Entity Details

Primary name MCM6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14566
EntryNameMCM6_HUMAN
FullNameDNA replication licensing factor MCM6
TaxID9606
Evidenceevidence at protein level
Length821
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMCM6

GO terms

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GOName
GO:0000727 double-strand break repair via break-induced replication
GO:0000781 chromosome, telomeric region
GO:0003678 DNA helicase activity
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0016787 hydrolase activity
GO:0036388 pre-replicative complex assembly
GO:0042555 MCM complex
GO:0042802 identical protein binding
GO:0071162 CMG complex
GO:1902969 mitotic DNA replication

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR001208 MCM domainDomainDomain
IPR008049 DNA replication licensing factor Mcm6FamilyFamily
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR018525 Mini-chromosome maintenance, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR027925 MCM N-terminal domainDomainDomain
IPR031327 Mini-chromosome maintenance proteinFamilyFamily
IPR033762 MCM OB domainDomainDomain
IPR041024 Mcm6, C-terminal winged-helix domainDomainDomain
IPR041562 MCM, AAA-lid domainDomainDomain

Diseases

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Interactions

80 interactions

InteractorPartnerSourcesPublicationsLink
MCM6_HUMANORC6_HUMANBioGRID, HPRD, IntAct15232106 details
MCM6_HUMANMCM10_HUMANBioGRID, HPRD, IntAct11095689 15232106 16189514 25416956 26186194 26496610 28514442 details
MCM6_HUMANMCM6_HUMANBioGRID, HPRD, IntAct11095689 12614612 12694531 15232106 16189514 17296731 details
MCM6_HUMANCCNA1_HUMANBioGRID, HPRD, IntAct15232106 details
MCM6_HUMANGEMI_HUMANBioGRID, HPRD, IntAct15232106 details
MCM6_HUMANMCM3_HUMANBioGRID, HPRD, IntAct, UniProt12614612 15232106 17296731 22863883 22939629 26344197 26496610 27621311 28514442 30108253 details
MCM6_HUMANMCM4_HUMANBioGRID, HPRD, IntAct, UniProt12207017 12364596 12614612 12694531 16902406 17296731 22863883 22939629 26344197 26496610 27173435 8798650 unassigned1312 details
MCM6_HUMANI36RA_HUMANBioGRID, HPRD, IntAct16189514 details
MCM6_HUMANC2CD6_HUMANBioGRID, HPRD, IntAct16189514 details
MCM6_HUMANPSA1_HUMANBioGRID, HPRD, IntAct16189514 details
MCM6_HUMANSCNM1_HUMANBioGRID, HPRD, IntAct16189514 details
MCM6_HUMANING5_HUMANBioGRID, HPRD, IntAct16189514 16387653 details
MCM6_HUMANAF9_HUMANBioGRID, HPRD, IntAct16189514 details
MCM6_HUMANMCM2_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt10567526 12207017 12614612 12694531 16189514 16899510 17296731 20211142 22540012 22863883 22939629 25416956 25963833 26167883 26344197 26496610 27173435 30100344 unassigned1312 details
MCM6_HUMANMCM7_HUMANBioGRID, HPRD, IntAct, UniProt12207017 12614612 12694531 16438930 17296731 22939629 23764002 26344197 26496610 27173435 9099751 unassigned1312 details
MCM6_HUMANCDN2A_HUMANBioGRID, IntAct17955473 details
MCM6_HUMANMCMBP_HUMANBioGRID, IntAct, MINT, UniProt17296731 22540012 24190967 24299456 25036637 26344197 26496610 details
MCM6_HUMANCDT1_HUMANBioGRID, HPRD, IntAct, UniProt12192004 18162579 18184650 20202939 21099365 22140117 26496610 details
MCM6_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
MCM6_HUMANRU2B_HUMANBioGRID, IntAct25416956 details
MCM6_HUMANAP4A_HUMANBioGRID, IntAct25416956 details
