Entity Details

Primary name HLA-B
Entity type gene
Source Source Link

Details

PrimaryID3106
RefseqGeneNG_023187
SymbolHLA-B
Namemajor histocompatibility complex, class I, B
Chromosome6
Location6p21.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1991-10-04
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsHLAB_HUMAN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002250 adaptive immune response
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
GO:0002667 regulation of T cell anergy
GO:0005102 signaling receptor binding
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006952 defense response
GO:0006955 immune response
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0016032 viral process
GO:0016045 detection of bacterium
GO:0030667 secretory granule membrane
GO:0030670 phagocytic vesicle membrane
GO:0031901 early endosome membrane
GO:0032655 regulation of interleukin-12 production
GO:0032675 regulation of interleukin-6 production
GO:0042270 protection from natural killer cell mediated cytotoxicity
GO:0042605 peptide antigen binding
GO:0042612 MHC class I protein complex
GO:0043312 neutrophil degranulation
GO:0046977 TAP binding
GO:0050776 regulation of immune response
GO:0051087 chaperone binding
GO:0055038 recycling endosome membrane
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0070062 extracellular exosome
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:2001198 regulation of dendritic cell differentiation

Diseases

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Disease IDSourceNameDescription
106300 OMIMSpondyloarthropathy 1 (SPDA1)A chronic rheumatic disease with multifactorial inheritance. It includes a spectrum of related disorders comprising ankylosing spondylitis, a subset of psoriatic arthritis, reactive arthritis (e.g. Reiter syndrome), arthritis associated with inflammatory bowel disease and undifferentiated spondyloarthropathy. These disorders may occur simultaneously or sequentially in the same patient, probably representing various phenotypic expressions of the same disease. Ankylosing spondylitis is the form of rheumatoid arthritis affecting the spine and is considered the prototype of seronegative spondyloarthropathies. It produces pain and stiffness as a result of inflammation of the sacroiliac, intervertebral, and costovertebral joints. Disease susceptibility is associated with variants affecting the gene represented in this entry. A restricted number of HLA-B*27 subtypes can be associated with ankylosing spondylitis and other B*27-related diseases, and an elevated frequency of the B*27:02 allele in ankylosing spondylitis patients is identified. The allele B*27:07 seems to have a protective role in some populations because it was found only in the healthy controls.
608579 OMIMStevens-Johnson syndrome (SJS)A rare blistering mucocutaneous disease that share clinical and histopathologic features with toxic epidermal necrolysis. Both disorders are characterized by high fever, malaise, and a rapidly developing blistering exanthema of macules and target-like lesions accompanied by mucosal involvement. Stevens-Johnson syndrome is a milder disease characterized by destruction and detachment of the skin epithelium and mucous membranes involving less than 10% of the body surface area. Ocular symptoms include ulcerative conjunctivitis, keratitis, iritis, uveitis and sometimes blindness. It can be caused by a severe adverse reaction to particular types of medication, although Mycoplasma infections may induce some cases. Disease susceptibility is associated with variants affecting the gene represented in this entry. Increased susceptibility to Stevens-Johnson syndrome is conferred by allele B*15:02.

