Entity Details

Primary name EXOS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13868
EntryNameEXOS2_HUMAN
FullNameExosome complex component RRP4
TaxID9606
Evidenceevidence at protein level
Length293
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesEXOSC2

GO terms

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GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000176 nuclear exosome (RNase complex)
GO:0000177 cytoplasmic exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006364 rRNA processing
GO:0008312 7S RNA binding
GO:0030307 positive regulation of cell growth
GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
GO:0034475 U4 snRNA 3'-end processing
GO:0043488 regulation of mRNA stability
GO:0043928 exonucleolytic catabolism of deadenylated mRNA
GO:0071034 CUT catabolic process
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process
GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process
GO:0071049 nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription
GO:0071051 polyadenylation-dependent snoRNA 3'-end processing

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR004088 K Homology domain, type 1DomainDomain
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR025721 Exosome complex component, N-terminal domainDomainDomain
IPR026699 Exosome complex RNA-binding protein 1/RRP40/RRP4FamilyFamily
IPR036612 K Homology domain, type 1 superfamilyFamilyHomologous superfamily

Diseases

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Interactions

27 interactions

InteractorPartnerSourcesPublicationsLink
EXOS2_HUMANEXOS7_HUMANBioGRID, HPRD, IntAct, UniProt11719186 12419256 15231747 24981860 26186194 26344197 26496610 27173435 28514442 unassigned1312 details
EXOS2_HUMANZN408_HUMANBioGRID, HPRD, IntAct15231747 details
EXOS2_HUMANRNF8_HUMANBioGRID, HPRD, IntAct15231747 details
EXOS2_HUMANEXOS4_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11719186 12419256 17545563 20531386 22939629 24981860 26344197 26496610 27173435 unassigned1312 details
EXOS2_HUMANEXOS9_HUMANBioGRID, HPRD, IntAct, UniProt11719186 12788944 17412707 17545563 22939629 24981860 26344197 26496610 27173435 unassigned1312 details
EXOS2_HUMANMPH6_HUMANBioGRID, UniProt11719186 16396833 24981860 26344197 26496610 28877463 details
EXOS2_HUMANSBK3_HUMANBioGRID, IntAct32296183 details
EXOS2_HUMANGLT13_HUMANBioGRID15231747 details
EXOS2_HUMANSIA7A_HUMANBioGRID15231747 details
EXOS2_HUMANRM48_HUMANBioGRID15231747 details
EXOS2_HUMANPTEN_HUMANBioGRID31685992 details
EXOS2_HUMANRENT1_HUMANBioGRID, HPRD, IntAct14527413 18423202 details
EXOS2_HUMANEXOS3_HUMANBioGRID, IntAct, MINT, UniProt11719186 16396833 17545563 20531389 21255825 22939629 24981860 26186194 26344197 26496610 28514442 32188736 details
EXOS2_HUMANDI3L1_HUMANBioGRID, IntAct, MINT20531386 20531389 24981860 26496610 details
EXOS2_HUMANRRP44_HUMANBioGRID, HPRD, MINT11719186 20531386 26344197 details
EXOS2_HUMANFUBP2_HUMANBioGRID, HPRD, UniProt11719186 15175153 details
EXOS2_HUMANDHYS_HUMANBioGRID, IntAct27173435 unassigned1312 details
EXOS2_HUMANLUM_HUMANBioGRID, IntAct27173435 unassigned1312 details
EXOS2_HUMANLRC47_HUMANBioGRID, IntAct27173435 unassigned1312 details
EXOS2_HUMANSLIT2_HUMANBioGRID, IntAct27173435 unassigned1312 details
EXOS2_HUMANRSRC1_HUMANBioGRID, IntAct27173435 unassigned1312 details
EXOS2_HUMANRENT2_HUMANBioGRID14527413 details
EXOS2_HUMANREN3A_HUMANBioGRID14527413 details
EXOS2_HUMANMET22_HUMANBioGRID23349634 details
EXOS2_HUMANTISB_HUMANBioGRID18326031 details
EXOS2_HUMANOSTM1_HUMANBioGRID32188736 details
EXOS2_HUMANPALS2_HUMANHPRD11719186 details