Entity Details

Primary name RIPK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13546
EntryNameRIPK1_HUMAN
FullNameReceptor-interacting serine/threonine-protein kinase 1
TaxID9606
Evidenceevidence at protein level
Length671
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesRIPK1

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004706 JUN kinase kinase kinase activity
GO:0005123 death receptor binding
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 inflammatory response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007257 obsolete activation of JUN kinase activity
GO:0008219 cell death
GO:0010008 endosome membrane
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0010940 positive regulation of necrotic cell death
GO:0016579 protein deubiquitination
GO:0019054 modulation by virus of host cellular process
GO:0031264 death-inducing signaling complex
GO:0031625 ubiquitin protein ligase binding
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034612 response to tumor necrosis factor
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0036289 peptidyl-serine autophosphorylation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043068 positive regulation of programmed cell death
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043235 receptor complex
GO:0044257 cellular protein catabolic process
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045651 positive regulation of macrophage differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0050729 positive regulation of inflammatory response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060544 regulation of necroptotic process
GO:0060545 positive regulation of necroptotic process
GO:0060546 negative regulation of necroptotic process
GO:0062099 negative regulation of programmed necrotic cell death
GO:0070105 positive regulation of interleukin-6-mediated signaling pathway
GO:0070231 T cell apoptotic process
GO:0070266 necroptotic process
GO:0070301 cellular response to hydrogen peroxide
GO:0070513 death domain binding
GO:0070926 regulation of ATP:ADP antiporter activity
GO:0071356 cellular response to tumor necrosis factor
GO:0071550 death-inducing signaling complex assembly
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097300 programmed necrotic cell death
GO:0097342 ripoptosome
GO:0097343 ripoptosome assembly
GO:0097527 necroptotic signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1905206 positive regulation of hydrogen peroxide-induced cell death
GO:1990000 amyloid fibril formation
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR025735 RHIM domainDomainDomain
IPR037934 RIP1, Death domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

107 interactions

InteractorPartnerSourcesPublicationsLink
RIPK1_HUMANNEMO_HUMANBioGRID, HPRD, I2D, InnateDB, IntAct, MINT10755617 10880512 10980203 11262391 14653779 16543241 16547522 16603398 17702576 18029035 18212736 19373245 21113135 21383699 21458669 21606198 22099304 23104095 23746843 24735611 26740240 26802121 26865630 27929056 28249776 30561431 31502302 32024692 details
RIPK1_HUMANTRAF3_HUMANBioGRID, HPRD, IntAct, MINT32296183 8612133 details
RIPK1_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11181075 11479302 16291755 16603398 19815541 20577214 21282461 21810480 23007157 23972990 24434549 24735611 25416956 25716317 25882049 27768232 29352166 30561431 31502302 32296183 8612133 8702708 9020361 details
RIPK1_HUMANTRAF1_HUMANBioGRID, HPRD, IntAct, MINT19287455 25416956 32296183 8612133 details
