Entity Details

Primary name MET
Entity type gene
Source Source Link

Details

PrimaryID4233
RefseqGeneNG_008996
SymbolMET
NameMET proto-oncogene, receptor tyrosine kinase
Chromosome7
Location7q31.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-20
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsMET_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001886 endothelial cell morphogenesis
GO:0001889 liver development
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005008 hepatocyte growth factor-activated receptor activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006909 phagocytosis
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0010507 negative regulation of autophagy
GO:0016021 integral component of membrane
GO:0016477 cell migration
GO:0017154 semaphorin receptor activity
GO:0019903 protein phosphatase binding
GO:0030182 neuron differentiation
GO:0031016 pancreas development
GO:0031116 positive regulation of microtubule polymerization
GO:0033674 positive regulation of kinase activity
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035635 entry of bacterium into host cell
GO:0042802 identical protein binding
GO:0043235 receptor complex
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050918 positive chemotaxis
GO:0051497 negative regulation of stress fiber assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0061436 establishment of skin barrier
GO:0070495 negative regulation of thrombin-activated receptor signaling pathway
GO:0071526 semaphorin-plexin signaling pathway
GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death
GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity
GO:2001028 positive regulation of endothelial cell chemotaxis

Diseases

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Interactions

161 interactions

InteractorPartnerSourcesPublicationsLink
METCBLBioGRID, HPRD, IntAct, MINT11894096 15123609 16397241 18273061 19433454 19450681 21163258 21222362 25241761 details
METRANBP9BioGRID, HPRD, MINT12147692 details
METPLXNB1HPRD, IntAct, MINT, Molecular Connections12198496 15184888 22404908 details
METHGFBioGRID, DIP, HPRD, IntAct15167892 16537482 1655405 17804794 17981115 1846706 18495663 18593464 19433454 20624990 22897854 28205554 8380735 details
METPTPN1IntAct, MINT16537444 18579758 22789536 details
METPTPN11BioGRID, HPRD, IntAct, MINT18579758 24728074 8662733 details
METPTPRCIntAct19167335 details
METPTPRKIntAct19167335 details
METPTPRGIntAct19167335 details
METPTPRJHPRD, IntAct, MINT12370829 12475979 19167335 details
METPTPROBioGRID, IntAct19167335 28330616 details
METPTPN3IntAct19167335 details
METPTPN12IntAct19167335 details
METEGFRBioGRID, DIP, HPRD, IntAct, Molecular Connections10722725 20624308 21918175 23866081 24189400 24362532 26551075 details
METSRCBioGRID, HPRD, IntAct, Molecular Connections20624308 24034250 24728074 9837958 details
METPASKMINT21418524 details
METDNAJA3HPRD, I2D15546961 21242965 details
METPTPRBHPRD, MINT16101282 details
METCD44BioGRID, IntAct22897854 28205554 details
METRASA1BioGRID, IntAct24728074 details
METPIK3R1BioGRID, HPRD, IntAct24728074 7513258 details
METSOCS6BioGRID, IntAct24728074 details
METSTAP1BioGRID, IntAct24728074 details
METPIK3R3BioGRID, IntAct24728074 details
METLCKBioGRID, IntAct24728074 details
METSHC4BioGRID, IntAct24728074 details
METSH2D1BBioGRID, IntAct24728074 details
METSHDBioGRID, IntAct24728074 details
METSHC2BioGRID, IntAct24728074 details
METSH2D3CBioGRID, IntAct24728074 details
METPIK3R2BioGRID, IntAct24728074 details
METSYKBioGRID, IntAct24728074 details
METTNS3BioGRID, IntAct24728074 details
METSHC1BioGRID, HPRD, IntAct24728074 7731718 9660480 details
METYES1BioGRID, IntAct24728074 details
METSHBBioGRID, IntAct24728074 details
METSH2D2ABioGRID, IntAct24728074 details
METSLA2BioGRID, IntAct24728074 details
METVAV3BioGRID, IntAct24728074 details
METSH2D1ABioGRID, IntAct24728074 details
METPLCG1BioGRID, HPRD, IntAct24728074 7513258 8662733 details
METNCK2BioGRID, IntAct24728074 details
METNCK1BioGRID, IntAct24728074 details
METSH3BP2BioGRID, IntAct24728074 details
METSOCS5BioGRID, IntAct24728074 details
METSOCS3BioGRID, IntAct24728074 details
METLYNBioGRID, IntAct24728074 34079125 details
