Entity Details

Primary name 2A5G_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13362
EntryName2A5G_HUMAN
FullNameSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
TaxID9606
Evidenceevidence at protein level
Length524
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesPPP2R5C

GO terms

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GOName
GO:0000159 protein phosphatase type 2A complex
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006470 protein dephosphorylation
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007165 signal transduction
GO:0008285 negative regulation of cell population proliferation
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0019888 protein phosphatase regulator activity
GO:0031952 regulation of protein autophosphorylation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051898 negative regulation of protein kinase B signaling
GO:0072542 protein phosphatase activator activity
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR002554 Protein phosphatase 2A, regulatory B subunit, B56FamilyFamily
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02506 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic AcidDrugbanksmall molecule
DB06905 (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acidDrugbanksmall molecule

Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
2A5G_HUMANPP2AA_HUMANBioGRID, DIP, HPRD, I2D, IntAct, MINT10675325 11929880 1328865 15380617 16456541 18782753 19156129 19915589 21460856 26344197 27880917 28330616 7592815 8703017 details
2A5G_HUMANMK01_HUMANBioGRID, MINT16456541 details
2A5G_HUMAN2AAA_HUMANBioGRID, DIP, I2D, IntAct, MINT15380617 17245430 17529992 18782753 19156129 19915589 21460856 23443559 26344197 26496610 27173435 28330616 8617797 unassigned1312 details
2A5G_HUMANCHK2_HUMANBioGRID, HPRD, IntAct15380617 23178491 details
2A5G_HUMANRAF1_HUMANMINT16239230 details
2A5G_HUMANEP300_HUMANBioGRID, HPRD, MINT15632055 details
2A5G_HUMANDZIP1_HUMANMINT21878643 details
2A5G_HUMANATM_HUMANBioGRID, I2D21460856 details
2A5G_HUMANPP1B_HUMANBioGRID, DIP25487150 details
2A5G_HUMANPP1G_HUMANBioGRID, DIP25487150 details
2A5G_HUMANPP1A_HUMANBioGRID, DIP25487150 details
2A5G_HUMANMBP_HUMANBioGRID15380617 details
2A5G_HUMANA4_HUMANBioGRID21832049 details
2A5G_HUMANBRCA1_HUMANBioGRID22990118 details
2A5G_HUMANPAXI1_HUMANBioGRID22990118 details
2A5G_HUMANOGT1_HUMANBioGRID32994395 details
2A5G_HUMANIEX1_HUMANBioGRID, MINT16456541 details
2A5G_HUMAN2AAB_HUMANBioGRID, HPRD, IntAct, MINT11929880 16456541 17540176 26344197 8703017 details
2A5G_HUMANP53_HUMANBioGRID, I2D, IntAct, MINT17245430 21460856 25241761 details
2A5G_HUMANMDM2_HUMANBioGRID, I2D21460856 details
2A5G_HUMANAXIN1_HUMANbhf-ucl, HPRD10698523 17510365 details
2A5G_HUMANCCNG1_HUMANBioGRID, IntAct21460856 26186194 28514442 details
2A5G_HUMANCCNG2_HUMANBioGRID11956189 28514442 details
2A5G_HUMAN2A5A_HUMANBioGRID11929880 details
2A5G_HUMANTBC3C_HUMANBioGRID22348058 details
2A5G_HUMANTBC3A_HUMANBioGRID22348058 details
2A5G_HUMANKPCD_HUMANHPRD11959144 details
2A5G_HUMANPAXI_HUMANHPRD10675325 details
2A5G_HUMANSGO1_HUMANHPRD16541024 16541025 details