Entity Details

Primary name FGR
Entity type gene
Source Source Link

Details

PrimaryID2268
RefseqGene
SymbolFGR
NameFGR proto-oncogene, Src family tyrosine kinase
Chromosome1
Location1p35.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1989-04-21
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsFGR_HUMAN

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0001819 positive regulation of cytokine production
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0008360 regulation of cell shape
GO:0009615 response to virus
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015629 actin cytoskeleton
GO:0016235 aggresome
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019901 protein kinase binding
GO:0030154 cell differentiation
GO:0030282 bone mineralization
GO:0030335 positive regulation of cell migration
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032587 ruffle membrane
GO:0032815 negative regulation of natural killer cell activation
GO:0034774 secretory granule lumen
GO:0034987 immunoglobulin receptor binding
GO:0034988 Fc-gamma receptor I complex binding
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043306 positive regulation of mast cell degranulation
GO:0043312 neutrophil degranulation
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 innate immune response
GO:0045088 regulation of innate immune response
GO:0045859 regulation of protein kinase activity
GO:0046777 protein autophosphorylation
GO:0048705 skeletal system morphogenesis
GO:0050764 regulation of phagocytosis
GO:0050830 defense response to Gram-positive bacterium
GO:0070062 extracellular exosome

Diseases

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Interactions

83 interactions

InteractorPartnerSourcesPublicationsLink
FGRWASBioGRID, HPRD, MINT10358777 7565724 8805332 8824280 details
FGRSYKBioGRID, HPRD, MINT11672534 15536084 details
FGRERBB2BioGRID, MINT16273093 22973453 details
FGRABI1MINT20598684 details
FGRNR1I2BioGRID, IntAct21988832 details
FGRSTAT3BioGRID, IntAct12244095 21988832 details
FGRALOX5MINT24860872 details
FGRARBioGRID, IntAct24728074 details
FGRKITBioGRID, IntAct24728074 details
FGRMETBioGRID, IntAct24728074 details
FGREGFRBioGRID, IntAct24658140 25402006 31980649 details
FGRDOK1BioGRID, HPRD11071635 22974441 details
FGRHCLS1BioGRID, HPRD10066823 details
FGRDAB2BioGRID, HPRD12473651 details
FGRFASLGBioGRID17164290 details
FGRIKBKGBioGRID20098747 23131831 details
FGRKHDRBS1BioGRID15190072 22745667 details
FGRSMURF1BioGRID20804422 details
FGRSKAP2BioGRID29568343 details
FGRERBB3BioGRID22973453 details
FGRERBB4BioGRID22973453 details
FGRVDRHPRD15919723 details
FGRHSP90AB1BioGRID, IntAct22939624 31980649 details
FGRHSP90AA1BioGRID, IntAct22939624 31980649 details
FGRCCR3BioGRID, HPRD10527858 details
FGRPTK2BioGRID12387730 details
FGRSLAMF1BioGRID, HPRD10229804 details
FGRCBLBioGRID, HPRD12435267 7721825 details
FGRCD24BioGRID, HPRD8753773 details
FGRSH3KBP1BioGRID15707590 details
FGRFLT3BioGRID16684964 details
FGRFGRBioGRID, HPRD31980649 7515063 details
FGRSRCHPRD12387813 12468645 7678701 9208935 details
FGRINPP5DHPRD10229804 details
FGRARRB1HPRD10973280 details
FGRCSKHPRD7515063 8612628 details
FGRYWHAQHPRD10066823 details
FGRSNCAHPRD11162638 11744621 12096713 details
FGRYES1BioGRID, IntAct28514442 31980649 details
FGRCDK14BioGRID, IntAct28514442 details
FGRBAG2BioGRID, IntAct31980649 details
FGRCDK1BioGRID, IntAct31980649 details
FGRHNRNPCBioGRID, IntAct31980649 details
FGRHNRNPCL1BioGRID, IntAct31980649 details
FGRPRPS2BioGRID, IntAct31980649 details
FGRTCP1BioGRID, IntAct31980649 details
FGRHNRNPA2B1BioGRID, IntAct31980649 details
FGRCADBioGRID, IntAct31980649 details
FGRCCT6ABioGRID, IntAct31980649 details
FGRCCT5BioGRID, IntAct31980649 details
FGRCCT3BioGRID, IntAct31980649 details
FGRCCT8BioGRID, IntAct31980649 details
FGRCCT4BioGRID, IntAct31980649 details
FGRHNRNPA3BioGRID, IntAct31980649 details
FGRACTBBioGRID, IntAct31980649 details
FGRPRPS1BioGRID, IntAct31980649 details
FGRRPL23BioGRID, IntAct31980649 details
FGRCCT2BioGRID, IntAct31980649 details
FGRGSTO1BioGRID, IntAct31980649 details
FGRFKBP5BioGRID, IntAct31980649 details
FGRPRPSAP1BioGRID, IntAct31980649 details
FGRCDC37BioGRID, IntAct31980649 details
FGRQPCTBioGRID, IntAct31980649 details
FGRPGAM5BioGRID, IntAct31980649 details
FGRCCT7BioGRID, IntAct31980649 details
FGRSLC25A22BioGRID, IntAct31980649 details
FGRSLC25A18BioGRID, IntAct31980649 details
FGRATAD3ABioGRID, IntAct31980649 details
FGRCORO1CBioGRID, IntAct31980649 details
FGRLYNBioGRID, IntAct31980649 34079125 details
FGRHSPB1BioGRID, IntAct31980649 details
FGRANXA5BioGRID, IntAct31980649 details
FGRFXR1BioGRID, IntAct31980649 details
FGRCOPABioGRID, IntAct31980649 details
FGRTPI1BioGRID, IntAct31980649 details
FGREFTUD2BioGRID, IntAct31980649 details
FGRRANBP10BioGRID, IntAct31980649 details
FGRCDK18BioGRID26186194 28514442 details
FGRCDK9BioGRID26186194 details
FGRHEXIM1BioGRID29845934 details
FGRLARP7BioGRID29845934 details
FGRKIF14BioGRID31586073 details
FGRDDX58BioGRID32513696 details