Entity Details

Primary name DAG1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14118
EntryNameDAG1_HUMAN
FullNameDystroglycan
TaxID9606
Evidenceevidence at protein level
Length895
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDAG1

GO terms

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GOName
GO:0001618 virus receptor activity
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002009 morphogenesis of an epithelium
GO:0002011 morphogenesis of an epithelial sheet
GO:0002162 dystroglycan binding
GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005925 focal adhesion
GO:0006509 membrane protein ectodomain proteolysis
GO:0007411 axon guidance
GO:0007568 aging
GO:0008307 structural constituent of muscle
GO:0009897 external side of plasma membrane
GO:0010470 regulation of gastrulation
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0014894 response to denervation involved in regulation of muscle adaptation
GO:0015631 tubulin binding
GO:0016010 dystrophin-associated glycoprotein complex
GO:0016011 dystroglycan complex
GO:0016021 integral component of membrane
GO:0016203 muscle attachment
GO:0016323 basolateral plasma membrane
GO:0016340 calcium-dependent cell-matrix adhesion
GO:0016476 regulation of embryonic cell shape
GO:0017166 vinculin binding
GO:0019048 modulation by virus of host process
GO:0021675 nerve development
GO:0021682 nerve maturation
GO:0022011 myelination in peripheral nervous system
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0030198 extracellular matrix organization
GO:0030336 negative regulation of cell migration
GO:0031103 axon regeneration
GO:0031643 positive regulation of myelination
GO:0033268 node of Ranvier
GO:0034399 nuclear periphery
GO:0034453 microtubule anchoring
GO:0042169 SH2 domain binding
GO:0042383 sarcolemma
GO:0043034 costamere
GO:0043231 intracellular membrane-bounded organelle
GO:0043236 laminin binding
GO:0043237 laminin-1 binding
GO:0043403 skeletal muscle tissue regeneration
GO:0043409 negative regulation of MAPK cascade
GO:0043434 response to peptide hormone
GO:0044853 plasma membrane raft
GO:0045211 postsynaptic membrane
GO:0045860 positive regulation of protein kinase activity
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0050807 regulation of synapse organization
GO:0051393 alpha-actinin binding
GO:0051898 negative regulation of protein kinase B signaling
GO:0060055 angiogenesis involved in wound healing
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070938 contractile ring
GO:0071260 cellular response to mechanical stimulus
GO:0071397 cellular response to cholesterol
GO:0071679 commissural neuron axon guidance
GO:0071711 basement membrane organization
GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO:0098942 retrograde trans-synaptic signaling by trans-synaptic protein complex
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0099524 postsynaptic cytosol
GO:1904261 positive regulation of basement membrane assembly involved in embryonic body morphogenesis

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR006644 Dystroglycan-type cadherin-likeDomainDomain
IPR008465 Dystroglycan, C-terminalDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015919 Cadherin-like superfamilyFamilyHomologous superfamily
IPR027468 Alpha-dystroglycan domain 2FamilyHomologous superfamily
IPR030398 DG-type SEA domainDomainDomain
IPR041631 Alpha-dystroglycan N-terminal domain 2DomainDomain

Diseases

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Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
DAG1_HUMANUTRN_HUMANBioGRID, HPRD, IntAct, MINT10767429 10769203 30914516 details
DAG1_HUMANDAG1_HUMANHPRD, MINT11423118 11502221 8205617 details
DAG1_HUMANSRC_HUMANBioGRID, HPRD, IntAct11724572 12795607 17474147 details
DAG1_HUMANFYN_HUMANBioGRID, IntAct11724572 17474147 details
DAG1_HUMANGRB2_HUMANBioGRID, HPRD, IntAct10903901 17474147 7744812 details
DAG1_HUMANNCK1_HUMANBioGRID, IntAct11724572 17474147 details
DAG1_HUMANP85A_HUMANIntAct17474147 details
DAG1_HUMANDMD_HUMANBioGRID, HPRD, IntAct10355629 10932245 19109891 7592992 details
DAG1_HUMANAGRIN_HUMANBioGRID, IntAct30914516 8205617 details
DAG1_HUMANLAMA5_HUMANBioGRID, HPRD, IntAct10207021 30914516 details
DAG1_HUMANHMGB1_HUMANUniProt32867128 details
DAG1_HUMANCAV3_HUMANBioGRID, HPRD10988290 details
DAG1_HUMANDRP2_HUMANBioGRID, HPRD11430802 details
DAG1_HUMANCSK_HUMANBioGRID11724572 details
DAG1_HUMANSHC1_HUMANBioGRID, HPRD11724572 details
DAG1_HUMANCAV1_HUMANBioGRID11724572 34079125 details
DAG1_HUMANLAMA2_HUMANBioGRID, HPRD16709410 7925941 details
DAG1_HUMANTBA1A_HUMANBioGRID18341635 details
DAG1_HUMANACTN1_HUMANBioGRID18341635 details
DAG1_HUMANMTAP2_HUMANBioGRID18341635 details
DAG1_HUMANITB1_HUMANBioGRID18341635 details
DAG1_HUMANTLN1_HUMANBioGRID18341635 details
DAG1_HUMANVINC_HUMANBioGRID18341635 details
DAG1_HUMANAGR2_HUMANBioGRID12592373 20888340 details
DAG1_HUMANAGR3_HUMANBioGRID, HPRD12592373 details
DAG1_HUMANRAPSN_HUMANBioGRID, HPRD11342559 7619516 details
DAG1_HUMANPRAX_HUMANBioGRID11430802 details
DAG1_HUMANFAK1_HUMANBioGRID18341635 details
DAG1_HUMANSH3K1_HUMANBioGRID19531213 details
DAG1_HUMANWWP1_HUMANBioGRID, HPRD29635000 9169421 details
DAG1_HUMANAPRIO_HUMANBioGRID11032878 details
DAG1_HUMANPRIO_HUMANBioGRID11032878 details
DAG1_HUMANLAMA1_HUMANHPRD11798066 16709410 7925941 details
DAG1_HUMANWWP2_HUMANHPRD9169421 details
DAG1_HUMANMAGI1_HUMANHPRD9169421 details
DAG1_HUMANPGS1_HUMANHPRD10684260 details