Entity Details

Primary name GBA
Entity type gene
Source Source Link

Details

PrimaryID2629
RefseqGeneNG_009783
SymbolGBA
Nameglucosylceramidase beta
Chromosome1
Location1q22
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-17
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsGLCM_HUMAN

GO terms

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GOName
GO:0004348 glucosylceramidase activity
GO:0005102 signaling receptor binding
GO:0005124 scavenger receptor binding
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0006680 glucosylceramide catabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0006914 autophagy
GO:0007040 lysosome organization
GO:0008203 cholesterol metabolic process
GO:0008340 determination of adult lifespan
GO:0009267 cellular response to starvation
GO:0009268 response to pH
GO:0014004 microglia differentiation
GO:0016241 regulation of macroautophagy
GO:0019882 antigen processing and presentation
GO:0019898 extrinsic component of membrane
GO:0019915 lipid storage
GO:0021694 cerebellar Purkinje cell layer formation
GO:0021859 pyramidal neuron differentiation
GO:0023021 termination of signal transduction
GO:0030259 lipid glycosylation
GO:0031333 negative regulation of protein-containing complex assembly
GO:0032006 regulation of TOR signaling
GO:0032268 regulation of cellular protein metabolic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032715 negative regulation of interleukin-6 production
GO:0033077 T cell differentiation in thymus
GO:0033561 regulation of water loss via skin
GO:0033574 response to testosterone
GO:0035307 positive regulation of protein dephosphorylation
GO:0043202 lysosomal lumen
GO:0043243 positive regulation of protein-containing complex disassembly
GO:0043407 negative regulation of MAP kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043589 skin morphogenesis
GO:0043627 response to estrogen
GO:0046512 sphingosine biosynthetic process
GO:0046513 ceramide biosynthetic process
GO:0046527 glucosyltransferase activity
GO:0048469 cell maturation
GO:0048854 brain morphogenesis
GO:0048872 homeostasis of number of cells
GO:0050295 steryl-beta-glucosidase activity
GO:0050728 negative regulation of inflammatory response
GO:0050905 neuromuscular process
GO:0051247 positive regulation of protein metabolic process
GO:0051402 neuron apoptotic process
GO:0061518 microglial cell proliferation
GO:0061744 motor behavior
GO:0070062 extracellular exosome
GO:0071356 cellular response to tumor necrosis factor
GO:0071425 hematopoietic stem cell proliferation
GO:0071548 response to dexamethasone
GO:0072676 lymphocyte migration
GO:0097066 response to thyroid hormone
GO:1901215 negative regulation of neuron death
GO:1901805 beta-glucoside catabolic process
GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process
GO:1903061 positive regulation of protein lipidation
GO:1904457 positive regulation of neuronal action potential
GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
GO:1905037 autophagosome organization
GO:1905165 regulation of lysosomal protein catabolic process

Diseases

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Interactions

56 interactions

InteractorPartnerSourcesPublicationsLink
GBANEDD4BioGRID19953087 details
GBASNCABioGRID21653695 23266198 details
GBAOGTBioGRID32994395 details
GBALAMP1MINT20148966 details
GBARAB21BioGRID, IntAct27173435 unassigned1312 details
GBARAB14BioGRID, IntAct27173435 unassigned1312 details
GBACOMTBioGRID, IntAct27173435 unassigned1312 details
GBAHCCSBioGRID, IntAct27173435 unassigned1312 details
GBARDH11BioGRID, IntAct27173435 unassigned1312 details
GBAESYT1BioGRID, IntAct27173435 unassigned1312 details
GBAPOMKBioGRID, IntAct27173435 unassigned1312 details
GBAARL8BBioGRID, IntAct27173435 unassigned1312 details
GBATCP1BioGRID, DIP21098288 22160715 details
GBACBLBioGRID, DIP21098288 details
GBAHSP90AA1BioGRID22160715 details
GBAHSPA4BioGRID22160715 details
GBAPRKNBioGRID20643691 details
GBAATP6V1B1BioGRID21674799 details
GBAITCHBioGRID23255161 details
GBANUDCD1BioGRID25036637 details
GBAPSAPHPRD7613473 details
GBAA2MMINT17174955 details
GBAATP6V1AIntAct21674799 details
GBARPS6KA3BioGRID, IntAct26496610 details
GBAZFP91BioGRID, IntAct26496610 details
GBACANXBioGRID, IntAct26496610 details
GBAZCCHC8BioGRID, IntAct26496610 details
GBAHSP90B1BioGRID, IntAct26496610 details
GBAIMP3BioGRID, IntAct26496610 details
GBAZMYND11BioGRID, IntAct26496610 details
GBAMTREXBioGRID, IntAct26496610 details
GBAJPH1BioGRID, IntAct26496610 details
GBAATP5PFBioGRID, IntAct26496610 details
GBASCAMP3BioGRID, IntAct26496610 details
GBAHYOU1BioGRID, IntAct26496610 details
GBAHSPD1BioGRID, IntAct26496610 details
GBARNF20BioGRID, IntAct26496610 details
GBABMP2KBioGRID, IntAct26496610 details
GBACCT8BioGRID, IntAct26496610 details
GBACCT3BioGRID, IntAct26496610 details
GBATOP3BBioGRID, IntAct26496610 details
GBADHCR24BioGRID, IntAct26496610 details
GBAFGD6BioGRID, IntAct26496610 details
GBAFMR1BioGRID, IntAct26496610 details
GBAB4GALT7BioGRID, IntAct26496610 details
GBARAB27BBioGRID, IntAct28514442 details
GBASCARB2BioGRID, IntAct30833792 details
GBAPI4KBIntAct23572552 details
GBAFBXO6BioGRID22268729 details
GBAPCBP2BioGRID26344197 details
GBANTRK1BioGRID25921289 details
GBANHLRC2BioGRID31594818 details
GBAAGKBioGRID28712724 details
GBAEYA1BioGRID28675297 details
GBARIN3BioGRID32552912 details
GBASEC61BBioGRID34079125 details