Entity Details

Primary name ORC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13415
EntryNameORC1_HUMAN
FullNameOrigin recognition complex subunit 1
TaxID9606
Evidenceevidence at protein level
Length861
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesORC1

GO terms

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GOName
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000781 chromosome, telomeric region
GO:0000808 origin recognition complex
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005664 nuclear origin of replication recognition complex
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0016887 ATP hydrolysis activity
GO:0033314 mitotic DNA replication checkpoint signaling
GO:0036388 pre-replicative complex assembly
GO:0046872 metal ion binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001025 Bromo adjacent homology (BAH) domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR003959 ATPase, AAA-type, coreDomainDomain
IPR015163 Cdc6, C-terminalDomainDomain
IPR020793 Origin recognition complex, subunit 1FamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR041083 AAA lid domainDomainDomain
IPR043151 Bromo adjacent homology (BAH) domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
ORC1_HUMANCDC6_HUMANBioGRID, HPRD, IntAct12614612 12912926 15232106 9566895 details
ORC1_HUMANCDC5L_HUMANBioGRID, HPRD, IntAct15232106 details
ORC1_HUMANMCM5_HUMANBioGRID, HPRD, IntAct15232106 details
ORC1_HUMANCDT1_HUMANBioGRID, HPRD, IntAct15232106 details
ORC1_HUMANORC5_HUMANBioGRID, DIP, HPRD, IntAct12614612 15232106 16549788 17716973 22398447 26496610 31160578 details
ORC1_HUMANORC2_HUMANBioGRID, DIP, HPRD, IntAct11323433 11779870 11931757 12614612 15232106 16549788 17716973 20850016 22398447 26496610 31160578 details
ORC1_HUMANORC3_HUMANBioGRID, DIP, HPRD, IntAct15232106 16549788 17716973 22398447 26496610 31160578 details
ORC1_HUMANCDK2_HUMANBioGRID, HPRD, IntAct11931757 31160578 details
ORC1_HUMANSKP2_HUMANBioGRID, HPRD, IntAct11931757 31160578 details
ORC1_HUMANTERF2_HUMANBioGRID, MINT16799465 18761675 31160578 details
ORC1_HUMANABL1_HUMANIntAct17474147 details
ORC1_HUMANFYN_HUMANIntAct17474147 details
ORC1_HUMANTS101_HUMANIntAct19549727 details
ORC1_HUMANORC4_HUMANBioGRID, DIP, IntAct12614612 16549788 17716973 26496610 31160578 details
ORC1_HUMANGG6L9_HUMANBioGRID, IntAct32296183 details
ORC1_HUMANHMGA1_HUMANDIP18234858 details
ORC1_HUMANCBX5_HUMANDIP20689044 details
ORC1_HUMANMCM2_HUMANBioGRID, HPRD12614612 details
ORC1_HUMANMCM7_HUMANBioGRID, HPRD12614612 details
ORC1_HUMANCDC7_HUMANBioGRID, HPRD12614612 details
ORC1_HUMANMCM4_HUMANBioGRID12614612 details
ORC1_HUMANMCM6_HUMANBioGRID12614612 details
ORC1_HUMANDBF4A_HUMANBioGRID12614612 details
ORC1_HUMANCDC45_HUMANBioGRID12614612 details
ORC1_HUMANRFA2_HUMANBioGRID12614612 details
ORC1_HUMANKAT7_HUMANBioGRID, HPRD10438470 details
ORC1_HUMANGOGA2_HUMANBioGRID25416956 details
ORC1_HUMANRB_HUMANBioGRID21085491 details
ORC1_HUMANCCNA2_HUMANBioGRID, IntAct11931757 26186194 26496610 28514442 31160578 details
ORC1_HUMANUBB_HUMANIntAct11931757 details
ORC1_HUMANLRWD1_HUMANBioGRID, IntAct26496610 31160578 details
ORC1_HUMANXRCC5_HUMANBioGRID12393188 31160578 details
ORC1_HUMANMGMT_HUMANBioGRID16226712 details
ORC1_HUMANOBI1_HUMANBioGRID31160578 details
ORC1_HUMANXPO1_HUMANHPRD11716535 details