Entity Details

Primary name GCH1
Entity type gene
Source Source Link

Details

PrimaryID2643
RefseqGeneNG_008647
SymbolGCH1
NameGTP cyclohydrolase 1
Chromosome14
Location14q22.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-17
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsGCH1_HUMAN

GO terms

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GOName
GO:0003924 GTPase activity
GO:0003934 GTP cyclohydrolase I activity
GO:0005509 calcium ion binding
GO:0005525 GTP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006729 tetrahydrobiopterin biosynthetic process
GO:0006809 nitric oxide biosynthetic process
GO:0008217 regulation of blood pressure
GO:0008270 zinc ion binding
GO:0010460 positive regulation of heart rate
GO:0014916 regulation of lung blood pressure
GO:0030742 GTP-dependent protein binding
GO:0031369 translation initiation factor binding
GO:0031410 cytoplasmic vesicle
GO:0031965 nuclear membrane
GO:0032496 response to lipopolysaccharide
GO:0032991 protein-containing complex
GO:0034341 response to interferon-gamma
GO:0034612 response to tumor necrosis factor
GO:0035998 7,8-dihydroneopterin 3'-triphosphate biosynthetic process
GO:0042311 vasodilation
GO:0042416 dopamine biosynthetic process
GO:0042559 pteridine-containing compound biosynthetic process
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044306 neuron projection terminus
GO:0044877 protein-containing complex binding
GO:0045776 negative regulation of blood pressure
GO:0046146 tetrahydrobiopterin metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0048265 response to pain
GO:0050884 neuromuscular process controlling posture
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051019 mitogen-activated protein kinase binding
GO:0065003 protein-containing complex assembly
GO:2000121 regulation of removal of superoxide radicals

Diseases

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Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
GCH1AHSA1BioGRID, HPRD, IntAct16696853 details
GCH1HSPA8BioGRID, HPRD, IntAct16696853 details
GCH1RAB26BioGRID, HPRD, IntAct16696853 details
GCH1CNRIP1BioGRID, IntAct16696853 details
GCH1RLFBioGRID, HPRD, IntAct16696853 details
GCH1SP3BioGRID, IntAct16696853 details
GCH1GCH1BioGRID, HPRD, IntAct11087827 16696853 2463916 details
GCH1GCHFRBioGRID, HPRD, IntAct16696853 8702680 details
GCH1GIT2BioGRID, IntAct21988832 details
GCH1YWHAZBioGRID, IntAct21988832 details
GCH1CDC37BioGRID, MINT21900206 details
GCH1SH3GL2BioGRID, MINT21900206 details
GCH1TNPO2BioGRID, IntAct32296183 details
GCH1TNPO3BioGRID, IntAct32296183 details
GCH1ATP1B1BioGRID, HPRD16696853 details
GCH1RPH3ABioGRID, HPRD7802677 details
GCH1PACSIN3BioGRID19294699 details
GCH1CALML5BioGRID19294699 details
GCH1CALML6BioGRID19294699 details
GCH1RGS19BioGRID19294699 details
GCH1PPM1BBioGRID19294699 details
GCH1MAP2K4BioGRID19294699 details
GCH1MAP2K5BioGRID19294699 details
GCH1MAPK12BioGRID19294699 details
GCH1MAPK10BioGRID19294699 details
GCH1CAMKK1BioGRID19294699 details
GCH1CSNK1G1BioGRID19294699 details
GCH1CSNK2A1BioGRID19294699 details
GCH1CSNK2BBioGRID19294699 details
GCH1PRKAR2ABioGRID19294699 details
GCH1PRKAR2BBioGRID19294699 details
GCH1OSBPL9BioGRID, IntAct19615732 details
GCH1RPS12BioGRID, IntAct30021884 details
GCH1SNX9BioGRID, IntAct30833792 details
GCH1GID8BioGRID, IntAct30833792 details
GCH1MID1IP1BioGRID, IntAct30833792 details
GCH1RMND5ABioGRID, IntAct30833792 details
GCH1WDR26BioGRID, IntAct30833792 details
GCH1RANBP9BioGRID, IntAct30833792 details
GCH1USP7BioGRID, IntAct30833792 details
GCH1USP9XIntAct30833792 details
GCH1ARMC8BioGRID, IntAct30833792 details
GCH1MAEABioGRID, IntAct30833792 details
GCH1RANBP10BioGRID, IntAct30833792 details
GCH1ELOBBioGRID, IntAct30833792 details
GCH1SQSTM1BioGRID, IntAct30833792 details
GCH1EIF4G1BioGRID, IntAct30833792 details
GCH1RRM1BioGRID, IntAct30833792 details
GCH1PLOD2BioGRID, IntAct30833792 details
GCH1GID4BioGRID30833792 details
GCH1SECTM1BioGRID30833792 details