAct20020773 32814053 details
TADBP_HUMANHNRPR_HUMANBioGRID, IntAct20020773 22939629 32814053 details
TADBP_HUMANSOCS6_HUMANIntAct32814053 details
TADBP_HUMANIG2R_HUMANIntAct32814053 details
TADBP_HUMANDDX3X_HUMANBioGRID, IntAct20020773 32814053 details
TADBP_HUMANBIRC5_HUMANIntAct32814053 details
TADBP_HUMANEPHB2_HUMANIntAct32814053 details
TADBP_HUMANEXOC5_HUMANIntAct32814053 details
TADBP_HUMANIN35_HUMANIntAct32814053 details
TADBP_HUMANPSB4_HUMANIntAct32814053 details
TADBP_HUMANLSM8_HUMANIntAct32814053 details
TADBP_HUMANHNRPK_HUMANBioGRID, IntAct22939629 32814053 details
TADBP_HUMANAP2B1_HUMANIntAct32814053 details
TADBP_HUMANZBT25_HUMANIntAct32814053 details
TADBP_HUMANUBP2_HUMANIntAct32814053 details
TADBP_HUMANDCAF7_HUMANIntAct32814053 details
TADBP_HUMANOTU7B_HUMANIntAct32814053 details
TADBP_HUMANF117B_HUMANIntAct32814053 details
TADBP_HUMANDDI2_HUMANIntAct32814053 details
TADBP_HUMANPRP8_HUMANIntAct32814053 details
TADBP_HUMANSTABP_HUMANIntAct32814053 details
TADBP_HUMANBEX5_HUMANIntAct32814053 details
TADBP_HUMANLEG9C_HUMANIntAct32814053 details
TADBP_HUMANMOCS3_HUMANIntAct32814053 details
TADBP_HUMANZBT24_HUMANIntAct32814053 details
TADBP_HUMANKLH26_HUMANIntAct32814053 details
TADBP_HUMANDCAF8_HUMANIntAct32814053 details
TADBP_HUMANNVL_HUMANIntAct32814053 details
TADBP_HUMANKLH22_HUMANIntAct32814053 details
TADBP_HUMANCF141_HUMANIntAct32814053 details
TADBP_HUMANNDKM_HUMANIntAct32814053 details
TADBP_HUMANFA98C_HUMANIntAct32814053 details
TADBP_HUMANMK11_HUMANIntAct32814053 details
TADBP_HUMANELAV1_HUMANBioGRID, IntAct20020773 32814053 details
TADBP_HUMANILF3_HUMANBioGRID, IntAct20020773 32814053 details
TADBP_HUMANDSRAD_HUMANBioGRID, IntAct20020773 32814053 details
TADBP_HUMANARL16_HUMANIntAct32814053 details
TADBP_HUMANYBOX1_HUMANIntAct32814053 details
TADBP_HUMANTERF2_HUMANIntAct32814053 details
TADBP_HUMANHNRPU_HUMANBioGRID, IntAct20020773 32814053 details
TADBP_HUMANPRPS1_HUMANIntAct32814053 details
TADBP_HUMANMLC1_HUMANIntAct32814053 details
TADBP_HUMANRBM10_HUMANIntAct32814053 details
TADBP_HUMANIQEC1_HUMANIntAct32814053 details
TADBP_HUMANLONF2_HUMANIntAct32814053 details
TADBP_HUMANGABP1_HUMANIntAct32814053 details
TADBP_HUMANPPR21_HUMANIntAct32814053 details
TADBP_HUMANTASO2_HUMANIntAct32814053 details
TADBP_HUMANCLPP_HUMANIntAct32814053 details
TADBP_HUMANPZRN4_HUMANIntAct32814053 details
TADBP_HUMANESRP1_HUMANIntAct32814053 details
TADBP_HUMANCP100_HUMANIntAct32814053 details
TADBP_HUMANCBX2_HUMANIntAct32814053 details
TADBP_HUMANRBM46_HUMANIntAct32814053 details
TADBP_HUMANMAGC3_HUMANIntAct32814053 details
TADBP_HUMANSF3B3_HUMANIntAct32814053 details
TADBP_HUMANPSMD2_HUMANIntAct32814053 details
TADBP_HUMANKCD17_HUMANIntAct32814053 details
TADBP_HUMANLNX1_HUMANIntAct32814053 details
TADBP_HUMANCALI_HUMANIntAct32814053 details
TADBP_HUMANCBLB_HUMANIntAct32814053 details
TADBP_HUMANRNF10_HUMANBioGRID, IntAct20020773 32814053 details
TADBP_HUMANZSCA1_HUMANIntAct32814053 details
TADBP_HUMANUB2V1_HUMANIntAct32814053 details
TADBP_HUMANCDC16_HUMANIntAct32814053 details
TADBP_HUMANKLH36_HUMANIntAct32814053 details