RIPK1_HUMANTRADD_HUMANBioGRID, HPRD, IntAct, MINT16603398 21724995 23429285 24735611 27768232 30561431 8612133 details
RIPK1_HUMANTRI38_HUMANHPRD, MINT11854271 details
RIPK1_HUMANRIPK1_HUMANBioGRID, DIP, HPRD, IntAct14743216 15001576 15175328 22817896 23473668 25416956 27045108 31980649 32296183 details
RIPK1_HUMANTNFA_HUMANBioGRID, DIP, InnateDB, IntAct, MINT12753742 12887920 16603398 20005846 21331077 21620750 22028622 22099304 22675546 23032187 23104095 23815148 23955153 24726327 24980434 25911380 26670046 27307491 27458237 27545878 27560715 30420664 31898971 details
RIPK1_HUMANCASP8_HUMANBioGRID, DIP, HPRD, IntAct, MINT10521396 11002417 12215447 12884866 12887920 17047155 18485876 18570872 19060883 19373245 19524512 19524513 19773432 20825417 21282461 21458669 21525013 21737329 21737330 22173242 22179575 22274400 22585859 22864571 23429285 23955153 23972990 24098568 24577083 25911380 25939870 26733177 26972597 27552911 27810922 29021293 29274253 29431638 33052227 details
RIPK1_HUMANTNR6_HUMANBioGRID, HPRD, IntAct7538908 9740801 details
RIPK1_HUMANTNR1A_HUMANBioGRID, HPRD, IntAct, UniProt11002422 15258597 16115877 16611992 16968706 18022363 18450452 18621737 18724939 18939944 18949366 19524513 19773432 19781631 19815541 20448643 20825417 21113135 21331078 21737329 22179575 22733818 22817896 22848449 23429285 24098568 24130170 24758719 25388546 25681446 26802121 27321185 27552911 27591049 28388439 28514442 28817177 29431638 30420664 31406107 8612133 8985253 details
RIPK1_HUMANKC1A_HUMANUniProt18067272 details
RIPK1_HUMANRIPK3_HUMANBioGRID, HPIDb, HPRD, IntAct10339433 19524512 19524513 21903422 22265413 22265414 22817896 22864571 23744296 24098568 25882049 26319693 26559832 26786097 29352166 29497034 29883609 30420664 31358971 details
RIPK1_HUMANFADD_HUMANBioGRID, HPRD, IntAct11002422 11854271 19373245 19524513 21052097 21183682 21458669 21525013 21620750 21737329 22848449 22864571 23744296 23972990 24098568 24577083 26186194 26733177 26865630 26972597 27560715 29497034 30561431 32024820 32296183 details
RIPK1_HUMANMRCKB_HUMANBioGRID, IntAct20936779 details
RIPK1_HUMANNUMBL_HUMANBioGRID, IntAct21988832 details
RIPK1_HUMANBIRC2_HUMANBioGRID, IntAct18570872 19854138 21113135 21931591 23972990 26612615 27197231 29021293 29955050 30561431 details
RIPK1_HUMANXIAP_HUMANBioGRID, IntAct21931591 29955050 details
RIPK1_HUMANBIRC3_HUMANBioGRID, IntAct16547522 18570872 21113135 21931591 23972990 details
RIPK1_HUMANZBP1_HUMANIntAct22817896 details
RIPK1_HUMANDAXX_HUMANMINT23260419 details
RIPK1_HUMANTNAP3_HUMANBioGRID, HPRD, IntAct15258597 18246070 19131965 22585859 29274253 30561431 32015333 details
RIPK1_HUMANCRADD_HUMANBioGRID, HPRD8985253 9044836 details
RIPK1_HUMANRN216_HUMANBioGRID, HPRD11854271 16968706 27995769 details
RIPK1_HUMANSQSTM_HUMANBioGRID, HPRD10356400 26416459 details
RIPK1_HUMANPELI1_HUMANBioGRID19734906 33052227 details
RIPK1_HUMANOPTN_HUMANBioGRID17702576 21408173 22675546 27552911 details
RIPK1_HUMANKHDR1_HUMANBioGRID21620750 details
RIPK1_HUMANUBP2_HUMANBioGRID22179575 22659130 details
RIPK1_HUMANIKKB_HUMANBioGRID10980203 21606198 details
RIPK1_HUMANUBE2N_HUMANBioGRID18029035 details
RIPK1_HUMANOTU1_HUMANBioGRID23827681 details
RIPK1_HUMANOTUD1_HUMANBioGRID23827681 details
RIPK1_HUMANRFFL_HUMANBioGRID18450452 details
RIPK1_HUMANPRKN_HUMANBioGRID29955050 details
RIPK1_HUMANUBP20_HUMANBioGRID30354204 details
RIPK1_HUMANTBK1_HUMANBioGRID30420664 details
RIPK1_HUMANIKKE_HUMANBioGRID30420664 details
RIPK1_HUMANHS71L_HUMANIntAct14743216 details
RIPK1_HUMANBIP_HUMANIntAct14743216 details
