Entity Details

Primary name ERBB4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15303
EntryNameERBB4_HUMAN
FullNameReceptor tyrosine-protein kinase erbB-4
TaxID9606
Evidenceevidence at protein level
Length1308
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesERBB4

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000976 transcription cis-regulatory region binding
GO:0001755 neural crest cell migration
GO:0001934 positive regulation of protein phosphorylation
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005154 epidermal growth factor receptor binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007416 synapse assembly
GO:0007507 heart development
GO:0007595 lactation
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009880 embryonic pattern specification
GO:0009925 basal plasma membrane
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016323 basolateral plasma membrane
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021551 central nervous system morphogenesis
GO:0021889 olfactory bulb interneuron differentiation
GO:0030334 regulation of cell migration
GO:0033674 positive regulation of kinase activity
GO:0038128 ERBB2 signaling pathway
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0045165 cell fate commitment
GO:0045211 postsynaptic membrane
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0046777 protein autophosphorylation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060644 mammary gland epithelial cell differentiation
GO:0060749 mammary gland alveolus development
GO:0061026 cardiac muscle tissue regeneration
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0099056 integral component of presynaptic membrane
GO:0099061 integral component of postsynaptic density membrane
GO:2000010 positive regulation of protein localization to cell surface
GO:2000145 regulation of cell motility
GO:2001223 negative regulation of neuron migration

Subcellular Location

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Subcellular Location
Cell membrane
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000494 Receptor L-domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR006211 Furin-like cysteine-rich domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR032778 Growth factor receptor domain 4DomainDomain
IPR036941 Receptor L-domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB08916 AfatinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12267 BrigatinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule

Interactions

177 interactions

InteractorPartnerSourcesPublicationsLink
ERBB4_HUMANDLG4_HUMANBioGRID, HPRD, IntAct, MINT10725395 10839362 12716924 16767099 17018285 details
ERBB4_HUMANSNTB2_HUMANBioGRID, HPRD, MINT10725395 details
ERBB4_HUMANDLG2_HUMANBioGRID, HPRD, MINT10725395 details
ERBB4_HUMANDLG3_HUMANBioGRID, HPRD, MINT10725395 12175853 details
ERBB4_HUMANGRB2_HUMANBioGRID, HPRD, IntAct, MINT16729043 22973453 24658140 25140053 details
ERBB4_HUMANSHC1_HUMANBioGRID, HPRD, IntAct, MINT16273093 16729043 22973453 24658140 9019162 details
ERBB4_HUMANNCK2_HUMANBioGRID, MINT16729043 22973453 details
ERBB4_HUMANPTN11_HUMANBioGRID, MINT16729043 22973453 28065597 details
ERBB4_HUMANP85B_HUMANBioGRID, HPRD, MINT16729043 22973453 details
ERBB4_HUMANABL2_HUMANBioGRID, MINT16273093 22973453 details
ERBB4_HUMANABL1_HUMANBioGRID, MINT16273093 22973453 details
ERBB4_HUMANKSYK_HUMANBioGRID, MINT16273093 22973453 details
ERBB4_HUMANRASA1_HUMANBioGRID, MINT16273093 22973453 details
ERBB4_HUMANANS1B_HUMANBioGRID, MINT16273093 details
ERBB4_HUMANANS1A_HUMANBioGRID, MINT16273093 details
ERBB4_HUMANEGFR_HUMANBioGRID, HPRD, IntAct10572067 16061658 23153581 25140053 25315821 details
ERBB4_HUMANERBB3_HUMANBioGRID, HPRD, IntAct10572067 20227043 25315821 7689552 details
ERBB4_HUMANERBB2_HUMANBioGRID, DIP, HPRD, IntAct10572067 10839362 16767099 21203579 24557338 25315821 30898150 8816440 details
ERBB4_HUMANWWOX_HUMANBioGRID, IntAct16061658 19047365 20943952 22584572 24550385 details
ERBB4_HUMANHDAC6_HUMANBioGRID, IntAct20029029 31980649 details
ERBB4_HUMANTROP_HUMANBioGRID, UniProt17360433 21191175 details
ERBB4_HUMANHS90A_HUMANBioGRID, IntAct22939624 24658140 details
ERBB4_HUMANG3P_HUMANIntAct24658140 details
ERBB4_HUMANCOF1_HUMANBioGRID, IntAct24658140 31980649 details
ERBB4_HUMANYAP1_HUMANBioGRID, HPRD, MINT12807903 15023535 16061658 19047365 25283809 details
ERBB4_HUMANDLG1_HUMANBioGRID, HPRD, MINT12175853 24550280 details
ERBB4_HUMANBYST_HUMANBioGRID, DIP17360433 details
ERBB4_HUMANERBB4_HUMANBioGRID, DIP, HPRD10572067 16170367 18334220 20943952 25315821 8816440 details
ERBB4_HUMANITCH_HUMANBioGRID, DIP17463226 18334649 details
ERBB4_HUMANPTPRH_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANPTPRT_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANDUS14_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANDUS10_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANMPIP3_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANDUS18_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANDUS16_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANPTN12_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANDUS21_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANDUS6_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANILKAP_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANMTMR2_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANMTMR6_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANMTMR9_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANPPM1A_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANPPM1B_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANPPM1F_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANPTPC1_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANDUS19_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANPTPRR_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANSTYX_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANTAB1_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANPTN6_HUMANBioGRID, MINT22973453 28065597 details
ERBB4_HUMANPTN7_HUMANBioGRID, MINT28065597 details
ERBB4_HUMANS10A4_HUMANUniProt30083275 details
ERBB4_HUMANZN532_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANTHIO_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANTM14A_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANTM134_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANSYNEM_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANAP180_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANSELK_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANS10AA_HUMANIntAct31980649 details
ERBB4_HUMANRTN4_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANTMG4_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANPRDX5_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANPIN4_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANLRRC7_HUMANIntAct31980649 details
ERBB4_HUMANI2BP2_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANGBRL2_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANFKB1A_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANTV23B_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANTMA7_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANSIM20_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANTM230_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANERG28_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANF241B_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANALDOA_HUMANBioGRID, IntAct31980649 details
