Entity Details

Primary name ITGB3
Entity type gene
Source Source Link

Details

PrimaryID3690
RefseqGeneNG_008332
SymbolITGB3
Nameintegrin subunit beta 3
Chromosome17
Location17q21.32
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-12

Ontological Relatives

UniProt IDsITB3_HUMAN

GO terms

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GOName
GO:0001618 virus receptor activity
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001968 fibronectin binding
GO:0002020 protease binding
GO:0002576 platelet degranulation
GO:0003756 protein disulfide isomerase activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005178 integrin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007596 blood coagulation
GO:0008305 integrin complex
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010888 negative regulation of lipid storage
GO:0014909 smooth muscle cell migration
GO:0015026 coreceptor activity
GO:0016477 cell migration
GO:0019899 enzyme binding
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031092 platelet alpha granule membrane
GO:0031258 lamellipodium membrane
GO:0031527 filopodium membrane
GO:0031528 microvillus membrane
GO:0031589 cell-substrate adhesion
GO:0032147 activation of protein kinase activity
GO:0032369 negative regulation of lipid transport
GO:0032587 ruffle membrane
GO:0032880 regulation of protein localization
GO:0032991 protein-containing complex
GO:0033627 cell adhesion mediated by integrin
GO:0034113 heterotypic cell-cell adhesion
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034683 integrin alphav-beta3 complex
GO:0035295 tube development
GO:0035866 alphav-beta3 integrin-PKCalpha complex
GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0035868 alphav-beta3 integrin-HMGB1 complex
GO:0038027 apolipoprotein A-I-mediated signaling pathway
GO:0042060 wound healing
GO:0042470 melanosome
GO:0042802 identical protein binding
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0043235 receptor complex
GO:0043277 apoptotic cell clearance
GO:0045124 regulation of bone resorption
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0046718 viral entry into host cell
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048333 mesodermal cell differentiation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050748 negative regulation of lipoprotein metabolic process
GO:0050839 cell adhesion molecule binding
GO:0050840 extracellular matrix binding
GO:0050900 leukocyte migration
GO:0050919 negative chemotaxis
GO:0051611 regulation of serotonin uptake
GO:0060055 angiogenesis involved in wound healing
GO:0070062 extracellular exosome
GO:0070527 platelet aggregation
GO:0071062 alphav-beta3 integrin-vitronectin complex
GO:0098978 glutamatergic synapse
GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization
GO:1905598 negative regulation of low-density lipoprotein receptor activity

Diseases

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Interactions

75 interactions

InteractorPartnerSourcesPublicationsLink
ITGB3ITGAVBioGRID, DIP, HPRD, I2D, IntAct, MINT10891446 11546839 11884718 15299032 16099422 1694173 20639902 22178926 24658351 25792870 9686320 details
ITGB3EPS8HPRD, MINT12606711 details
ITGB3RABGAP1MINT12606711 details
ITGB3ANKS1BMINT12606711 details
ITGB3GULP1MINT12606711 details
ITGB3RGS12MINT12606711 details
ITGB3MAPK8IP1MINT12606711 details
ITGB3TNS2HPRD, MINT12606711 details
ITGB3ITGB3DIP, HPRD, IntAct11606749 12606711 14681217 22178926 details
ITGB3ITGA2BBioGRID, DIP, HPRD, IntAct, MINT10358085 10891446 11412103 11606749 1429573 14681217 15067009 15219201 15379538 17032655 18791937 19279667 19805198 22178926 25849143 30804189 9351872 details
ITGB3TLN1BioGRID, HPRD, MINT10497223 11412103 11932255 12606711 16546176 19843520 details
ITGB3FN1BioGRID, DIP, HPRD, IntAct11478883 1694173 24658351 24789099 details
ITGB3LYNmbinfo14593208 details
ITGB3FGGBioGRID, HPRD, IntAct10747940 16877710 24789099 25398877 details
ITGB3CX3CL1IntAct23125415 24789099 details
ITGB3FLNABioGRID, DIP11807098 25849143 details
ITGB3PTK2BioGRID11927607 19889638 9169439 details
ITGB3FLNBBioGRID11807098 details
ITGB3ITGB3BPBioGRID, HPRD11864709 7593198 details
ITGB3THBS1BioGRID, HPRD14963009 2478219 details
ITGB3PTK2BBioGRID, HPRD11683411 details
ITGB3PXNBioGRID11683411 details
ITGB3ITGA5BioGRID, HPRD10358085 1694173 22470492 26344197 details
ITGB3P4HBBioGRID21670307 details
ITGB3PLA2G4ABioGRID18840708 details
ITGB3MAPK3BioGRID23640055 details
ITGB3SHC1BioGRID, HPRD10896934 10964917 19889638 details
ITGB3PLA2G2ABioGRID18635536 details
ITGB3DOK1BioGRID, HPRD12606711 19843520 details
ITGB3FGABioGRID, HPRD11460491 9058485 details
ITGB3SRCBioGRID, HPRD10896934 11723131 details
ITGB3AKT1BioGRID, HPRD10896934 details
ITGB3PDK1BioGRID10896934 details
ITGB3CDK1BioGRID10896934 details
ITGB3FGFR1BioGRID27371729 details
ITGB3APPBioGRID27221710 details
ITGB3HRASBioGRID30655611 details
ITGB3GRIA2BioGRID22232691 details
ITGB3PTPN1MINT16115959 details
ITGB3PTPN11MINT12791772 details
ITGB3PTPRZ1BioGRID, I2D19141530 20639902 details
ITGB3ILKBioGRID, HPRD12372433 details
ITGB3PECAM1BioGRID, HPRD10982404 details
ITGB3PDGFRBBioGRID, HPRD10964931 details
ITGB3PDGFRABioGRID, HPRD11953315 details
ITGB3CD36BioGRID, HPRD11238109 details
ITGB3SYKBioGRID11042121 details
ITGB3EPHA2BioGRID23874206 details
ITGB3VIMBioGRID18840708 details
ITGB3PRKCBBioGRID18840708 details
ITGB3KDRBioGRID, HPRD10022831 25644401 details
ITGB3PAK4BioGRID23254288 details
ITGB3MMP2BioGRID23254288 details
ITGB3ITGA4BioGRID25792870 details
ITGB3ITGB1BioGRID25792870 details
ITGB3CIB1BioGRID24163826 details
ITGB3FERMT3BioGRID25609252 details
ITGB3PTNBioGRID19141530 details
ITGB3TGM2HPRD10684262 details
ITGB3P2RY2HPRD11331301 details
ITGB3DAB2HPRD12606711 details
ITGB3DAB1HPRD12606711 details
ITGB3NUMBHPRD12606711 details
ITGB3PDPK1HPRD10896934 details
ITGB3ANGPTL3HPRD11877390 details
ITGB3VTNHPRD16195248 details
ITGB3CAPN1HPRD7592818 details
ITGB3THY1HPRD15897908 details
ITGB3COL1A2HPRD1693626 details
ITGB3NID1HPRD8831898 9686320 details
ITGB3FBLN2HPRD10848816 details
ITGB3ADAM15IntAct24789099 details
ITGB3CX3CR1IntAct23125415 details
ITGB3ZFP36L2BioGRID29449217 details
ITGB3DDX58BioGRID32513696 details