Entity Details

Primary name MP2K5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13163
EntryNameMP2K5_HUMAN
FullNameDual specificity mitogen-activated protein kinase kinase 5
TaxID9606
Evidenceevidence at protein level
Length448
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMAP2K5

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000187 obsolete activation of MAPK activity
GO:0004672 protein kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005819 spindle
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0007507 heart development
GO:0030307 positive regulation of cell growth
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032717 negative regulation of interleukin-8 production
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051247 positive regulation of protein metabolic process
GO:0060761 negative regulation of response to cytokine stimulus
GO:0070375 ERK5 cascade
GO:0071363 cellular response to growth factor stimulus
GO:0071499 cellular response to laminar fluid shear stress
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000270 PB1 domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR034851 Dual specificity mitogen-activated protein kinase kinase 5, PB1 domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

62 interactions

InteractorPartnerSourcesPublicationsLink
MP2K5_HUMANM3K3_HUMANBioGRID, IntAct11073940 12813044 14743216 16861740 19903815 24975362 25241761 28514442 details
MP2K5_HUMANMK07_HUMANBioGRID, IntAct24975362 28514442 32296183 7759517 details
MP2K5_HUMANGRB2_HUMANIntAct17474147 details
MP2K5_HUMANMRCKB_HUMANBioGRID, IntAct20936779 details
MP2K5_HUMAN1433Z_HUMANBioGRID, IntAct20936779 details
MP2K5_HUMANLNX2_HUMANBioGRID, IntAct, MINT21516116 29892012 31515488 details
MP2K5_HUMANXRCC6_HUMANBioGRID, IntAct21988832 details
MP2K5_HUMANRL28_HUMANBioGRID, IntAct21988832 details
MP2K5_HUMANM3K2_HUMANBioGRID, IntAct11073940 19903815 21988832 24975362 28514442 31980649 details
MP2K5_HUMANERR1_HUMANBioGRID, IntAct21988832 details
MP2K5_HUMANASGL1_HUMANBioGRID, MINT21900206 details
MP2K5_HUMANSTABP_HUMANBioGRID, IntAct16730941 details
MP2K5_HUMANZN426_HUMANBioGRID, IntAct32296183 details
MP2K5_HUMANSQSTM_HUMANBioGRID, IntAct12813044 19903815 31980649 32296183 34079125 details
MP2K5_HUMANGUCD1_HUMANBioGRID, IntAct32296183 details
MP2K5_HUMANDUS21_HUMANBioGRID, IntAct32296183 details
MP2K5_HUMANCC036_HUMANIntAct32296183 details
MP2K5_HUMANZN620_HUMANBioGRID, IntAct32296183 details
MP2K5_HUMANPFD5_HUMANBioGRID, IntAct32296183 details
MP2K5_HUMANKPCZ_HUMANBioGRID11158308 details
MP2K5_HUMANMP2K5_HUMANBioGRID28205554 31980649 7759517 details
MP2K5_HUMANPAR6A_HUMANBioGRID12813044 details
MP2K5_HUMANAKT1_HUMANBioGRID28205554 details
MP2K5_HUMANCCND2_HUMANBioGRID28205554 details
MP2K5_HUMANCD44_HUMANBioGRID28205554 details
MP2K5_HUMANCDK4_HUMANBioGRID28205554 details
MP2K5_HUMANCDK6_HUMANBioGRID28205554 details
MP2K5_HUMANCDN2A_HUMANBioGRID28205554 details
MP2K5_HUMANARF_HUMANBioGRID28205554 details
MP2K5_HUMANCDN2B_HUMANBioGRID28205554 details
MP2K5_HUMANEPHA2_HUMANBioGRID28205554 details
MP2K5_HUMANERBB2_HUMANBioGRID28205554 details
MP2K5_HUMANFGFR4_HUMANBioGRID28205554 details
MP2K5_HUMANGLIS2_HUMANBioGRID28205554 details
MP2K5_HUMANGRM1_HUMANBioGRID28205554 details
MP2K5_HUMANHGF_HUMANBioGRID28205554 details
MP2K5_HUMANLATS2_HUMANBioGRID28205554 details
MP2K5_HUMANMP2K3_HUMANBioGRID28205554 details
MP2K5_HUMANMET_HUMANBioGRID28205554 details
MP2K5_HUMANMYC_HUMANBioGRID28205554 details
MP2K5_HUMANMERL_HUMANBioGRID28205554 details
MP2K5_HUMANPGFRA_HUMANBioGRID28205554 details
MP2K5_HUMANRAF1_HUMANBioGRID28205554 details
MP2K5_HUMANSTK11_HUMANBioGRID28205554 details
MP2K5_HUMANTEAD2_HUMANBioGRID28205554 details
MP2K5_HUMANMP2K6_HUMANBioGRID28205554 details
MP2K5_HUMANARAF_HUMANBioGRID28205554 details
MP2K5_HUMANARNT_HUMANBioGRID28205554 details
MP2K5_HUMANBECN1_HUMANBioGRID28205554 details
MP2K5_HUMANCDN2C_HUMANBioGRID28205554 details
MP2K5_HUMANFZR1_HUMANBioGRID28205554 details
MP2K5_HUMANHIF1A_HUMANBioGRID28205554 details
MP2K5_HUMANMDM4_HUMANBioGRID28205554 details
MP2K5_HUMANTERT_HUMANBioGRID28205554 details
MP2K5_HUMANP53_HUMANBioGRID28205554 details
MP2K5_HUMANTSC1_HUMANBioGRID28205554 details
MP2K5_HUMANGSK3B_HUMANIntAct17353931 details
MP2K5_HUMANHS90B_HUMANBioGRID, IntAct22939624 31980649 details
MP2K5_HUMANHS90A_HUMANBioGRID, IntAct22939624 31980649 details
MP2K5_HUMANENOA_HUMANBioGRID15805119 details
MP2K5_HUMANKPCI_HUMANBioGRID12813044 details
MP2K5_HUMANGCH1_HUMANBioGRID19294699 details