Entity Details

Primary name DYR1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13627
EntryNameDYR1A_HUMAN
FullNameDual specificity tyrosine-phosphorylation-regulated kinase 1A
TaxID9606
Evidenceevidence at protein level
Length763
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDYRK1A

GO terms

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GOName
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0003713 transcription coactivator activity
GO:0003779 actin binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0006468 protein phosphorylation
GO:0007399 nervous system development
GO:0007623 circadian rhythm
GO:0008092 cytoskeletal protein binding
GO:0015631 tubulin binding
GO:0016032 viral process
GO:0016607 nuclear speck
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030424 axon
GO:0030425 dendrite
GO:0031115 negative regulation of microtubule polymerization
GO:0033120 positive regulation of RNA splicing
GO:0034205 amyloid-beta formation
GO:0036289 peptidyl-serine autophosphorylation
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0042802 identical protein binding
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043621 protein self-association
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
GO:0048025 negative regulation of mRNA splicing, via spliceosome
GO:0048156 tau protein binding
GO:0050321 tau-protein kinase activity
GO:0090312 positive regulation of protein deacetylation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR028318 Dual specificity tyrosine-phosphorylation-regulated kinase 1A/BFamilyFamily
IPR044131 Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB07608 N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamideDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
DYR1A_HUMAN1433E_HUMANBioGRID, HPRD, MINT15369779 30773093 details
DYR1A_HUMAN1433B_HUMANBioGRID, HPRD, IntAct17229891 17353931 30773093 details
DYR1A_HUMANDCAF7_HUMANBioGRID, IntAct, MINT14593110 20940704 21777625 23602568 25342745 27173435 27307198 27705803 28514442 30137413 30773093 30979931 31024071 unassigned1312 details
DYR1A_HUMANLZTS2_HUMANBioGRID, IntAct, MINT23602568 26186194 26949739 28514442 29395067 30773093 details
DYR1A_HUMANRB_HUMANBioGRID, IntAct23602568 30137413 details
DYR1A_HUMANCBP_HUMANBioGRID, IntAct23602568 30137413 details
DYR1A_HUMANRN169_HUMANBioGRID, IntAct, MINT23602568 26949739 28325877 30104380 30773093 30979931 31024071 details
DYR1A_HUMANTROAP_HUMANBioGRID, IntAct, MINT23602568 26949739 30773093 31024071 details
DYR1A_HUMANRBL1_HUMANBioGRID, IntAct23602568 details
DYR1A_HUMANKPRP_HUMANBioGRID, IntAct32296183 details
DYR1A_HUMANDYR1A_HUMANBioGRID, DIP, HPRD17229891 23665168 26735018 30137413 30773093 30979931 31024071 details
DYR1A_HUMANSRSF4_HUMANBioGRID14623875 details
DYR1A_HUMANCCNL2_HUMANBioGRID, HPRD14623875 details
DYR1A_HUMANSRSF5_HUMANBioGRID14623875 details
DYR1A_HUMANCLASR_HUMANBioGRID14623875 details
DYR1A_HUMANSRSF1_HUMANBioGRID14623875 details
DYR1A_HUMANDYN1_HUMANBioGRID11877424 19722700 details
DYR1A_HUMANH2B1B_HUMANBioGRID10644696 details
DYR1A_HUMANH31_HUMANBioGRID10644696 details
DYR1A_HUMANH4_HUMANBioGRID10644696 details
DYR1A_HUMANAMPH_HUMANBioGRID16733250 details
DYR1A_HUMANLATS2_HUMANBioGRID21498571 details
DYR1A_HUMANLIN52_HUMANBioGRID21498571 30206359 30773093 details
DYR1A_HUMANSYUA_HUMANBioGRID16959772 details
DYR1A_HUMANA4_HUMANBioGRID21832049 details
DYR1A_HUMANID2_HUMANBioGRID26735018 details
DYR1A_HUMANPRKN_HUMANBioGRID25963095 details
DYR1A_HUMANPEA15_HUMANBioGRID24710276 details
DYR1A_HUMANTAU_HUMANBioGRID11311121 17906291 details
DYR1A_HUMANEI2BE_HUMANBioGRID11311121 details
DYR1A_HUMANPHYIP_HUMANHPRD15694837 details
DYR1A_HUMAN1433G_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 28514442 details
DYR1A_HUMAN1433S_HUMANBioGRID, MINT15778465 details
DYR1A_HUMANHIPK2_HUMANBioGRID, MINT20940704 details
DYR1A_HUMANSIR1_HUMANUniProt20167603 details
DYR1A_HUMANF117B_HUMANBioGRID, IntAct23602568 28514442 30773093 31024071 details
DYR1A_HUMANEP300_HUMANBioGRID, IntAct23602568 30137413 details
DYR1A_HUMANCLH1_HUMANBioGRID19722700 details
DYR1A_HUMANSH3G2_HUMANBioGRID19722700 details
DYR1A_HUMANM3K5_HUMANBioGRID22110360 details
DYR1A_HUMANEGLN2_HUMANBioGRID26735018 details
DYR1A_HUMANARIP4_HUMANBioGRID26412716 30137413 30773093 details
DYR1A_HUMANFBW1A_HUMANBioGRID27807027 details
DYR1A_HUMANXRN1_HUMANBioGRID29395067 30773093 details
DYR1A_HUMANMDM2_HUMANBioGRID30910997 details
DYR1A_HUMANH2AX_HUMANBioGRID30979931 details
DYR1A_HUMANTTP_HUMANBioGRID29395067 details
DYR1A_HUMANCREB1_HUMANHPRD15694837 details
DYR1A_HUMANGLI1_HUMANHPRD12138125 details
DYR1A_HUMANSF3B1_HUMANHPRD16512921 details
DYR1A_HUMANFOXO1_HUMANHPRD11311120 details