TADBP_HUMANMPND_HUMANIntAct32814053 details
TADBP_HUMANMKRN3_HUMANIntAct32814053 details
TADBP_HUMANTHAP3_HUMANIntAct32814053 details
TADBP_HUMANRYBP_HUMANIntAct32814053 details
TADBP_HUMANRBBP4_HUMANIntAct32814053 details
TADBP_HUMANCELF1_HUMANBioGRID, IntAct20020773 29395067 32814053 details
TADBP_HUMANSIAH1_HUMANIntAct32814053 details
TADBP_HUMANAN13D_HUMANIntAct32814053 details
TADBP_HUMANID2_HUMANIntAct32814053 details
TADBP_HUMANDDX17_HUMANBioGRID, IntAct20020773 32814053 details
TADBP_HUMANTRI74_HUMANIntAct32814053 details
TADBP_HUMANKLH17_HUMANIntAct32814053 details
TADBP_HUMANPACS1_HUMANIntAct32814053 details
TADBP_HUMANHUMMR_HUMANIntAct32814053 details
TADBP_HUMANRN138_HUMANIntAct32814053 details
TADBP_HUMANDPF1_HUMANIntAct32814053 details
TADBP_HUMANSYMPK_HUMANIntAct32814053 details
TADBP_HUMANENKUR_HUMANIntAct32814053 details
TADBP_HUMANDPP9_HUMANIntAct32814053 details
TADBP_HUMANASB13_HUMANIntAct32814053 details
TADBP_HUMANJADE3_HUMANIntAct32814053 details
TADBP_HUMANBAHD1_HUMANIntAct32814053 details
TADBP_HUMANNUP43_HUMANIntAct32814053 details
TADBP_HUMANASB9_HUMANIntAct32814053 details
TADBP_HUMANRN183_HUMANIntAct32814053 details
TADBP_HUMANSPT22_HUMANIntAct32814053 details
TADBP_HUMANCTL5_HUMANIntAct32814053 details
TADBP_HUMANGTPB3_HUMANIntAct32814053 details
TADBP_HUMANWDR83_HUMANIntAct32814053 details
TADBP_HUMANCEP70_HUMANIntAct32814053 details
TADBP_HUMANHNRL1_HUMANBioGRID, IntAct20020773 32814053 details
TADBP_HUMANGMPPA_HUMANIntAct32814053 details
TADBP_HUMANVP37A_HUMANIntAct32814053 details
TADBP_HUMANLNX2_HUMANIntAct32814053 details
TADBP_HUMANKCD15_HUMANIntAct32814053 details
TADBP_HUMANZN366_HUMANIntAct32814053 details
TADBP_HUMANUBQLN_HUMANIntAct32814053 details
TADBP_HUMANRMD5B_HUMANIntAct32814053 details
TADBP_HUMANIF2B2_HUMANBioGRID, IntAct20020773 32814053 details
TADBP_HUMANMET27_HUMANIntAct32814053 details
TADBP_HUMANUBP48_HUMANIntAct32814053 details
TADBP_HUMANSMRD1_HUMANIntAct32814053 details
TADBP_HUMANGPSM3_HUMANIntAct32814053 details
TADBP_HUMANMIER1_HUMANIntAct32814053 details
TADBP_HUMANABTB1_HUMANIntAct32814053 details
TADBP_HUMANKRA92_HUMANIntAct32814053 details
TADBP_HUMANMTF2_HUMANIntAct32814053 details
TADBP_HUMANFAM9A_HUMANIntAct32814053 details
TADBP_HUMANTBX22_HUMANIntAct32814053 details
TADBP_HUMANKLH20_HUMANIntAct32814053 details
TADBP_HUMANCRLF3_HUMANIntAct32814053 details
TADBP_HUMANASIC4_HUMANIntAct32814053 details
TADBP_HUMANFBXL5_HUMANIntAct32814053 details
TADBP_HUMANHDAC6_HUMANBioGRID, IntAct19910924 23703321 32814053 details
TADBP_HUMANTRI69_HUMANIntAct32814053 details
TADBP_HUMANRN166_HUMANIntAct32814053 details
TADBP_HUMANCDC23_HUMANIntAct32814053 details
TADBP_HUMANKBTB4_HUMANIntAct32814053 details
TADBP_HUMANUBP13_HUMANIntAct32814053 details
TADBP_HUMANLMBL3_HUMANIntAct32814053 details
TADBP_HUMANPAR11_HUMANIntAct32814053 details
TADBP_HUMANDNJA3_HUMANIntAct32814053 details
TADBP_HUMANZN581_HUMANIntAct32814053 details
TADBP_HUMANBTBD1_HUMANIntAct32814053 details
TADBP_HUMANSPSB1_HUMANIntAct32814053 details
TADBP_HUMANRN112_HUMANIntAct32814053 details
