Entity Details

Primary name KIF14_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15058
EntryNameKIF14_HUMAN
FullNameKinesin-like protein KIF14
TaxID9606
Evidenceevidence at protein level
Length1648
SequenceStatuscomplete
DateCreated2002-09-19
DateModified2021-06-02

Ontological Relatives

GenesKIF14

GO terms

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GOName
GO:0001558 regulation of cell growth
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0007018 microtubule-based movement
GO:0007080 mitotic metaphase plate congression
GO:0008017 microtubule binding
GO:0008284 positive regulation of cell population proliferation
GO:0008574 plus-end-directed microtubule motor activity
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0015631 tubulin binding
GO:0016020 membrane
GO:0016887 ATP hydrolysis activity
GO:0019901 protein kinase binding
GO:0021685 cerebellar granular layer structural organization
GO:0021693 cerebellar Purkinje cell layer structural organization
GO:0021695 cerebellar cortex development
GO:0021766 hippocampus development
GO:0021772 olfactory bulb development
GO:0021846 cell proliferation in forebrain
GO:0021987 cerebral cortex development
GO:0030155 regulation of cell adhesion
GO:0030165 PDZ domain binding
GO:0030334 regulation of cell migration
GO:0030496 midbody
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031641 regulation of myelination
GO:0032147 activation of protein kinase activity
GO:0032467 positive regulation of cytokinesis
GO:0032487 regulation of Rap protein signal transduction
GO:0033624 negative regulation of integrin activation
GO:0034446 substrate adhesion-dependent cell spreading
GO:0043066 negative regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045184 establishment of protein localization
GO:0051233 spindle midzone
GO:0051301 cell division
GO:0090543 Flemming body
GO:1903429 regulation of cell maturation
GO:2000045 regulation of G1/S transition of mitotic cell cycle

Subcellular Location

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Subcellular Location
Cytoplasm
Midbody
Nucleus

Domains

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DomainNameCategoryType
IPR000253 Forkhead-associated (FHA) domainDomainDomain
IPR001752 Kinesin motor domainDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR019821 Kinesin motor domain, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR027640 Kinesin-like proteinFamilyFamily
IPR032405 Kinesin-associatedDomainDomain
IPR036961 Kinesin motor domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616258 OMIMMeckel syndrome 12 (MKS12)A form of Meckel syndrome, a disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly. The disease is caused by variants affecting the gene represented in this entry.
617914 OMIMMicrocephaly 20, primary, autosomal recessive (MCPH20)A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH20 features include mild to moderate intellectual disability, autistic features, poor speech. Disease severity is highly variable. The disease is caused by variants affecting the gene represented in this entry. The disease-causing variant NM_014875.2:c.263T>A, which produces a premature truncation of the protein at Leu-88 (p.Leu88Ter), may also partly result in the deletion of 372 bp of exon 2 of KIF14 by activation of a cryptic splice site. This in-frame deletion predicts a protein that lacks 124 aa (p.Gly58-Leu181del). The disease-causing mutation NM_014875.2:c.3662G>T, resulting in the missence variant p.Gly1221Val, may also induce the skipping of exon 24, resulting in a protein that misses 76 aa (p.Gly1221_ Lys1296delinsVal).