METTECBioGRID, IntAct24728074 details
METBLKBioGRID, IntAct24728074 details
METZAP70BioGRID, IntAct24728074 details
METTNS2BioGRID, IntAct24728074 details
METPLCG2BioGRID, IntAct24728074 details
METTNS1BioGRID, IntAct24728074 details
METFGRBioGRID, IntAct24728074 details
METITKBioGRID, IntAct24728074 details
METSHC3BioGRID, IntAct24728074 details
METHCKBioGRID, IntAct24728074 details
METPTK6BioGRID, IntAct24728074 details
METTXKBioGRID, IntAct24728074 details
METSOCS2BioGRID, IntAct24728074 details
METGRB7BioGRID, IntAct24728074 details
METABL2BioGRID, IntAct24728074 details
METMATKBioGRID, IntAct24728074 details
METSOCS1BioGRID, IntAct24728074 25728680 details
METGRB14BioGRID, IntAct24728074 details
METHSH2DBioGRID, IntAct24728074 details
METSH2B1BioGRID, IntAct24728074 details
METBTKBioGRID, IntAct24728074 details
METINPPL1BioGRID, HPRD, IntAct15735664 19713535 24728074 details
METVAV2BioGRID, IntAct24728074 details
METFESBioGRID, IntAct24728074 details
METTNS4BioGRID, IntAct24728074 details
METCRKBioGRID, IntAct24728074 24828152 details
METSH2B3BioGRID, IntAct24728074 details
METBCAR3BioGRID, IntAct24728074 details
METSH2B2BioGRID, IntAct24728074 details
METSCRIBMINT24550280 details
METMETBioGRID, DIP, HPRD16537482 1655405 1655790 17192257 20624990 23794705 26285778 details
METMNDAIntAct32814053 details
METGRB2BioGRID, HPRD, IntAct11063574 11439336 15546961 19433454 21222362 7511210 8662889 9660480 details
METGLMNBioGRID, HPRD11571281 details
METRANBP10BioGRID, HPRD14684163 details
METDCNBioGRID19433454 details
METITGB1BioGRID28973887 details
METERBB2BioGRID30898150 details
METGLIS2BioGRID28205554 details
METMAP2K5BioGRID28205554 details
METCCND2BioGRID28205554 details
METEPHA2BioGRID28205554 details
METFGFR4BioGRID28205554 details
METSTK11BioGRID28205554 details
METFZR1BioGRID28205554 details
METKDELR2BioGRID28205554 details
METMAP2K3BioGRID28205554 details
METCDK4BioGRID28205554 details
METCDK6BioGRID28205554 details
METCDKN2BBioGRID28205554 details
METLATS2BioGRID28205554 details
METTERTBioGRID28205554 details
METMYCBioGRID28205554 details
METNF2BioGRID28205554 details
METRAF1BioGRID28205554 details
METRASSF1BioGRID28205554 details
METTP53BioGRID28205554 details
METSNAPINHPRD15546961 details
METPCBD2HPRD15546961 details
METVAV1HPRD15546961 details
METSNX2HPRD15546961 details
METDAPK3HPRD15546961 details
METSMC1AHPRD15546961 details
METINPP5DHPRD15735664 details
METMUC20HPRD15314156 details
METGAB1BioGRID, HPRD, MINT10734310 10871282 10913131 10995442 9242692 details
METYWHAZIntAct17353931 details
METPLXNB2IntAct15184888 details
METPLXNB3IntAct15184888 details
METKDRIntAct22789536 details
METCASP3BioGRID, HPRD, IntAct15542841 25241761 details
METMUC1Molecular Connections22962849 details
METLAPTM4BIntAct25594178 details
METERBB3BioGRID, DIP21918175 25326665 details
METLRIG1BioGRID, IntAct17178829 24828152 details
METCDH1BioGRID11254878 details
METCTNNB1BioGRID, HPRD11254878 11929826 details
METSH3KBP1BioGRID11894096 details
METSOS1BioGRID9660480 details
METSTAT3BioGRID, HPRD9440692 details
METGAB2BioGRID10871282 details
METSPSB1BioGRID, HPRD15713673 details
METSPSB2BioGRID15713673 details
METSPSB3BioGRID15713673 details
METSPSB4BioGRID15713673 details
METCBLCBioGRID22888118 details
METSTUB1BioGRID21325980 details
METHSPA4BioGRID21325980 details
METHSP90AA1BioGRID21325980 26517842 details
METGGA3BioGRID21664574 details
METHGSBioGRID, HPRD24828152 8380735 details
METHSP90AB1BioGRID26517842 details
METSFNBioGRID29880877 details
METITGAVBioGRID28973887 details
METGSK3BBioGRID30711629 details
METCNR1HPRD11894096 details
METFASHPRD15911745 details
METITGB4HPRD11733063 14602071 details
METCTTNHPRD11439336 details
METBAG1HPRD8947043 details
METPKMIntAct24606918 details
METSCGB1D1BioGRID, IntAct28514442 details
METLGALS9BioGRID, IntAct26186194 28514442 details
METPCBP1BioGRID, IntAct26186194 28514442 details
METCEACAM21BioGRID, IntAct26186194 28514442 details
METLAMP1BioGRID, IntAct29568061 details
METGNG12BioGRID22939629 details
METFBXO6BioGRID22268729 32409323 details
METHRASBioGRID30639242 details
METDNAJC5BioGRID33957083 details
METC11orf52BioGRID34079125 details
METGJA1BioGRID34079125 details
METKRASBioGRID34079125 details
METVIRMABioGRID29507755 details