Interactions

354 interactions

InteractorPartnerSourcesPublicationsLink
HLA-BB2MBioGRID, HPRD, IntAct, MINT10975842 11738047 11823531 12244049 17057332 2450918 26186194 27649529 28514442 8624811 8624812 details
HLA-BATF7IPHPRD, MINT15231748 details
HLA-BARHGEF4BioGRID, IntAct20936779 details
HLA-BSTAT1BioGRID, IntAct21988832 details
HLA-BKIR2DS4IntAct19858347 details
HLA-BKIR2DL3IntAct19858347 details
HLA-BKIR3DL2IntAct24018270 details
HLA-BKIR2DL1IntAct28546555 details
HLA-BNLRP12I2D32226298 details
HLA-BLILRB1BioGRID, HPRD12853576 details
HLA-BCD8ABioGRID, HPRD10809759 9331948 details
HLA-BTRIB3BioGRID18276110 details
HLA-BHLA-CBioGRID, IntAct17353931 26186194 28514442 details
HLA-BPEBP1IntAct17353931 details
HLA-BEIF3IIntAct17353931 details
HLA-BRANGAP1IntAct17353931 details
HLA-BHSPE1IntAct17353931 details
HLA-BPGDIntAct17353931 details
HLA-BCACYBPIntAct17353931 details
HLA-BDYNLRB1IntAct17353931 details
HLA-BTXNIntAct17353931 details
HLA-BUQCRC2IntAct17353931 details
HLA-BCLPPIntAct17353931 details
HLA-BSTRAPIntAct17353931 details
HLA-BMTPNIntAct17353931 details
HLA-BTPP2IntAct17353931 details
HLA-BPPIBIntAct17353931 details
HLA-BARF6IntAct17353931 details
HLA-BDCTPP1IntAct17353931 details
HLA-BOATIntAct17353931 details
HLA-BACTR1AIntAct17353931 details
HLA-BMCM3IntAct17353931 details
HLA-BHLA-ABioGRID, IntAct17353931 26186194 28514442 details
HLA-BPSMB3IntAct17353931 details
HLA-BGANABIntAct17353931 details
HLA-BATP6V1AIntAct17353931 details
HLA-BZNRD2IntAct17353931 details
HLA-BCDKN2AIntAct17353931 details
HLA-BCYB5BIntAct17353931 details
HLA-BRPS14IntAct17353931 details
HLA-BGOT2IntAct17353931 details
HLA-BRAB5CIntAct17353931 details
HLA-BACAT2IntAct17353931 details
HLA-BSERBP1IntAct17353931 details
HLA-BVPS35IntAct17353931 details
HLA-BMCM6IntAct17353931 details
HLA-BSEC63IntAct17353931 details
HLA-BPPP2CBIntAct17353931 details
HLA-BTAGLN2IntAct17353931 details
HLA-BSDHABioGRID, IntAct17353931 29128334 details
HLA-BMIFIntAct17353931 details
HLA-BGLRX5IntAct17353931 details
HLA-BIGF2BP1IntAct17353931 details
HLA-BSLC1A5IntAct17353931 details
HLA-BKCTD12IntAct17353931 details
HLA-BRUVBL2IntAct17353931 details
HLA-BNAA15IntAct17353931 details
HLA-BRPL32IntAct17353931 details
HLA-BCD81IntAct17353931 details
HLA-BCAPZA1IntAct17353931 details
HLA-BLRPPRCIntAct17353931 details
HLA-BTARDBPIntAct17353931 details
HLA-BFSCN1IntAct17353931 details
HLA-BFKBP3IntAct17353931 details
HLA-BWDR48IntAct17353931 details
HLA-BPSMB6IntAct17353931 details
HLA-BAIMP1IntAct17353931 details
HLA-BSNRPB2IntAct17353931 details
HLA-BAHSA1IntAct17353931 details
HLA-BVAPAIntAct17353931 details
HLA-BDAD1IntAct17353931 details
HLA-BEIF3DIntAct17353931 details
HLA-BPGRMC1IntAct17353931 details
HLA-BC11orf58IntAct17353931 details
HLA-BCAPRIN1IntAct17353931 details
HLA-BRAB21IntAct17353931 details
HLA-BSMC2IntAct17353931 details
HLA-BPDIA4IntAct17353931 details
HLA-BHBA1IntAct17353931 details
HLA-BHBA2IntAct17353931 details
HLA-BSEPTIN2IntAct17353931 details
HLA-BRPL38IntAct17353931 details
HLA-BAPEX1IntAct17353931 details
HLA-BEIF3FIntAct17353931 details
HLA-BUBE2KIntAct17353931 details
HLA-BAIFM1IntAct17353931 details