MCM6_HUMANF161A_HUMANBioGRID, IntAct25416956 details
MCM6_HUMANZBTB9_HUMANBioGRID, IntAct25416956 details
MCM6_HUMANCDC45_HUMANBioGRID, DIP12614612 19805216 details
MCM6_HUMANPSF3_HUMANDIP19805216 details
MCM6_HUMANUBE3A_HUMANBioGRID, IntAct, MINT21653829 29426014 32545848 details
MCM6_HUMANORC1_HUMANBioGRID12614612 details
MCM6_HUMANORC2_HUMANBioGRID, HPRD12614612 details
MCM6_HUMANORC4_HUMANBioGRID12614612 details
MCM6_HUMANRFA1_HUMANBioGRID12614612 details
MCM6_HUMANARF_HUMANBioGRID17955473 details
MCM6_HUMANCDC7_HUMANBioGRID10846177 22540012 details
MCM6_HUMANDBF4A_HUMANBioGRID10846177 22540012 details
MCM6_HUMANESCO2_HUMANBioGRID30100344 details
MCM6_HUMANCHK1_HUMANBioGRID25049228 details
MCM6_HUMANTIF1B_HUMANBioGRID29955894 details
MCM6_HUMANCDC42_HUMANBioGRID31478661 details
MCM6_HUMANSMC1A_HUMANBioGRID, HPRD, IntAct16438930 27173435 unassigned1312 details
MCM6_HUMANSSRP1_HUMANBioGRID, IntAct, MINT16902406 21055985 28514442 details
MCM6_HUMANCRCM_HUMANIntAct17353931 details
MCM6_HUMANHLAB_HUMANIntAct17353931 details
MCM6_HUMANTRAF6_HUMANIntAct17353931 details
MCM6_HUMANTONSL_HUMANBioGRID, MINT21055984 21055985 21113133 details
MCM6_HUMANMCM5_HUMANBioGRID, UniProt11248027 17296731 22939629 25963833 26344197 details
MCM6_HUMANCDC6_HUMANIntAct23397142 details
MCM6_HUMANPLK1_HUMANBioGRID, IntAct15654075 27173435 31730000 unassigned1312 details
MCM6_HUMANSBNO1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM6_HUMANHSF1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM6_HUMANSOX4_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM6_HUMANANK3_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM6_HUMANJIP4_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM6_HUMANBCR_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM6_HUMANATG2B_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM6_HUMANCD11A_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM6_HUMANTF3C4_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM6_HUMANEP15R_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM6_HUMANPP4R2_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM6_HUMANGAPD1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM6_HUMANSF3A1_HUMANBioGRID, IntAct22939629 27173435 unassigned1312 details
MCM6_HUMANRELCH_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM6_HUMANSMC3_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM6_HUMANUBP15_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM6_HUMANNS1BP_HUMANBioGRID, IntAct27173435 unassigned1312 details
MCM6_HUMANASF1B_HUMANBioGRID, IntAct20227376 21055984 26527279 28514442 details
MCM6_HUMANASF1A_HUMANBioGRID, IntAct22407294 28514442 details
MCM6_HUMANMCM8_HUMANBioGRID, HPRD12771218 details
MCM6_HUMANPMS1_HUMANBioGRID17148452 details
MCM6_HUMANAIRE_HUMANBioGRID20085707 details
MCM6_HUMANSRRM2_HUMANBioGRID16159877 details
MCM6_HUMANEMD_HUMANBioGRID17620012 details
MCM6_HUMANHDAC5_HUMANBioGRID21081666 details
MCM6_HUMANMMS22_HUMANBioGRID21055984 21055985 details
MCM6_HUMANCCND1_HUMANBioGRID12519773 details
MCM6_HUMANFACD2_HUMANBioGRID23993743 details
MCM6_HUMANSPRTN_HUMANBioGRID27871366 details
MCM6_HUMANRECQ4_HUMANBioGRID19696745 29229926 details
MCM6_HUMANESCO1_HUMANBioGRID30100344 details
MCM6_HUMANRFA2_HUMANBioGRID20679368 details
MCM6_HUMANSUV91_HUMANBioGRID29955894 details
MCM6_HUMANCRLS1_HUMANHPRD12771218 details