ERBB4_HUMANLRIG1_HUMANBioGRID, IntAct15282549 15345710 20126551 details
ERBB4_HUMANNRG1_HUMANBioGRID, HPRD, IntAct10537356 28988771 7721889 8062828 9168115 9565587 details
ERBB4_HUMANGRB7_HUMANBioGRID, IntAct22973453 29290818 details
ERBB4_HUMANCRK_HUMANBioGRID, HPRD16729043 22973453 details
ERBB4_HUMANNCK1_HUMANBioGRID16729043 22973453 details
ERBB4_HUMANRNF41_HUMANBioGRID, HPRD11867753 27648936 details
ERBB4_HUMANNRG2_HUMANBioGRID, HPRD15358134 9168114 9168115 details
ERBB4_HUMANWWP1_HUMANBioGRID19047365 19561640 details
ERBB4_HUMANNEDD4_HUMANBioGRID19193720 details
ERBB4_HUMANTAB2_HUMANBioGRID17018285 details
ERBB4_HUMANAP2C_HUMANBioGRID20943952 details
ERBB4_HUMANPTN20_HUMANBioGRID28065597 details
ERBB4_HUMANPTN21_HUMANBioGRID25681686 details
ERBB4_HUMANFYN_HUMANBioGRID17460065 details
ERBB4_HUMANNTRK2_HUMANBioGRID25052836 details
ERBB4_HUMANMUC4_HUMANBioGRID25315821 details
ERBB4_HUMANLRIG3_HUMANBioGRID20126551 details
ERBB4_HUMANS10AB_HUMANBioGRID31980649 details
ERBB4_HUMANBCAR3_HUMANBioGRID22973453 details
ERBB4_HUMANBLK_HUMANBioGRID22973453 details
ERBB4_HUMANFES_HUMANBioGRID22973453 details
ERBB4_HUMANFGR_HUMANBioGRID22973453 details
ERBB4_HUMANGRAP2_HUMANBioGRID22973453 details
ERBB4_HUMANGRB10_HUMANBioGRID22973453 details
ERBB4_HUMANHCK_HUMANBioGRID22973453 details
ERBB4_HUMANHSH2D_HUMANBioGRID22973453 details
ERBB4_HUMANSHIP2_HUMANBioGRID22973453 details
ERBB4_HUMANITK_HUMANBioGRID22973453 details
ERBB4_HUMANLCK_HUMANBioGRID22973453 details
ERBB4_HUMANLCP2_HUMANBioGRID22973453 details
ERBB4_HUMANLYN_HUMANBioGRID22973453 details
ERBB4_HUMANMATK_HUMANBioGRID22973453 details
ERBB4_HUMANP85A_HUMANBioGRID22973453 details
ERBB4_HUMANP55G_HUMANBioGRID22973453 details
ERBB4_HUMANPLCG1_HUMANBioGRID22973453 details
ERBB4_HUMANPLCG2_HUMANBioGRID22973453 details
ERBB4_HUMANPTK6_HUMANBioGRID22973453 details
ERBB4_HUMANSH2B1_HUMANBioGRID22973453 details
ERBB4_HUMANSH2B2_HUMANBioGRID22973453 details
ERBB4_HUMANSH2B3_HUMANBioGRID22973453 details
ERBB4_HUMANSH21A_HUMANBioGRID22973453 details
ERBB4_HUMANSH21B_HUMANBioGRID22973453 details
ERBB4_HUMANSH22A_HUMANBioGRID22973453 details
ERBB4_HUMANSH2D3_HUMANBioGRID22973453 details
ERBB4_HUMAN3BP2_HUMANBioGRID22973453 details
ERBB4_HUMANSHB_HUMANBioGRID22973453 details
ERBB4_HUMANSHC2_HUMANBioGRID22973453 details
ERBB4_HUMANSHC3_HUMANBioGRID22973453 details
ERBB4_HUMANSHC4_HUMANBioGRID22973453 details
ERBB4_HUMANSHD_HUMANBioGRID22973453 details
ERBB4_HUMANSLAP1_HUMANBioGRID22973453 details
ERBB4_HUMANSLAP2_HUMANBioGRID22973453 details
ERBB4_HUMANSOCS1_HUMANBioGRID22973453 details
ERBB4_HUMANSOCS2_HUMANBioGRID22973453 details
ERBB4_HUMANSOCS3_HUMANBioGRID22973453 details
ERBB4_HUMANSOCS5_HUMANBioGRID22973453 details
ERBB4_HUMANSOCS6_HUMANBioGRID22973453 details
ERBB4_HUMANSRC_HUMANBioGRID22973453 details
ERBB4_HUMANSTAP1_HUMANBioGRID22973453 details
ERBB4_HUMANTEC_HUMANBioGRID22973453 details
ERBB4_HUMANTNS2_HUMANBioGRID22973453 details
ERBB4_HUMANTENS1_HUMANBioGRID22973453 details
ERBB4_HUMANTENS3_HUMANBioGRID22973453 details
ERBB4_HUMANTENS4_HUMANBioGRID22973453 details
ERBB4_HUMANTXK_HUMANBioGRID22973453 details
ERBB4_HUMANVAV_HUMANBioGRID22973453 details
ERBB4_HUMANVAV2_HUMANBioGRID22973453 details
ERBB4_HUMANVAV3_HUMANBioGRID22973453 details
ERBB4_HUMANYES_HUMANBioGRID22973453 details
ERBB4_HUMANZAP70_HUMANBioGRID22973453 details
ERBB4_HUMANCRKL_HUMANMINT16729043 details
ERBB4_HUMANSTA5B_HUMANHPRD, MINT16729043 details
ERBB4_HUMANNMDZ1_HUMANIntAct16767099 details
ERBB4_HUMANHS90B_HUMANIntAct22939624 details
ERBB4_HUMANTROAP_HUMANDIP17360433 details
ERBB4_HUMANHBEGF_HUMANHPRD, UniProt9135143 details
ERBB4_HUMANSTA5A_HUMANBioGRID, HPRD15534001 16729043 22584572 details
ERBB4_HUMANCD44_HUMANBioGRID, HPRD11825873 details
ERBB4_HUMANMUC1_HUMANBioGRID, HPRD11278868 12939402 details
ERBB4_HUMANEREG_HUMANBioGRID, HPRD9419975 details
ERBB4_HUMANNCOR1_HUMANBioGRID17018285 details
ERBB4_HUMANPIAS3_HUMANBioGRID22584572 details
ERBB4_HUMANPIAS4_HUMANBioGRID22584572 details
ERBB4_HUMANTIF1B_HUMANBioGRID20858735 details
ERBB4_HUMANMDM2_HUMANBioGRID20858735 details
ERBB4_HUMANP53_HUMANBioGRID20858735 details
ERBB4_HUMANUBP8_HUMANBioGRID23153581 details
ERBB4_HUMANCBL_HUMANBioGRID25140053 details
ERBB4_HUMANAP2A_HUMANBioGRID20943952 details
ERBB4_HUMANESR1_HUMANBioGRID19439407 details
ERBB4_HUMANVANG1_HUMANBioGRID27648936 details
ERBB4_HUMANXPO1_HUMANBioGRID28974580 details
ERBB4_HUMANMAGI2_HUMANBioGRID17579610 details
ERBB4_HUMANKALRN_HUMANBioGRID21483438 details
ERBB4_HUMANBTC_HUMANHPRD11254912 details
ERBB4_HUMANADA17_HUMANHPRD15534001 details
ERBB4_HUMANNRG4_HUMANHPRD10348342 details
ERBB4_HUMANNRG3_HUMANHPRD9275162 details
ERBB4_HUMANTGFA_HUMANHPRD10918572 details
ERBB4_HUMANCCN2_HUMANHPRD12297288 details