HLA-BARL1IntAct17353931 details
HLA-BNASPIntAct17353931 details
HLA-BFHL1IntAct17353931 details
HLA-BEEF1B2IntAct17353931 details
HLA-BPSMB4IntAct17353931 details
HLA-BDHX9IntAct17353931 details
HLA-BSTMN1IntAct17353931 details
HLA-BLAGE3IntAct17353931 details
HLA-BRPL3IntAct17353931 details
HLA-BPSMD6IntAct17353931 details
HLA-BSFXN1IntAct17353931 details
HLA-BCSDE1IntAct17353931 details
HLA-BPSME3IntAct17353931 details
HLA-BRBBP4IntAct17353931 details
HLA-BDRG1IntAct17353931 details
HLA-BACAT1IntAct17353931 details
HLA-BEEF1DIntAct17353931 details
HLA-BPSMA1IntAct17353931 details
HLA-BNUDCIntAct17353931 details
HLA-BRPL29IntAct17353931 details
HLA-BPSMA6IntAct17353931 details
HLA-BSRP68IntAct17353931 details
HLA-BPSMD13IntAct17353931 details
HLA-BSHMT2IntAct17353931 details
HLA-BTOMM40IntAct17353931 details
HLA-BGDI1IntAct17353931 details
HLA-BRAB2AIntAct17353931 details
HLA-BGRPEL1IntAct17353931 details
HLA-BTKTIntAct17353931 details
HLA-BPA2G4IntAct17353931 details
HLA-BPSMD3IntAct17353931 details
HLA-BPFKPIntAct17353931 details
HLA-BSNX3IntAct17353931 details
HLA-BNUDT5IntAct17353931 details
HLA-BS100A11IntAct17353931 details
HLA-BMTHFD1IntAct17353931 details
HLA-BTRMT112IntAct17353931 details
HLA-BSLIRPIntAct17353931 details
HLA-BMAP2K1IntAct17353931 details
HLA-BSND1IntAct17353931 details
HLA-BANXA2IntAct17353931 details
HLA-BTUFMIntAct17353931 details
HLA-BHPRT1IntAct17353931 details
HLA-BPSMB1IntAct17353931 details
HLA-BRAB7AIntAct17353931 details
HLA-BEIF2S3IntAct17353931 details
HLA-BRARS1IntAct17353931 details
HLA-BAASDHPPTIntAct17353931 details
HLA-BPSMA7IntAct17353931 details
HLA-BGOT1IntAct17353931 details
HLA-BCSIntAct17353931 details
HLA-BDDX21IntAct17353931 details
HLA-BSBDSIntAct17353931 details
HLA-BLMNB1IntAct17353931 details
HLA-BPSMC1IntAct17353931 details
HLA-BDIABLOIntAct17353931 details
HLA-BDYNLL1IntAct17353931 details
HLA-BPDCD5IntAct17353931 details
HLA-BSRP14IntAct17353931 details
HLA-BMRPL40IntAct17353931 details
HLA-BUBA2IntAct17353931 details
HLA-BCOPS3IntAct17353931 details
HLA-BTXNDC17IntAct17353931 details
HLA-BPSMD4IntAct17353931 details
HLA-BSOD2IntAct17353931 details
HLA-BCALM1IntAct17353931 details
HLA-BCALM2IntAct17353931 details
HLA-BCALM3IntAct17353931 details
HLA-BRPN1IntAct17353931 details
HLA-BALDH9A1IntAct17353931 details
HLA-BCOX2IntAct17353931 details
HLA-BSEC23AIntAct17353931 details
HLA-BCLIC1IntAct17353931 details
HLA-BCSTBIntAct17353931 details
HLA-BHSPA4LIntAct17353931 details
HLA-BTSNIntAct17353931 details
HLA-BSETIntAct17353931 details
HLA-BDDTIntAct17353931 details
HLA-BSYNCRIPIntAct17353931 details
HLA-BUBE2D3IntAct17353931 details
HLA-BUSP14IntAct17353931 details
HLA-BRANBP1IntAct17353931 details
HLA-BTTLL12IntAct17353931 details
HLA-BECHS1IntAct17353931 details
HLA-BHINT1IntAct17353931 details
HLA-BTIMM13IntAct17353931 details
HLA-BKPNA3IntAct17353931 details
HLA-BVMA21IntAct17353931 details
HLA-BRAB1BIntAct17353931 details
HLA-BBTF3IntAct17353931 details
HLA-BRCC2IntAct17353931 details
HLA-BRPL37AIntAct17353931 details
HLA-BATP5MGIntAct17353931 details
HLA-BNDUFS1IntAct17353931 details
HLA-BDDOSTIntAct17353931 details
HLA-BLTA4HIntAct17353931 details