TADBP_HUMANWDR61_HUMANIntAct32814053 details
TADBP_HUMANSQSTM_HUMANBioGRID18584184 22674379 details
TADBP_HUMANHOIL1_HUMANIntAct32814053 details
TADBP_HUMANFBX4_HUMANIntAct32814053 details
TADBP_HUMANWDR12_HUMANIntAct32814053 details
TADBP_HUMANSPAG8_HUMANIntAct32814053 details
TADBP_HUMANPCMD2_HUMANIntAct32814053 details
TADBP_HUMANPBX4_HUMANIntAct32814053 details
TADBP_HUMANMED6_HUMANBioGRID24825905 details
TADBP_HUMANKLH32_HUMANIntAct32814053 details
TADBP_HUMANRAD18_HUMANIntAct32814053 details
TADBP_HUMANASB3_HUMANIntAct32814053 details
TADBP_HUMANHES4_HUMANIntAct32814053 details
TADBP_HUMANCH048_HUMANIntAct32814053 details
TADBP_HUMANPATZ1_HUMANIntAct32814053 details
TADBP_HUMANUBQL1_HUMANBioGRID19112176 details
TADBP_HUMANTRI45_HUMANIntAct32814053 details
TADBP_HUMANCBLC_HUMANIntAct32814053 details
TADBP_HUMANMKRN2_HUMANIntAct32814053 details
TADBP_HUMANUBQL2_HUMANBioGRID23541532 details
TADBP_HUMANTRIM9_HUMANIntAct32814053 details
TADBP_HUMANKLF15_HUMANIntAct32814053 details
TADBP_HUMANLDH6B_HUMANIntAct32814053 details
TADBP_HUMANRACK1_HUMANBioGRID20020773 24825905 details
TADBP_HUMANDEAF1_HUMANIntAct32814053 details
TADBP_HUMANRNF14_HUMANIntAct32814053 details
TADBP_HUMANNACC1_HUMANBioGRID23022214 details
TADBP_HUMANRING2_HUMANBioGRID24825905 details
TADBP_HUMANRBM45_HUMANBioGRID24825905 26979993 details
TADBP_HUMANFBX7_HUMANBioGRID27503909 details
TADBP_HUMANSMUF1_HUMANIntAct32814053 details
TADBP_HUMANRMD5A_HUMANIntAct32814053 details
TADBP_HUMANTRIM8_HUMANIntAct32814053 details
TADBP_HUMANLSM6_HUMANBioGRID24825905 details
TADBP_HUMANUB2E3_HUMANBioGRID24825905 details
TADBP_HUMANUBP8_HUMANBioGRID24825905 details
TADBP_HUMANZFN2B_HUMANBioGRID25416956 details
TADBP_HUMANTIAR_HUMANIntAct, MINT22193716 29109149 details
TADBP_HUMANARF6_HUMANIntAct17353931 details
TADBP_HUMANHLAB_HUMANIntAct17353931 details
TADBP_HUMANPR15A_HUMANIntAct29109149 details
TADBP_HUMANROA2_HUMANBioGRID, DIP19383787 20020773 25678563 details
TADBP_HUMANATX2_HUMANBioGRID, DIP20740007 26344197 details
TADBP_HUMANTERA_HUMANBioGRID19237541 20020773 details
TADBP_HUMANHSP74_HUMANBioGRID20020773 20804554 26936937 details
TADBP_HUMANIMA3_HUMANUniProt26571498 details
TADBP_HUMANTF65_HUMANUniProt24690380 details
TADBP_HUMANPABP2_HUMANBioGRID20720006 details
TADBP_HUMANITA4_HUMANBioGRID22623428 details
TADBP_HUMANHS90A_HUMANBioGRID20804554 details
TADBP_HUMANSTAU1_HUMANBioGRID20020773 23125841 details
TADBP_HUMANARG28_HUMANBioGRID22941224 details
TADBP_HUMANPABP1_HUMANBioGRID20020773 details
TADBP_HUMANCUL2_HUMANBioGRID26751167 details
TADBP_HUMANPHB2_HUMANBioGRID29715546 details
TADBP_HUMANRNF4_HUMANBioGRID24882209 32521226 details
TADBP_HUMANPPIA_HUMANBioGRID25678563 details
TADBP_HUMANVDAC1_HUMANBioGRID29715546 details
TADBP_HUMANDNJB2_HUMANBioGRID26936937 details
TADBP_HUMANCCNF_HUMANBioGRID31577344 details
TADBP_HUMANRU17_HUMANBioGRID29802200 details
TADBP_HUMANRFOX3_HUMANBioGRID26334913 details
TADBP_HUMANAIRE_HUMANBioGRID27365398 details
TADBP_HUMANSFPQ_HUMANBioGRID26334913 details
TADBP_HUMANCTSL2_HUMANBioGRID26674342 details
TADBP_HUMANCDC37_HUMANBioGRID16611982 details