Entity Details

Primary name STK3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13188
EntryNameSTK3_HUMAN
FullNameSerine/threonine-protein kinase 3
TaxID9606
Evidenceevidence at protein level
Length491
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesSTK3

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001841 neural tube formation
GO:0003157 endocardium development
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007417 central nervous system development
GO:0008285 negative regulation of cell population proliferation
GO:0031098 stress-activated protein kinase signaling cascade
GO:0032092 positive regulation of protein binding
GO:0032147 activation of protein kinase activity
GO:0032991 protein-containing complex
GO:0035329 hippo signaling
GO:0035556 intracellular signal transduction
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043539 protein serine/threonine kinase activator activity
GO:0045600 positive regulation of fat cell differentiation
GO:0046330 positive regulation of JNK cascade
GO:0046621 negative regulation of organ growth
GO:0050821 protein stabilization
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0060215 primitive hemopoiesis
GO:0060706 cell differentiation involved in embryonic placenta development
GO:0060800 regulation of cell differentiation involved in embryonic placenta development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097284 hepatocyte apoptotic process
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011524 SARAH domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR024205 Mst1 SARAH domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

61 interactions

InteractorPartnerSourcesPublicationsLink
STK3_HUMANRASF5_HUMANBioGRID, DIP, IntAct, MINT, Molecular Connections16892067 20562859 20920251 21988832 23455922 23972470 24255178 24366813 24981860 details
STK3_HUMANSAV1_HUMANBioGRID, HPRD, IntAct, MINT, Molecular Connections15688006 16930133 17379520 20562859 20920251 21988832 23455922 24255178 24366813 24981860 26186194 28514442 32296183 details
STK3_HUMANRASF1_HUMANBioGRID, IntAct, MINT, Molecular Connections14729613 17379520 17598981 17889669 18347058 20086174 20920251 23455922 24255178 24366813 24981860 26186194 28205554 28514442 32296183 details
STK3_HUMANRASF2_HUMANBioGRID, IntAct, MINT, Molecular Connections20562859 20920251 23455922 24255178 24366813 24981860 25416956 26186194 28514442 31515488 32296183 details
STK3_HUMANRASF3_HUMANBioGRID, IntAct, Molecular Connections20920251 23455922 24255178 24366813 details
STK3_HUMANRASF4_HUMANBioGRID, IntAct, Molecular Connections20920251 23455922 24255178 24366813 25416956 32296183 details
STK3_HUMANRASF6_HUMANBioGRID, IntAct, Molecular Connections19797269 20920251 24366813 26186194 28514442 details
STK3_HUMANSTK4_HUMANBioGRID, IntAct, MINT, Molecular Connections20562859 20920251 23386615 23455922 24255178 24366813 24981860 26344197 28205554 details
STK3_HUMANGBRAP_HUMANBioGRID, IntAct20562859 31857374 details
STK3_HUMANGBRL1_HUMANBioGRID, IntAct20562859 31857374 details
STK3_HUMANGBRL2_HUMANIntAct20562859 details
STK3_HUMANMLP3B_HUMANBioGRID, IntAct20562859 31006538 31857374 details
STK3_HUMANMLP3C_HUMANBioGRID, IntAct20562859 31857374 details
STK3_HUMANSTK3_HUMANBioGRID, DIP, HPRD, IntAct12554736 15618521 18082144 20086174 20562859 23972470 28205554 details
STK3_HUMANPLK1_HUMANBioGRID, IntAct20562859 24255178 27566175 details
STK3_HUMANA1AG2_HUMANBioGRID, IntAct21988832 details
STK3_HUMANPEX19_HUMANBioGRID, IntAct21988832 details
STK3_HUMANCPNE1_HUMANBioGRID, IntAct21988832 details
STK3_HUMANCH10_HUMANBioGRID, IntAct21988832 details
STK3_HUMANST2A1_HUMANBioGRID, IntAct21988832 details
STK3_HUMANZ3H7A_HUMANBioGRID, IntAct21988832 details
STK3_HUMANDDAH2_HUMANBioGRID, MINT21900206 details
STK3_HUMANGBP2_HUMANBioGRID, MINT21900206 details
STK3_HUMANFUBP2_HUMANBioGRID, MINT21900206 details
STK3_HUMANEM55_HUMANBioGRID, MINT21900206 details
STK3_HUMANPHAX_HUMANBioGRID, MINT21900206 details
STK3_HUMANSYQ_HUMANBioGRID, MINT21900206 details
STK3_HUMANSLMAP_HUMANBioGRID, IntAct24255178 25416956 details
STK3_HUMANMOB1A_HUMANBioGRID, DIP, IntAct18362890 23972470 24255178 31941533 details
STK3_HUMANMOB1B_HUMANBioGRID, IntAct19919647 24255178 32296183 details
STK3_HUMANPHOCN_HUMANBioGRID, IntAct19797269 24255178 details
STK3_HUMANTFPT_HUMANBioGRID, IntAct25416956 32296183 details
STK3_HUMANTRAF1_HUMANBioGRID, IntAct25416956 32296183 details
STK3_HUMANFAM9B_HUMANBioGRID, IntAct25416956 details
STK3_HUMANDCE1_HUMANBioGRID, IntAct25416956 details
STK3_HUMANPKHF2_HUMANIntAct32296183 details
STK3_HUMANMOB3B_HUMANBioGRID, IntAct32296183 details
STK3_HUMANSNIP1_HUMANBioGRID, IntAct32296183 details
STK3_HUMANRAF1_HUMANBioGRID, DIP, HPRD15618521 17889669 20086174 20212043 24929361 details
STK3_HUMANJPH3_HUMANIntAct32814053 details
STK3_HUMANLATS1_HUMANBioGRID15688006 17379520 19962312 22195963 details
STK3_HUMANMBP_HUMANBioGRID20212043 details
STK3_HUMANLATS2_HUMANBioGRID, HPRD15688006 19919647 24255178 26898830 details
STK3_HUMANLRRK2_HUMANBioGRID20949042 details
STK3_HUMAN4EBP1_HUMANBioGRID20090955 details
STK3_HUMANAKT1_HUMANBioGRID20086174 20231902 details
STK3_HUMANGMCL1_HUMANBioGRID25416956 details
STK3_HUMANCDK1_HUMANBioGRID27566175 details
STK3_HUMANKEAP1_HUMANBioGRID30765703 details
STK3_HUMANMARK2_HUMANBioGRID31080060 details
STK3_HUMANOGT1_HUMANBioGRID32994395 details
STK3_HUMANCASP3_HUMANBioGRID, HPRD, IntAct11278283 25241761 details
STK3_HUMANZDH17_HUMANIntAct24705354 details
STK3_HUMANPRDX1_HUMANIntAct23386615 details
STK3_HUMANKIF3B_HUMANBioGRID, IntAct27173435 unassigned1312 details
STK3_HUMANCNKR1_HUMANBioGRID, HPRD15075335 details
STK3_HUMANNRDC_HUMANBioGRID18362890 details
STK3_HUMANPTN14_HUMANBioGRID22948661 27432908 details
STK3_HUMANTAZ_HUMANBioGRID22078877 details
STK3_HUMANCT2NL_HUMANBioGRID24255178 details
STK3_HUMANFBW1B_HUMANBioGRID25332235 25900982 details