HLA-BMCM7IntAct17353931 details
HLA-BLRRC40IntAct17353931 details
HLA-BPCBP1IntAct17353931 details
HLA-BMCTS1IntAct17353931 details
HLA-BSGTAIntAct17353931 details
HLA-BPABPC1IntAct17353931 details
HLA-BPCMT1IntAct17353931 details
HLA-BHADHAIntAct17353931 details
HLA-BBANF1IntAct17353931 details
HLA-BSSR1IntAct17353931 details
HLA-BRHOAIntAct17353931 details
HLA-BNAP1L1IntAct17353931 details
HLA-BPNPIntAct17353931 details
HLA-BGFPT1IntAct17353931 details
HLA-BTFRCIntAct17353931 details
HLA-BLRRC59IntAct17353931 details
HLA-BHNRNPMIntAct17353931 details
HLA-BNUP43IntAct17353931 details
HLA-BIARS2IntAct17353931 details
HLA-BTPM3IntAct17353931 details
HLA-BTBCEIntAct17353931 details
HLA-BSMC3IntAct17353931 details
HLA-BSNRPA1IntAct17353931 details
HLA-BRAB14IntAct17353931 details
HLA-BGMPSIntAct17353931 details
HLA-BERP29IntAct17353931 details
HLA-BRAB6AIntAct17353931 details
HLA-BSLC25A1IntAct17353931 details
HLA-BMARS1IntAct17353931 details
HLA-BDNAJA1IntAct17353931 details
HLA-BADSS2IntAct17353931 details
HLA-BRPL24IntAct17353931 details
HLA-BEIF3HIntAct17353931 details
HLA-BRRM1IntAct17353931 details
HLA-BPFN2IntAct17353931 details
HLA-BRPS9IntAct17353931 details
HLA-BSRP72IntAct17353931 details
HLA-BPREPIntAct17353931 details
HLA-BAKR1B1IntAct17353931 details
HLA-BDUSP3IntAct17353931 details
HLA-BTRIP11IntAct17353931 details
HLA-BPFKLIntAct17353931 details
HLA-BAKR7A2IntAct17353931 details
HLA-BCOPG1IntAct17353931 details
HLA-BMAPK1IntAct17353931 details
HLA-BGLULIntAct17353931 details
HLA-BVDAC3IntAct17353931 details
HLA-BNPM1IntAct17353931 details
HLA-BNUTF2IntAct17353931 details
HLA-BCKMT1BIntAct17353931 details
HLA-BCKMT1AIntAct17353931 details
HLA-BRTCAIntAct17353931 details
HLA-BPDCD6IPIntAct17353931 details
HLA-BPSMD2IntAct17353931 details
HLA-BBCAP31IntAct17353931 details
HLA-BCTPS1IntAct17353931 details
HLA-BSUPT16HIntAct17353931 details
HLA-BSEC11AIntAct17353931 details
HLA-BPCNAIntAct17353931 details
HLA-BESDIntAct17353931 details
HLA-BMAPRE1IntAct17353931 details
HLA-BAFPIntAct17353931 details
HLA-BRPA3IntAct17353931 details
HLA-BCRKIntAct17353931 details
HLA-BCPSF6IntAct17353931 details
HLA-BSEC13IntAct17353931 details
HLA-BNPEPPSIntAct17353931 details
HLA-BRPL23AIntAct17353931 details
HLA-BFUSIntAct17353931 details
HLA-BCYCSIntAct17353931 details
HLA-BGSPT1IntAct17353931 details
HLA-BACTR2IntAct17353931 details
HLA-BARPC2IntAct17353931 details
HLA-BGARS1IntAct17353931 details
HLA-BPSMC6IntAct17353931 details
HLA-BPTGES3IntAct17353931 details
HLA-BTRAP1IntAct17353931 details
HLA-BNUP155IntAct17353931 details
HLA-BEXOSC4IntAct17353931 details
HLA-BTPT1IntAct17353931 details
HLA-BCBR1IntAct17353931 details
HLA-BMYL6IntAct17353931 details
HLA-BAPEHIntAct17353931 details
HLA-BTAPBPLIntAct26439010 details
HLA-BKIR3DS1IntAct27649529 details
HLA-BKIR3DL1HPRD, IntAct12134147 27649529 8046332 details
HLA-BH2AC8IntAct30021884 details
HLA-BH2AC4IntAct30021884 details
HLA-BHSPA5BioGRID24155957 details
HLA-BHLA-BBioGRID, HPRD12853576 25132672 9531263 details
HLA-BEDEM1BioGRID25132672 details
HLA-BCXCR4BioGRID18083706 details
HLA-BCALRBioGRID11823531 details
HLA-BTAP1BioGRID11823531 details
