Entity Details

Primary name DEFA1
Entity type gene
Source Source Link

Details

PrimaryID1667
RefseqGene
SymbolDEFA1
Namedefensin alpha 1
Chromosome8
Location8p23.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-06
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsDEF1_HUMAN

GO terms

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GOName
GO:0002227 innate immune response in mucosa
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005796 Golgi lumen
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0010818 T cell chemotaxis
GO:0019730 antimicrobial humoral response
GO:0019731 antibacterial humoral response
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0031640 killing of cells of other organism
GO:0035578 azurophil granule lumen
GO:0042832 defense response to protozoan
GO:0043312 neutrophil degranulation
GO:0044657 pore formation in membrane of other organism during symbiotic interaction
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0050832 defense response to fungus
GO:0051607 defense response to virus
GO:0051673 membrane disruption in other organism
GO:0051873 killing by host of symbiont cells
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0071222 cellular response to lipopolysaccharide

Diseases

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Interactions

91 interactions

InteractorPartnerSourcesPublicationsLink
DEFA1PFDN1HPRD, IntAct16169070 details
DEFA1GSK3BBioGRID, MINT21900206 details
DEFA1ZNF16UniProt21874239 details
DEFA1UBQLN2BioGRID, IntAct32296183 details
DEFA1RBBP8BioGRID26387952 details
DEFA1DEFA3HPRD2006422 2997278 4056036 details
DEFA1C1QBHPRD9444979 details
DEFA1SERPINF2HPRD7873202 details
DEFA1LOXL2BioGRID, IntAct28514442 details
DEFA1PLXNA1BioGRID, IntAct28514442 details
DEFA1MOXD1BioGRID, IntAct28514442 details
DEFA1LIFRBioGRID, IntAct28514442 details
DEFA1BCHEBioGRID, IntAct28514442 details
DEFA1COCHBioGRID, IntAct28514442 details
DEFA1LRP12BioGRID, IntAct28514442 details
DEFA1NOTCH3BioGRID, IntAct28514442 details
DEFA1CEMIP2BioGRID, IntAct28514442 details
DEFA1CTSFBioGRID, IntAct28514442 details
DEFA1ERAP1BioGRID, IntAct28514442 details
DEFA1CACNA2D2BioGRID, IntAct28514442 details
DEFA1SMOC1BioGRID, IntAct28514442 details
DEFA1EDEM3BioGRID, IntAct28514442 details
DEFA1CNTNAP3BioGRID, IntAct28514442 details
DEFA1LRFN3BioGRID, IntAct28514442 details
DEFA1MCMBPBioGRID, IntAct28514442 details
DEFA1CNPY3BioGRID, IntAct28514442 details
DEFA1PRADC1BioGRID, IntAct28514442 details
DEFA1LGMNBioGRID, IntAct28514442 details
DEFA1TTC17BioGRID, IntAct28514442 details
DEFA1PXDNBioGRID, IntAct28514442 details
DEFA1TMEM131BioGRID, IntAct28514442 details
DEFA1SCARB1BioGRID, IntAct28514442 details
DEFA1SULF2BioGRID, IntAct28514442 details
DEFA1CILP2BioGRID, IntAct28514442 details
DEFA1UBE3DBioGRID, IntAct28514442 details
DEFA1ARSKBioGRID, IntAct28514442 details
DEFA1SUSD1BioGRID, IntAct28514442 details
DEFA1ABHD17BBioGRID, IntAct28514442 details
DEFA1TMEM67BioGRID, IntAct28514442 details
DEFA1TKFCBioGRID, IntAct28514442 details
DEFA1TMEM132ABioGRID, IntAct28514442 details
DEFA1LAMA3BioGRID, IntAct28514442 details
DEFA1NPTX1BioGRID, IntAct28514442 details
DEFA1NID2BioGRID, IntAct28514442 details
DEFA1ITGA7BioGRID, IntAct28514442 details
DEFA1FSTL1BioGRID, IntAct28514442 details
DEFA1PPP3CABioGRID, IntAct28514442 details
DEFA1TJP1BioGRID, IntAct28514442 details
DEFA1COL14A1BioGRID, IntAct28514442 details
DEFA1TGFBR3BioGRID, IntAct28514442 details
DEFA1CTBSBioGRID, IntAct28514442 details
DEFA1PPP3R1BioGRID, IntAct28514442 details
DEFA1NPC2BioGRID, IntAct28514442 details
DEFA1LAMB2BioGRID, IntAct28514442 details
DEFA1CACNA2D1BioGRID, IntAct28514442 details
DEFA1MAN2A2BioGRID, IntAct28514442 details
DEFA1PPP3CCBioGRID, IntAct28514442 details
DEFA1WNT5ABioGRID, IntAct28514442 details
DEFA1COL18A1BioGRID, IntAct28514442 details
DEFA1TIMP3BioGRID, IntAct28514442 details
DEFA1GALNSBioGRID, IntAct28514442 details
DEFA1CHRNA5BioGRID, IntAct28514442 details
DEFA1GRNBioGRID, IntAct28514442 details
DEFA1FBLN1BioGRID, IntAct28514442 details
DEFA1IGFBP2BioGRID, IntAct28514442 details
DEFA1PPP3CBBioGRID, IntAct28514442 details
DEFA1ARSBBioGRID, IntAct28514442 details
DEFA1EEF2BioGRID, IntAct28514442 details
DEFA1BMP1BioGRID, IntAct28514442 details
DEFA1COL6A1BioGRID, IntAct28514442 details
DEFA1LAMB1BioGRID, IntAct28514442 details
DEFA1ITGAVBioGRID, IntAct28514442 details
DEFA1TGFB1BioGRID, IntAct28514442 details
DEFA1LDLRBioGRID, IntAct28514442 details
DEFA1PLATBioGRID, IntAct28514442 details
DEFA1EGFRBioGRID, IntAct28514442 details
DEFA1NXPH4BioGRID, IntAct28514442 details
DEFA1SLIT2BioGRID, IntAct28514442 details
DEFA1CPDBioGRID, IntAct28514442 details
DEFA1IGSF3BioGRID, IntAct28514442 details
DEFA1PLXNA2BioGRID, IntAct28514442 details
DEFA1CTSVBioGRID, IntAct28514442 details
DEFA1NRP2BioGRID, IntAct28514442 details
DEFA1HS6ST1BioGRID, IntAct28514442 details
DEFA1LAMA5BioGRID, IntAct28514442 details
DEFA1PLXNB2BioGRID, IntAct28514442 details
DEFA1MANBABioGRID, IntAct28514442 details
DEFA1MICABioGRID, IntAct28514442 details
DEFA1PLB1IntAct28514442 details
DEFA1FBXO4IntAct28514442 details
DEFA1DEFA1BBioGRID28514442 details