Entity Details

Primary name HCLS1
Entity type gene
Source Source Link

Details

PrimaryID3059
RefseqGene
SymbolHCLS1
Namehematopoietic cell-specific Lyn substrate 1
Chromosome3
Location3q13.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-17
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsHCLS1_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006355 regulation of transcription, DNA-templated
GO:0008284 positive regulation of cell population proliferation
GO:0009725 response to hormone
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0030041 actin filament polymerization
GO:0030218 erythrocyte differentiation
GO:0030427 site of polarized growth
GO:0030833 regulation of actin filament polymerization
GO:0030854 positive regulation of granulocyte differentiation
GO:0030864 cortical actin cytoskeleton
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0042307 positive regulation of protein import into nucleus
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0045651 positive regulation of macrophage differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051015 actin filament binding
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0071345 cellular response to cytokine stimulus
GO:2000107 negative regulation of leukocyte apoptotic process
GO:2000251 positive regulation of actin cytoskeleton reorganization

Diseases

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Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
HCLS1SH2D4ABioGRID, HPRD, IntAct16189514 25416956 31515488 32296183 details
HCLS1QKIBioGRID, HPRD, IntAct16713569 details
HCLS1WIPF1mbinfo21398607 details
HCLS1CASP3BioGRID, HPRD, IntAct11689006 11988074 25241761 details
HCLS1TERF1bhf-ucl, BioGRID21044950 details
HCLS1SH3BP2BioGRID, IntAct32296183 details
HCLS1ADAM10UniProt25036101 details
HCLS1SSBP3BioGRID, IntAct20211142 details
HCLS1TRIM29BioGRID, IntAct20211142 details
HCLS1ZBTB25BioGRID, IntAct20211142 details
HCLS1LZTR1BioGRID, IntAct20211142 details
HCLS1BLZF1BioGRID, IntAct20211142 details
HCLS1IKBKGBioGRID, IntAct20211142 details
HCLS1CSNK2A1BioGRID, HPRD10806407 11988074 details
HCLS1ACTR3BioGRID12534372 details
HCLS1FGRBioGRID, HPRD10066823 details
HCLS1GRB2BioGRID9670936 details
HCLS1HAX1HPRD9058808 details
HCLS1LYNBioGRID, HPRD, MINT10066823 15795233 7682714 9104825 details
HCLS1WASHPRD, mbinfo15166239 21398607 details
HCLS1SYKBioGRID, HPRD, IntAct25241761 9104825 details
HCLS1MAP4K1BioGRID, HPRD10233887 details
HCLS1CD79ABioGRID, HPRD7927516 details
HCLS1KCNA3BioGRID25739456 details
HCLS1U2AF2BioGRID26641092 details
HCLS1HS1BP3HPRD10590261 details
HCLS1ACTR2HPRD12534372 details
HCLS1ACTA1HPRD12534372 details
HCLS1CFTRIntAct17110338 details
HCLS1NOTCH1BioGRID, MINT23022380 details
HCLS1SNCABioGRID, IntAct28514442 details
HCLS1SNX5BioGRID, IntAct28514442 details
HCLS1SNX1BioGRID, IntAct28514442 details
HCLS1ENGBioGRID, UniProt31540324 details
HCLS1ATG16L1BioGRID30196744 details
HCLS1DCAF15BioGRID31452512 details
HCLS1CLUAP1BioGRID29615496 details
HCLS1NHLRC2BioGRID30397336 details
HCLS1DDX58BioGRID32513696 details