Entity Details

Primary name IL1B
Entity type gene
Source Source Link

Details

PrimaryID3553
RefseqGeneNG_008851
SymbolIL1B
Nameinterleukin 1 beta
Chromosome2
Location2q14.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-27
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsIL1B_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0001660 fever generation
GO:0001934 positive regulation of protein phosphorylation
GO:0002711 positive regulation of T cell mediated immunity
GO:0005125 cytokine activity
GO:0005149 interleukin-1 receptor binding
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007566 embryo implantation
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0010573 vascular endothelial growth factor production
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010829 negative regulation of glucose transmembrane transport
GO:0014805 smooth muscle adaptation
GO:0019221 cytokine-mediated signaling pathway
GO:0019904 protein domain specific binding
GO:0030213 hyaluronan biosynthetic process
GO:0030335 positive regulation of cell migration
GO:0030730 sequestering of triglyceride
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0031622 positive regulation of fever generation
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032308 positive regulation of prostaglandin secretion
GO:0032496 response to lipopolysaccharide
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032743 positive regulation of interleukin-2 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0033092 positive regulation of immature T cell proliferation in thymus
GO:0033129 positive regulation of histone phosphorylation
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0035066 positive regulation of histone acetylation
GO:0035505 positive regulation of myosin light chain kinase activity
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0035690 cellular response to drug
GO:0042102 positive regulation of T cell proliferation
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043407 negative regulation of MAP kinase activity
GO:0043491 protein kinase B signaling
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0045833 negative regulation of lipid metabolic process
GO:0045840 positive regulation of mitotic nuclear division
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045917 positive regulation of complement activation
GO:0046330 positive regulation of JNK cascade
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046827 positive regulation of protein export from nucleus
GO:0050729 positive regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
GO:0050767 regulation of neurogenesis
GO:0050768 negative regulation of neurogenesis
GO:0050796 regulation of insulin secretion
GO:0050805 negative regulation of synaptic transmission
GO:0050995 negative regulation of lipid catabolic process
GO:0050996 positive regulation of lipid catabolic process
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051781 positive regulation of cell division
GO:0060252 positive regulation of glial cell proliferation
GO:0060355 positive regulation of cell adhesion molecule production
GO:0060559 positive regulation of calcidiol 1-monooxygenase activity
GO:0070164 negative regulation of adiponectin secretion
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070487 monocyte aggregation
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071310 cellular response to organic substance
GO:0071407 cellular response to organic cyclic compound
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:0150078 positive regulation of neuroinflammatory response
GO:1900745 positive regulation of p38MAPK cascade
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902680 positive regulation of RNA biosynthetic process
GO:1903140 regulation of establishment of endothelial barrier
GO:1903597 negative regulation of gap junction assembly
GO:2000556 positive regulation of T-helper 1 cell cytokine production
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Diseases

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Interactions

55 interactions

InteractorPartnerSourcesPublicationsLink
IL1BIL1R1BioGRID, HPRD, IntAct7878046 9062193 details
IL1BCASP1BioGRID, DIP, HPRD1919001 19439663 28147281 32122970 7642516 7797510 details
IL1BEGR1BioGRID22455954 details
IL1BSP1BioGRID22455954 details
IL1BAPPBioGRID21832049 details
IL1BCMA1BioGRID1919436 details
IL1BFYNBioGRID9230816 details
IL1BLYNBioGRID9230816 details
IL1BNEDD4BioGRID32597834 details
IL1BIL1RAPDIP, HPRD, InnateDB16306937 20802483 22426547 9820540 details
IL1BA2MBioGRID, HPRD, IntAct2466831 25241761 9714181 details
IL1BIKBKGInnateDB23104095 details
IL1BPTPN1BioGRID23439647 details
IL1BIRAK1BioGRID10823834 details
IL1BGSDMDBioGRID32597834 details
IL1BCASP8BioGRID32597834 details
IL1BCDC37BioGRID32597834 details
IL1BHSP90AA1BioGRID32597834 details
IL1BNLRP3BioGRID32597834 details
IL1BMMP2HPRD8663297 details
IL1BADRB2HPRD11238007 details
IL1BCASP4HPRD1919001 7797510 details
IL1BIL1BHPRD2946959 details
IL1BIL1R2HPRD7878046 details
IL1BPRTN3HPRD10339575 details
IL1BMYCIntAct21150319 details
IL1BPKMIntAct24606918 details
IL1BSTING1IntAct29251827 details
IL1BPDCD6IPBioGRID32597834 details
IL1BATG3BioGRID32597834 details
IL1BATG7BioGRID32597834 details
IL1BCHMP4BBioGRID32597834 details
IL1BIL18BioGRID32597834 details
IL1BRAB5ABioGRID32597834 details
IL1BSEC22BBioGRID32597834 details
IL1BSTXBP2BioGRID32597834 details
IL1BSTXBP3BioGRID32597834 details
IL1BUBE2D3BioGRID32597834 details
IL1BVPS28BioGRID32597834 details
IL1BVPS4BBioGRID32597834 details
IL1BYWHAEBioGRID32597834 details
IL1BYWHAZBioGRID32597834 details
IL1BZNF710IntAct33179750 details
IL1BRXRGIntAct33179750 details
IL1BNR2F2IntAct33179750 details
IL1BNR1I2IntAct33179750 details
IL1BELAVL1BioGRID19322201 details
IL1BZC3H12ABioGRID19909337 details
IL1BEP300BioGRID31953354 details
IL1BCDK9BioGRID31953354 details
IL1BNSMFBioGRID31953354 details
IL1BKAT5BioGRID31953354 details
IL1BRBFOX1BioGRID31953354 details
IL1BSUZ12BioGRID31953354 details
IL1BEZH2BioGRID31953354 details