RIPK1_HUMANHSP7C_HUMANIntAct14743216 details
RIPK1_HUMANADT2_HUMANIntAct14743216 details
RIPK1_HUMANGRP75_HUMANIntAct14743216 details
RIPK1_HUMANRL23_HUMANIntAct14743216 details
RIPK1_HUMANDNJA1_HUMANIntAct14743216 details
RIPK1_HUMANPYR1_HUMANIntAct14743216 details
RIPK1_HUMANACTG_HUMANIntAct14743216 details
RIPK1_HUMANTIM50_HUMANIntAct14743216 details
RIPK1_HUMANRCN2_HUMANIntAct14743216 details
RIPK1_HUMANTBB5_HUMANIntAct14743216 details
RIPK1_HUMANTBB4A_HUMANIntAct14743216 details
RIPK1_HUMANHS90A_HUMANBioGRID, HPRD, IntAct10744744 14743216 16968706 22939624 details
RIPK1_HUMANTBA3C_HUMANIntAct14743216 details
RIPK1_HUMANTBA3D_HUMANIntAct14743216 details
RIPK1_HUMANHS90B_HUMANIntAct14743216 22939624 details
RIPK1_HUMANPIDD1_HUMANBioGRID, MINT16360037 17159900 details
RIPK1_HUMANCCD50_HUMANBioGRID, HPRD, IntAct18029035 1802935 details
RIPK1_HUMANANXA1_HUMANBioGRID, I2D21383699 29021293 details
RIPK1_HUMANCFLAR_HUMANBioGRID, HPRD, IntAct10837247 11002417 17047155 21737330 26972597 details
RIPK1_HUMANCASPA_HUMANBioGRID, IntAct11002417 12884866 details
RIPK1_HUMANUBP4_HUMANBioGRID, MINT21331078 23313255 details
RIPK1_HUMANLRRK2_HUMANBioGRID, IntAct19176810 details
RIPK1_HUMANCDC37_HUMANIntAct25036637 details
RIPK1_HUMANASC_HUMANBioGRID, IntAct25402006 details
RIPK1_HUMANCARD6_HUMANDIP16418290 details
RIPK1_HUMANTCAM1_HUMANBioGRID, HPRD15064760 19734906 25736436 33052227 details
RIPK1_HUMANTP4AP_HUMANBioGRID, HPRD14585990 details
RIPK1_HUMANTR10B_HUMANBioGRID, HPRD22585859 32313199 9430227 details
RIPK1_HUMANTRAF5_HUMANBioGRID, HPRD11479302 29955050 details
RIPK1_HUMANEGFR_HUMANBioGRID, HPRD11116146 details
RIPK1_HUMANM3K14_HUMANBioGRID, HPRD11116146 details
RIPK1_HUMANRNF11_HUMANBioGRID, HPRD19131965 details
RIPK1_HUMANTAXB1_HUMANBioGRID, HPRD18246070 19131965 details
RIPK1_HUMANITCH_HUMANBioGRID, HPRD19131965 details
RIPK1_HUMANM3K7_HUMANBioGRID16543241 18570872 21606198 24434549 details
RIPK1_HUMANTAB2_HUMANBioGRID15327770 16603398 18299187 29955050 details
RIPK1_HUMANCYLD_HUMANBioGRID17981138 21408173 22848449 28900035 details
RIPK1_HUMANUBP21_HUMANBioGRID19910467 details
RIPK1_HUMANTNR25_HUMANBioGRID21421854 details
RIPK1_HUMANNOD2_HUMANBioGRID22607974 details
RIPK1_HUMANRIPK2_HUMANBioGRID22607974 details
RIPK1_HUMANHOIL1_HUMANBioGRID17449468 29955050 details
RIPK1_HUMANTLR3_HUMANBioGRID16115877 27810922 details
RIPK1_HUMANCLIP3_HUMANBioGRID22297296 details
RIPK1_HUMANM3K3_HUMANBioGRID, HPRD11429546 details
RIPK1_HUMANDAB2P_HUMANBioGRID15310755 17389591 details
RIPK1_HUMANTNR1B_HUMANBioGRID19287455 details
RIPK1_HUMANIKKA_HUMANBioGRID10980203 29955050 details
RIPK1_HUMANTNF10_HUMANBioGRID19432816 22585859 details
RIPK1_HUMANM3K8_HUMANBioGRID, HPRD16291755 details
RIPK1_HUMANUBC_HUMANBioGRID25423073 25715336 26017671 details
RIPK1_HUMANEGLN3_HUMANBioGRID26612615 26972000 details
RIPK1_HUMANRNF31_HUMANBioGRID26670046 29955050 details
RIPK1_HUMANERN1_HUMANBioGRID25476903 details
RIPK1_HUMANTRI27_HUMANBioGRID24144979 details
RIPK1_HUMANMLKL_HUMANBioGRID27560715 details
RIPK1_HUMANXAF1_HUMANBioGRID27768232 details
RIPK1_HUMANWDR48_HUMANBioGRID29138248 details
RIPK1_HUMANUBP1_HUMANBioGRID29138248 details
RIPK1_HUMANANGL8_HUMANBioGRID29255244 details
RIPK1_HUMANCBL_HUMANBioGRID29891719 details
RIPK1_HUMANATG5_HUMANBioGRID23744296 details
RIPK1_HUMANUBP15_HUMANBioGRID31903660 details
RIPK1_HUMANKPCZ_HUMANBioGRID32354117 details
RIPK1_HUMANTR10A_HUMANHPRD9430227 details
RIPK1_HUMANZFAN5_HUMANHPRD14754897 details
RIPK1_HUMANNFKB1_HUMANHPRD16291755 details