Entity Details

Primary name LAMA4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16363
EntryNameLAMA4_HUMAN
FullNameLaminin subunit alpha-4
TaxID9606
Evidenceevidence at protein level
Length1823
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesLAMA4

GO terms

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GOName
GO:0005102 signaling receptor binding
GO:0005201 extracellular matrix structural constituent
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0007155 cell adhesion
GO:0030155 regulation of cell adhesion
GO:0030198 extracellular matrix organization
GO:0030334 regulation of cell migration
GO:0045995 regulation of embryonic development
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0120163 negative regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR001791 Laminin G domainDomainDomain
IPR002049 Laminin EGF domainDomainDomain
IPR009254 Laminin alpha, domain IDomainDomain
IPR010307 Laminin domain IIDomainDomain
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615235 OMIMCardiomyopathy, dilated 1JJ (CMD1JJ)A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. The disease is caused by variants affecting the gene represented in this entry.