HLA-BPDIA3BioGRID11823531 details
HLA-BCSF1HPRD15494511 details
HLA-BSRCHPRD6304688 details
HLA-BMAGEA1HPRD10363990 details
HLA-BKLRD1HPRD8046333 details
HLA-BPLS3BioGRID, IntAct17353931 details
HLA-BMSNBioGRID, IntAct17353931 details
HLA-BPFASBioGRID, IntAct17353931 details
HLA-BPSMD1BioGRID, IntAct17353931 details
HLA-BTARS1BioGRID, IntAct17353931 details
HLA-BVARS1BioGRID, IntAct17353931 details
HLA-BEZRBioGRID, IntAct17353931 details
HLA-BRUVBL1BioGRID, IntAct17353931 details
HLA-BPAICSBioGRID, IntAct17353931 details
HLA-BVCPBioGRID, IntAct17353931 details
HLA-BAHCYBioGRID, IntAct17353931 details
HLA-BTRIM28BioGRID, IntAct17353931 details
HLA-BGABARAPIntAct20562859 details
HLA-BERBB3BioGRID, IntAct24189400 details
HLA-BSLC38A1IntAct25561175 details
HLA-BPI4KABioGRID, IntAct26186194 28514442 details
HLA-BTMPRSS11BBioGRID, IntAct28514442 details
HLA-BASIC4BioGRID, IntAct28514442 details
HLA-BTMEM30ABioGRID, IntAct28514442 details
HLA-BSGSM3BioGRID, IntAct26186194 28514442 details
HLA-BINTS5BioGRID, IntAct26186194 28514442 details
HLA-BARFGEF1BioGRID, IntAct26186194 28514442 details
HLA-BARFGEF2BioGRID, IntAct26186194 28514442 details
HLA-BERAP1BioGRID, IntAct26186194 28514442 details
HLA-BC1orf112BioGRID, IntAct26186194 28514442 details
HLA-BINTS4BioGRID, IntAct26186194 28514442 details
HLA-BTTC28BioGRID, IntAct26186194 28514442 details
HLA-BWDFY3BioGRID, IntAct26186194 28514442 details
HLA-BNCAPH2BioGRID, IntAct26186194 28514442 details
HLA-BHEATR6BioGRID, IntAct26186194 28514442 details
HLA-BFAM91A1BioGRID, IntAct26186194 28514442 details
HLA-BTUBA4ABioGRID, IntAct28514442 details
HLA-BATP12ABioGRID, IntAct26186194 28514442 details
HLA-BCLTCL1BioGRID, IntAct26186194 28514442 details
HLA-BHTTBioGRID, IntAct26186194 28514442 details
HLA-BHLA-EBioGRID, IntAct26186194 28514442 details
HLA-BLTN1BioGRID, IntAct26186194 28514442 details
HLA-BADAM21BioGRID, IntAct28514442 details
HLA-BSIAEBioGRID, IntAct26186194 28514442 details
HLA-BTCTN2BioGRID, IntAct28514442 details
HLA-BHLA-GBioGRID, IntAct28514442 details
HLA-BPLGRKTIntAct29568061 details
HLA-BSH2D3CBioGRID, IntAct31980649 details
HLA-BPAK1BioGRID, IntAct31980649 details
HLA-BPCK1BioGRID21726808 details
HLA-BNDUFA9BioGRID22939629 details
HLA-BMMS19BioGRID22678362 details
HLA-BADRB2BioGRID23798571 details
HLA-BTUBGCP2BioGRID26186194 details
HLA-BATP1A3BioGRID26186194 details
HLA-BHEATR1BioGRID26186194 details
HLA-BIPO13BioGRID26186194 details
HLA-BWDR11BioGRID26186194 details
HLA-BPDK1BioGRID26186194 28514442 details
HLA-BSLC39A3BioGRID26186194 details
HLA-BFCGRTBioGRID26186194 details
HLA-BUXS1BioGRID26186194 details
HLA-BNEK4BioGRID26186194 details
HLA-BFAF2BioGRID26389662 details
HLA-BEGFRBioGRID28065597 details
HLA-BPTPROBioGRID27432908 details
HLA-BEGLN3BioGRID26972000 details
HLA-BRNF4BioGRID29180619 details
HLA-BCGASBioGRID30471916 details
HLA-BPTRH2BioGRID29568061 details
HLA-BCTDP1BioGRID31240132 details
HLA-BCYB5R3BioGRID31536960 details
HLA-BCA9BioGRID28692057 details
HLA-BCHMP4CBioGRID31586073 details
HLA-BKIF23BioGRID31586073 details
HLA-BPMAIP1BioGRID32913203 details
HLA-BPRKNBioGRID32929329 details
HLA-BDDX58BioGRID32513696 details